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A data mining tool for detecting and predicting abnormal behaviour of railway tunnels (2017)
Conference Proceeding
Vagnoli, M., Remenyte-Prescott, R., Thompson, D., Andrews, J., Clarke, P., & Atkinson, N. (2017). A data mining tool for detecting and predicting abnormal behaviour of railway tunnels.

The UK railway network is subjected to an electrification process that aims to electrify most of the network by 2020. This upgrade will improve the capacity, reliability and efficiency of the transportation system by providing cleaner, quicker and mo... Read More about A data mining tool for detecting and predicting abnormal behaviour of railway tunnels.

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator (2017)
Journal Article
McMillan, B., Gavaghan, D. J., & Mirams, G. R. (2017). Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator. Toxicology Research, 6, 912-921. https://doi.org/10.1039/C7TX00141J

Drug-induced Torsades de Pointes (TdP) arrhythmia is of major interest in predictive toxicology. Drugs which cause TdP block the hERG cardiac potassium channel. However, not all drugs that block hERG cause TdP. As such, further understanding of the m... Read More about Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator.

Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans (2017)
Journal Article
Law, J., Morris, D. E., Izzi Engbeaya, C., Salem, V., Coello, C., Robinson, L. J., …Symonds, M. E. (2018). Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans. Journal of Nuclear Medicine, 59(3), https://doi.org/10.2967/jnumed.117.190546

Background Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BA... Read More about Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans.

Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination (2017)
Journal Article
Blair, G. W., Appleton, J. P., Law, Z. K., Doubal, F., Flaherty, K., Dooley, R., …Wardlaw, J. M. (2018). Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. International Journal of Stroke, 13(5), 530-538. https://doi.org/10.1177/1747493017731947

Rationale The pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to differ from large artery atherothrombo- or cardio-embolic stroke. Licensed drugs, isosorbide mononitrate and cilostazol, have promising mechanisms... Read More about Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.

N1 responses to images of hands in occipito-temporal event-related potentials (2017)
Journal Article
Espírito Santo, M. G., Maxim, O. S., & Schürmann, M. (2017). N1 responses to images of hands in occipito-temporal event-related potentials. Neuropsychologia, 106, https://doi.org/10.1016/j.neuropsychologia.2017.09.012

Hands, much like faces, convey social information, instructions and intentions to an observer. While the neural processes of face perception have been widely studied, it was only recently that fMRI identified occipito-temporal areas sensitive to stat... Read More about N1 responses to images of hands in occipito-temporal event-related potentials.

Identity and naming practices in British marriage and civil partnerships (2017)
Journal Article
Jones, L., Mills, S., Paterson, L. L., Turner, G., & Coffey-Glover, L. (2017). Identity and naming practices in British marriage and civil partnerships. Gender and Language, 11(3), https://doi.org/10.1558/genl.27916

This article demonstrates the continued prevalence of traditional, heteronormative practices regarding marriage and naming practices in Britain, and also considers the complex choices made by same-sex couples who marry in relation to whether there ar... Read More about Identity and naming practices in British marriage and civil partnerships.

Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease (2017)
Journal Article
Boden, K. A., Barber, I. S., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., …Bottley, A. (2017). Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 1(1), https://doi.org/10.3233/ADR-170015

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD), however the drivers of this disease remains enigmatic. Genome wide association and in-vivo modelling have shown that loss-of-function e.g. ABCA7, reduced levels of SIRT1,... Read More about Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease.

Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis (2017)
Journal Article
Contente, M. L., Dall'Oglio, F., Tamborini, L., Molinari, F., & Paradisi, F. (in press). Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis. ChemCatChem, https://doi.org/10.1002/cctc.201701147

A new mild and efficient process for the preparation of aldehydes in water employed as flavour and fragrance components in food, beverage, cosmetics, as well as in pharmaceuticals was developed using a continuous-flow approach based on an immobilized... Read More about Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis.

Ground motion in areas of abandoned mining: application of the intermittent SBAS (ISBAS) to the Northumberland and Durham coalfield, UK (2017)
Journal Article
Gee, D., Bateson, L., Sowter, A., Grebby, S., Novellino, A., Cigna, F., …Wyatt, L. (2017). Ground motion in areas of abandoned mining: application of the intermittent SBAS (ISBAS) to the Northumberland and Durham coalfield, UK. Geosciences, 7(3), https://doi.org/10.3390/geosciences7030085

In this paper, we investigate land motion and groundwater level change phenomena using differential interferometric synthetic aperture radar (DInSAR) over the Northumberland and Durham coalfield in the United Kingdom. The study re-visits earlier res... Read More about Ground motion in areas of abandoned mining: application of the intermittent SBAS (ISBAS) to the Northumberland and Durham coalfield, UK.

Cultural specificity versus institutional universalism: a critique of the National Integrity System (NIS) methodology (2017)
Journal Article
Heywood, P. M., & Johnston, E. (in press). Cultural specificity versus institutional universalism: a critique of the National Integrity System (NIS) methodology. Crime, Law and Social Change, 68(3), https://doi.org/10.1007/s10611-017-9709-z

This article provides an assessment and critique of the National Integrity System approach and methodology, informed by the experience of conducting an NIS review in Cambodia. It explores four key issues that potentially undermine the relevance and... Read More about Cultural specificity versus institutional universalism: a critique of the National Integrity System (NIS) methodology.

Meso-scale defect evaluation of selective laser melting using spatially resolved acoustic spectroscopy (2017)
Journal Article
Hirsch, M., Catchpole-Smith, S., Patel, R., Marrow, P., Li, W., Tuck, C., …Clare, A. T. (2017). Meso-scale defect evaluation of selective laser melting using spatially resolved acoustic spectroscopy. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 473(2205), https://doi.org/10.1098/rspa.2017.0194

Developments in additive manufacturing technology are serving to expand the potential applications. Critical developments are required in the supporting areas of measurement and in process inspection to achieve this. CM247LC is a nickel superalloy th... Read More about Meso-scale defect evaluation of selective laser melting using spatially resolved acoustic spectroscopy.

Understanding technology adoption and use by healthcare proferssionals using models of technology acceptance and q-methodology (2017)
Conference Proceeding
Ladan, M. A., Wharrad, H., & Windle, R. (2017). Understanding technology adoption and use by healthcare proferssionals using models of technology acceptance and q-methodology.

This study explores the use of models of technology acceptance (TAM and UTAUT) to understand technology adoption and use among healthcare professionals (HCPs) in the clinical area in Sub-Saharan Africa (SSA). Six themes were developed from both model... Read More about Understanding technology adoption and use by healthcare proferssionals using models of technology acceptance and q-methodology.

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma (2017)
Journal Article
Matthey, M., Roberts, R., Seidinger, A., Simon, A., Schröder, R., Kuschak, M., …Wenzel, D. (in press). Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Science Translational Medicine, 9(407), https://doi.org/10.1126/scitranslmed.aag2288

Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine nucleotide–bindin... Read More about Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

6,7-seco-ent-kauranoids derived from oridonin as potential anticancer agents (2017)
Journal Article
Xu, S., Yao, H., Hu, M., Li, D., Zhu, Z., Xie, W., …Xu, J. (in press). 6,7-seco-ent-kauranoids derived from oridonin as potential anticancer agents. Journal of Natural Products, https://doi.org/10.1021/acs.jnatprod.7b00057

Structurally unique 6,7-seco-ent-kaurenes, which are widely distributed in the genus Isodon, have attracted considerable attention because of their antitumor activities. Previously, a convenient conversion of commercially available oridonin (1) to 6,... Read More about 6,7-seco-ent-kauranoids derived from oridonin as potential anticancer agents.

A comparison study of the blower door and novel pulse technique on measuring enclosure airtightness in a controlled environment (2017)
Conference Proceeding
Zheng, X., Cooper, E., Mazzon, J., Wallis, I., & Wood, C. J. (2017). A comparison study of the blower door and novel pulse technique on measuring enclosure airtightness in a controlled environment.

This paper introduces a comparison study of measuring the airtightness of a house sized test chamber using the novel pulse technique and the standard blower door method in a controlled environment. Eight different testing plates have been applied to... Read More about A comparison study of the blower door and novel pulse technique on measuring enclosure airtightness in a controlled environment.

Beyond the ontological turn: affirming the relative autonomy of politics (2017)
Journal Article
Khan, G. A. (2017). Beyond the ontological turn: affirming the relative autonomy of politics. Political Studies Review, 15(4), 551-563. https://doi.org/10.1177/1478929917712933

In this article, I critically evaluate a characteristic tendency that is found across the various traditions of poststructuralism, both narrowly and more broadly defined. This is an increasing propensity to be preoccupied with ontological questions a... Read More about Beyond the ontological turn: affirming the relative autonomy of politics.

A robust upscaling of the effective particle deposition rate in porous media (2017)
Journal Article
Boccardo, G., Crevacore, E., Sethi, R., & Icardi, M. (2018). A robust upscaling of the effective particle deposition rate in porous media. Journal of Contaminant Hydrology, 212, https://doi.org/10.1016/j.jconhyd.2017.09.002

In the upscaling from pore- to continuum (Darcy) scale, reaction and deposition phenomena at the solid-liquid interface of a porous medium have to be represented by macroscopic reaction source terms. The effective rates can be computed, in the case o... Read More about A robust upscaling of the effective particle deposition rate in porous media.