Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

Sagar, Devi Rani; Staniaszek, Lydia E.; Okine, Bright N.; Woodhams, Stephen; Norris, Leonie M.; Pearson, Richard G.; Garle, Michael J.; Alexander, Stephen P.H.; Bennett, Andrew J.; Barrett, David A.; Kendall, David A.; Scammell, Brigitte E.; Chapman, Victoria

doi:10.1002/art.27698

All Outputs (23)

Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis (2013)
Journal Article
Ashraf, S., Mapp, P. I., Chapman, V., Burston, J., Bennett, A., & Walsh, D. A. (2014). Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis. Annals of the Rheumatic Diseases, 73(9), 1710-1718. https://doi.org/10.1136/annrheumdis-2013-203416

Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC (2013)
Journal Article
Verma, C., Eremin, J. M., Robins, A., Bennett, A. J., Cowley, G. P., El-Sheemy, M. A., …Eremin, O. (2013). Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC. Journal of Translational Medicine, 11(16), https://doi.org/10.1186/1479-5876-11-16

Background: Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women with large and locally advanc... Read More about Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S., Norris, L. M., Pearson, R. G., …Chapman, V. (2010). Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis and Rheumatism, 62(12), https://doi.org/10.1002/art.27698

Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.