Skip to main content

Research Repository

Advanced Search

All Outputs (36)

Urine protein concentration estimation for biomarker discovery (2013)
Journal Article
Mistry, H. D., Bramham, K., Weston, A., Ward, M., Thompson, A., & Chappell, L. C. (2013). Urine protein concentration estimation for biomarker discovery. Pregnancy Hypertension, 3(4), https://doi.org/10.1016/j.preghy.2013.07.001

Recent advances have been made in the study of urinary proteomics as a diagnostic tool for renal disease and pre-eclampsia which requires accurate measurement of urinary protein. We compared different protein assays (Bicinchoninic acid (BCA), Lowry a... Read More about Urine protein concentration estimation for biomarker discovery.

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype (2013)
Journal Article
Hentchke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Kurlak, L., Williams, P. J., & Mistry, H. D. (2013). Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54, https://doi.org/10.1194/jlr.M036699

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-... Read More about Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype.

Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy (2013)
Journal Article
Kurlak, L., Mistry, H., Kaptein, E., Visser, T., & Broughton Pipkin, F. (2013). Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy. Placenta, 34(5), https://doi.org/10.1016/j.placenta.2013.02.009

Pre-eclampsia is associated with lower serum selenium concentrations and glutathione peroxidase expression/activity; total thyroid hormones are also lower. Objectives, study design and main outcome measures: We hypothesised that the placental seleno... Read More about Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.

The placental renin-angiotensin system and oxidative stress in pre-eclampsia (2012)
Journal Article
Mistry, H., Kurlak, L., & Broughton Pipkin, F. (2013). The placental renin-angiotensin system and oxidative stress in pre-eclampsia. Placenta, 34(2), https://doi.org/10.1016/j.placenta.2012.11.027

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-e... Read More about The placental renin-angiotensin system and oxidative stress in pre-eclampsia.

Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants (2012)
Journal Article
Mistry, H. D., Kurlak, L., Young, S. D., Briley, A., Broughton Pipkin, F., Baker, P., & Poston, L. (2014). Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants. Maternal and Child Nutrition, 10, https://doi.org/10.1111/j.1740-8709.2012.00430.x

Pregnancy during adolescence increases the risk of adverse pregnancy outcome, especially risk of small-for gestational-age (SGA) birth, which has been linked to micronutrient deficiencies. Likewise, smoking has been shown to be related with lower mic... Read More about Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants.

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia (2012)
Journal Article
Williams, P. J., Mistry, H. D., & Morgan, L. (2012). Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertension, 2(2), https://doi.org/10.1016/j.preghy.2011.12.001

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-?), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent tr... Read More about Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia.

Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia (2011)
Journal Article
Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011). Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia. Hypertension, 58, https://doi.org/10.1161/HYPERTENSIONAHA.111.173740

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascu... Read More about Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia.

The importance of antioxidant micronutrients and vitamins in pregnancy (2011)
Journal Article
Mistry, H. D., & Williams, P. J. (2011). The importance of antioxidant micronutrients and vitamins in pregnancy. Oxidative Medicine and Cellular Longevity, 2011, https://doi.org/10.1155/2011/841749

Pregnancy places increased demands on the mother to provide not only adequate nutrition to support her own health but also to enable the growth and development of the conceptus. A key role of a number of micronutrients and vitamins is their function... Read More about The importance of antioxidant micronutrients and vitamins in pregnancy.

Selenium in reproduction (2011)
Journal Article
Mistry, H. D., Broughton Pipkin, F., Redman, C. W., & Poston, L. (2012). Selenium in reproduction. American Journal of Obstetrics and Gynecology, 206(1), https://doi.org/10.1016/j.ajog.2011.07.034

Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now reco... Read More about Selenium in reproduction.

The role of oxidative stress and antioxidant supplementation in pregnancy disorders (2011)
Journal Article
Poston, L., Igosheva, N., Mistry, H. D., Seed, P. T., Shennan, A. H., Rana, S., …Chappell, L. C. (2011). The role of oxidative stress and antioxidant supplementation in pregnancy disorders. American Journal of Clinical Nutrition, 94(6Suppl), Article 1980S-1985S. https://doi.org/10.3945/ajcn.110.001156

Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an an... Read More about The role of oxidative stress and antioxidant supplementation in pregnancy disorders.

Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity (2011)
Journal Article
Mistry, H. D., Mather, J., Ramsay, M. M., Kurlak, L. O., Symonds, M. E., & Broughton Pipkin, F. (2011). Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity. Pregnancy Hypertension, 1(2), https://doi.org/10.1016/j.preghy.2011.01.006

Pre-eclampsia affects between 2-7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations. Objectives: Firstly, t... Read More about Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity.

Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human (2010)
Journal Article
Williams, P., Mistry, H., Innes, B., Bulmer, J., & Broughton Pipkin, F. (2010). Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.014

The placental renin-angiotensin system (RAS) is active from early pregnancy and may have a role in placentation. Angiotensin II (AngII) acts via binding to receptor types AT1R and AT2R. Recently smaller peptide members of the angiotensin family have... Read More about Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human.

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy (2010)
Journal Article
Mistry, H., Kurlak, L., Williams, P., Ramsay, M., Symonds, M., & Broughton Pipkin, F. (2010). Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.011

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenopr... Read More about Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.

The non-invasive biopsy: will urinary proteomics make the renal tissue biopsy redundant? (2009)
Journal Article
Bramham, K., Mistry, H., Poston, L., Chappell, L., & Thompson, A. (2009). The non-invasive biopsy: will urinary proteomics make the renal tissue biopsy redundant?. QJM: An International Journal of Medicine, 102(8), https://doi.org/10.1093/qjmed/hcp071

Proteomics is a rapidly advancing technique which gives a functional insight into gene expression in living organisms. Urine is an ideal medium for study as it is readily available, easily obtained and less complex than other bodily fluids. Consider... Read More about The non-invasive biopsy: will urinary proteomics make the renal tissue biopsy redundant?.

Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies (2008)
Journal Article
Mistry, H. D., Wilson, V., Ramsay, M. M., Symonds, M. E., & Broughton Pipkin, F. (2008). Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension, 52, https://doi.org/10.1161/HYPERTENSIONAHA.108.116103

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, act... Read More about Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies.