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All Outputs (100)

Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study (2020)
Journal Article
Young, B., Fogarty, A. W., Skelly, R., Shaw, D., Thurley, P., Sturrock, N., …Cranwell, J. (2020). Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study. Public Health, 185, 338-340. https://doi.org/10.1016/j.puhe.2020.06.023

© 2020 The Authors Objectives: There is a need to improve efficiency in healthcare delivery without compromising quality of care. One approach is the development and evaluation of behavioural strategies to reduce unnecessary use of common tests. Howe... Read More about Patients' attitudes towards cost feedback to doctors to prevent unnecessary testing: a qualitative focus group study.

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation (2020)
Journal Article
Kolmert, J., Gómez, C., Balgoma, D., Sjödin, M., Bood, J., Konradsen, J. R., …U-BIOPRED Study Group. (2021). Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation. American Journal of Respiratory and Critical Care Medicine, 203(1), 37–53. https://doi.org/10.1164/rccm.201909-1869oc

Rationale: New approaches are needed to guide personalized treatment of asthma. Objective: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PG), cysteinyl-leukotrienes (LT)... Read More about Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study (2020)
Journal Article
Young, B., Fogarty, A. W., Skelly, R., Shaw, D., Sturrock, N., Norwood, M., …Cranwell, J. (2020). Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study. BMC Medical Informatics and Decision Making, 20(1), 80. https://doi.org/10.1186/s12911-020-1087-2

BACKGROUND: Avoidable use of diagnostic tests can both harm patients and increase the cost of healthcare. Nudge-type educational interventions have potential to modify clinician behaviour while respecting clinical autonomy and responsibility, but the... Read More about Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England (2020)
Journal Article
Chalitsios, C. V., Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England. npj Primary Care Respiratory Medicine, 30(1), https://doi.org/10.1038/s41533-020-0162-6

© 2020, The Author(s). Exposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporo... Read More about A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England.

Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study (2019)
Journal Article
Young, B., Cranwell, J., Fogarty, A. W., Skelly, R., Sturrock, N., Norwood, M., …Thurley, P. (2019). Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study. BMC Health Services Research, 19, https://doi.org/10.1186/s12913-019-4712-y

Background: In the context of increasing availability of computed tomography (CT) scans, judicious use of ionising radiation is a priority to minimise the risk of future health problems. Hence, education of clinicians on the risks and benefits of CT... Read More about Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study.

Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study (2019)
Journal Article
Lewis, S., Young, B., Thurley, P., Shaw, D., Cranwell, J., Skelly, R., …Fogarty, A. W. (2019). Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study. Future Healthcare Journal, 6(3), 204-208. https://doi.org/10.7861/fhj.2019-0001

Background: Behavioural insights or ‘nudge’ theory suggests that non-directional interventions may be used to modify human behaviour. We have tested the hypothesis that the provision of the cost of common blood tests with their results may modify sub... Read More about Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study.

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation (2019)
Journal Article
Clifford, R. L., Patel, J., MacIsaac, J. L., McEwen, L. M., Johnson, S. R., Shaw, D., …Kobor, M. S. (2019). Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation. Scientific Reports, 9(1), 1-12. https://doi.org/10.1038/s41598-019-50873-y

The airway epithelium forms the interface between the inhaled environment and the lung. The airway epithelium is dysfunctional in asthma and epigenetic mechanisms are considered a contributory factor. We hypothesised that the DNA methylation profiles... Read More about Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Changes in Asthma Mortality in England and Wales since 2001 (2019)
Journal Article
Shaw, D. E., Gaynor, C. M., & Fogarty, A. (2019). Changes in Asthma Mortality in England and Wales since 2001. Thorax, 74(12), 1174-1175. https://doi.org/10.1136/thoraxjnl-2019-213350

The number of deaths from asthma in England and Wales has not changed significantly over the last decade. This lack of improvement has received attention from both national asthma guidelines and the media. We examined asthma death data from the Offic... Read More about Changes in Asthma Mortality in England and Wales since 2001.

Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study (2019)
Journal Article
Lewis, S., Shaw, D., Langley, T., Fogarty, A., Young, B., & Cranwell, O. (2019). Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study. Clinical Medicine, 19(4), 290-293. https://doi.org/10.7861/clinmedicine.19-4-290

Computerised tomography (CT) is readily available in developed countries. As one of the side-effects includes an increased risk of cancer, interventions that may encourage more judicious use of CT scans are important. Behavioural economics theory inc... Read More about Evaluation of a nudge intervention providing simple feedback to clinicians of the consequence of radiation exposure on demand for computerised tomography scans: a prospective, controlled study.

An interview analysis of coordination behaviours in out-of-hours secondary care (2019)
Journal Article
Martindale, S., Golightly, D., Pinchin, J., Shaw, D., Blakey, J., Perez, I., & Sharples, S. (2019). An interview analysis of coordination behaviours in out-of-hours secondary care. Applied Ergonomics, 81, Article 102861. https://doi.org/10.1016/j.apergo.2019.05.011

This paper seeks to elicit and structure the factors that shape the execution and, in particular, the coordination of work in Out of Hours care. Evenings and weekends in UK hospitals are managed by specific Out of Hours (OoH) care arrangements, and a... Read More about An interview analysis of coordination behaviours in out-of-hours secondary care.

IL-17–high asthma with features of a psoriasis immunophenotype (2019)
Journal Article
Östling, J., van Geest, M., Schofield, J. P., Jevnikar, Z., Wilson, S., Ward, J., …Praticò, G. (2019). IL-17–high asthma with features of a psoriasis immunophenotype. Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. https://doi.org/10.1016/j.jaci.2019.03.027

© 2019 American Academy of Allergy, Asthma & Immunology Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom furt... Read More about IL-17–high asthma with features of a psoriasis immunophenotype.

Stratification of asthma phenotypes by airway proteomic signatures (2019)
Journal Article
Schofield, J. P., Burg, D., Nicholas, B., Strazzeri, F., Brandsma, J., Staykova, D., …Nihlén, U. (2019). Stratification of asthma phenotypes by airway proteomic signatures. Journal of Allergy and Clinical Immunology, 144(1), 70-82. https://doi.org/10.1016/j.jaci.2019.03.013

© 2019 Background: Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better underst... Read More about Stratification of asthma phenotypes by airway proteomic signatures.

“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin (2019)
Journal Article
Pavlidis, S., Takahashi, K., Kwong, F. N. K., Xie, J., Hoda, U., Sun, K., …Chung, K. F. (2019). “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin. European Respiratory Journal, 53(1), Article 1800938. https://doi.org/10.1183/13993003.00938-2018

Copyright ©ERS 2019. Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate asthma into a T2-high phenotype. We examined whether currently available clinical biomarkers can predict AEC-defined T2-high phenotype withi... Read More about “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article
Shrine, N., Portelli, M. A., John, C., Soler Artigas, M., Bennett, N., Hall, R., …Sayers, I. (2019). Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 7(1), 20-34. https://doi.org/10.1016/S2213-2600%2818%2930389-8

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More about Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. (2018)
Journal Article
Brinkman, P., Wagener, A. H., Hekking, P., Bansal, A. T., Maitland-van der Zee, A., Wang, Y., …Study Group, U. (2019). Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. Journal of Allergy and Clinical Immunology, 143(5), 1811-1820. https://doi.org/10.1016/j.jaci.2018.10.058

Background: Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using “omics” technologies. Mo... Read More about Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma..

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort (2018)
Journal Article
Emma, R., Bansal, A. T., Kolmert, J., Wheelock, C. E., Dahlen, S., Loza, M. J., …U-BIOPRED Study Group. (2018). Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. PLoS ONE, 13(9), 1-16. https://doi.org/10.1371/journal.pone.0203874

Oxidative stress is believed to be a major driver of inflammation in smoking asthmatics. The U-BIOPRED project recruited a cohort of Severe Asthma smokers/ex-smokers (SAs/ex) and non-smokers (SAn) with extensive clinical and biomarker information ena... Read More about Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period (2018)
Journal Article
Forster, S., Housley, G., McKeever, T. M., & Shaw, D. E. (2018). Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period. BMJ Open, 8(7), Article e020269. https://doi.org/10.1136/bmjopen-2017-020269

Objective: Early Warning Scores (EWSs) are used to monitor patients for signs of imminent deterioration. Although used in respiratory disease, EWSs have not been well studied in this population, despite the underlying cardiopulmonary pathophysiology... Read More about Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period.

Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer (2018)
Journal Article
Jones, J. A., Catton, J., Howard, G., Leeder, P., Brewer, L., Hatton, J., & Shaw, D. E. (2018). Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer. BMJ Open Quality, 7(3), e000328. https://doi.org/10.1136/bmjoq-2018-000328

Background: Cancer survival in the UK has doubled in the last 40 years; however, 1-year and 5-year survival rates are still lower than other countries. One cause may be a delay between referral into secondary care and subsequent investigation. We set... Read More about Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer.