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LMISA: A Lightweight Multi-modality Image Segmentation Network via Domain Adaptation using Gradient Magnitude and Shape Constraint (2022)
Journal Article
Jafari, M., Francis, S., Garibaldi, J. M., & Chen, X. (2022). LMISA: A Lightweight Multi-modality Image Segmentation Network via Domain Adaptation using Gradient Magnitude and Shape Constraint. Medical Image Analysis, 81, Article 102536. https://doi.org/10.1016/j.media.2022.102536

In medical image segmentation, supervised machine learning models trained using one image modality (e.g. computed tomography (CT)) are often prone to failure when applied to another image modality (e.g. magnetic resonance imaging (MRI)) even for the... Read More about LMISA: A Lightweight Multi-modality Image Segmentation Network via Domain Adaptation using Gradient Magnitude and Shape Constraint.

Diagnostic utility of artificial intelligence for left ventricular scar identification using cardiac magnetic resonance imaging—A systematic review (2021)
Journal Article
Jathanna, N., Podlasek, A., Sokol, A., Auer, D., Chen, X., & Jamil-Copley, S. (2021). Diagnostic utility of artificial intelligence for left ventricular scar identification using cardiac magnetic resonance imaging—A systematic review. Cardiovascular Digital Health Journal, 2(6), S21-S29. https://doi.org/10.1016/j.cvdhj.2021.11.005

Background: Accurate, rapid quantification of ventricular scar using cardiac magnetic resonance imaging (CMR) carries importance in arrhythmia management and patient prognosis. Artificial intelligence (AI) has been applied to other radiological chall... Read More about Diagnostic utility of artificial intelligence for left ventricular scar identification using cardiac magnetic resonance imaging—A systematic review.

FuzzyDCNN: Incorporating Fuzzy Integral Layers to Deep Convolutional Neural Networks for Image Segmentation (2021)
Conference Proceeding
Lin, Q., Chen, X., Chen, C., & Garibaldi, J. M. (2021). FuzzyDCNN: Incorporating Fuzzy Integral Layers to Deep Convolutional Neural Networks for Image Segmentation. In 2021 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE). https://doi.org/10.1109/fuzz45933.2021.9494456

Convolutional neural networks (CNNs) have achieved the state-of-the-art performance in many application areas, due to the capability of automatically extracting and aggregating spatial and channel-wise features from images. Most recent studies have c... Read More about FuzzyDCNN: Incorporating Fuzzy Integral Layers to Deep Convolutional Neural Networks for Image Segmentation.

Deep Learning with Dynamically Weighted Loss Function for Sensor-Based Prognostics and Health Management (2020)
Journal Article
Rengasamy, D., Jafari, M., Rothwell, B., Chen, X., & Figueredo, G. P. (2021). Deep Learning with Dynamically Weighted Loss Function for Sensor-Based Prognostics and Health Management. Sensors, 20(3), https://doi.org/10.3390/s20030723

Deep learning has been employed to prognostic and health management of automotive and aerospace with promising results. Literature in this area has revealed that most contributions regarding deep learning is largely focused on the model’s architectur... Read More about Deep Learning with Dynamically Weighted Loss Function for Sensor-Based Prognostics and Health Management.

FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net (2019)
Book Chapter
Jafari, M., Li, R., Xing, Y., Auer, D., Francis, S., Garibaldi, J., & Chen, X. (2019). FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net. In Image and Graphics: 10th International Conference, ICIG 2019, Beijing, China, August 23–25, 2019, Proceedings, Part II (529-537). Springer Verlag. https://doi.org/10.1007/978-3-030-34110-7_44

© 2019, Springer Nature Switzerland AG. In this paper, we present a generic deep convolutional neural network (DCNN) for multi-class image segmentation. It is based on a well-established supervised end-to-end DCNN model, known as U-net. U-net is firs... Read More about FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net.

Dual Adaptive Pyramid Network for Cross-Stain Histopathology Image Segmentation (2019)
Book Chapter
Hou, X., Liu, J., Xu, B., Liu, B., Chen, X., Garibaldi, J., …Qiu, G. (2019). Dual Adaptive Pyramid Network for Cross-Stain Histopathology Image Segmentation. In Medical Image Computing and Computer Assisted Intervention – MICCAI 2019: 22nd International Conference, Shenzhen, China, October 13–17, 2019, Proceedings, Part II (101-109). Springer Verlag. https://doi.org/10.1007/978-3-030-32245-8_12

Supervised semantic segmentation normally assumes the test data being in a similar data domain as the training data. However, in practice, the domain mismatch between the training and unseen data could lead to a significant performance drop. Obtainin... Read More about Dual Adaptive Pyramid Network for Cross-Stain Histopathology Image Segmentation.

A Novel Weighted Combination Method for Feature Selection using Fuzzy Sets (2019)
Conference Proceeding
Shen, Z., Chen, X., & Garibaldi, J. M. (2019). A Novel Weighted Combination Method for Feature Selection using Fuzzy Sets. In 2019 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE) (1-6). https://doi.org/10.1109/FUZZ-IEEE.2019.8858890

In this paper, we propose a novel weighted combination feature selection method using bootstrap and fuzzy sets. The proposed method mainly consists of three processes, including fuzzy sets generation using bootstrap, weighted combination of fuzzy set... Read More about A Novel Weighted Combination Method for Feature Selection using Fuzzy Sets.

Performance Optimization of a Fuzzy Entropy Based Feature Selection and Classification Framework (2019)
Conference Proceeding
Shen, Z., Chen, X., & Garibaldi, J. (2019). Performance Optimization of a Fuzzy Entropy Based Feature Selection and Classification Framework. . https://doi.org/10.1109/SMC.2018.00238

© 2018 IEEE. In this paper, based on a fuzzy entropy feature selection framework, different methods have been implemented and compared to improve the key components of the framework. Those methods include the combinations of three ideal vector calcul... Read More about Performance Optimization of a Fuzzy Entropy Based Feature Selection and Classification Framework.

Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site (2018)
Journal Article
Chen, X., Abbey, S., Bharmal, A., Harris, S., Hudson, E., Krinner, L., …Billeter, R. (2019). Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site. Scandinavian Journal of Medicine and Science in Sports, 29(4), 504-514. https://doi.org/10.1111/sms.13369

A density model of neurovascular structures was generated from 28 human vastus lateralis muscles isolated from embalmed cadavers. The intramuscular portion of arteries, veins and nerves was dissected, traced on transparencies and digitised before adj... Read More about Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site.

Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy (2018)
Journal Article
Chen, X., Graham, J., Petropoulos, I. N., Ponirakis, G., Asghar, O., & Alam, U. (2018). Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy. Investigative Ophthalmology & Visual Science, 59(2), https://doi.org/10.1167/iovs.17-23342

Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We have evaluated the diagnostic performance of previously established CC... Read More about Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy.

Efficient deformable motion correction for 3-D abdominal MRI using manifold regression (2017)
Conference Proceeding
Chen, X., Balfour, D. R., Marsden, P. K., Reader, A. J., Prieto, C., & King, A. P. (in press). Efficient deformable motion correction for 3-D abdominal MRI using manifold regression.

We present a novel framework for efficient retrospective respiratory motion correction of 3-D abdominal MRI using manifold regression. K-space data are continuously acquired under free breathing using the stack-of-stars radial gold-en-angle trajector... Read More about Efficient deformable motion correction for 3-D abdominal MRI using manifold regression.

High-resolution self-gated dynamic abdominal MRI using manifold alignment (2017)
Journal Article
Chen, X., Usman, M., Baumgartner, C. F., Balfour, D. R., Marsden, P. K., Reader, A. J., …King, A. P. (2017). High-resolution self-gated dynamic abdominal MRI using manifold alignment. IEEE Transactions on Medical Imaging, 36(4), https://doi.org/10.1109/TMI.2016.2636449

We present a novel retrospective self-gating method based on manifold alignment (MA), which enables reconstruction of free-breathing, high spatial and temporal resolution abdominal MRI sequences. Based on a radial golden-angle (RGA) acquisition traje... Read More about High-resolution self-gated dynamic abdominal MRI using manifold alignment.

A fully automatic nerve segmentation and morphometric parameter quantification system for early diagnosis of diabetic neuropathy in corneal images (2016)
Journal Article
Al-Fahdawi, S., Qahwaji, R., Al-Waisy, A. S., Ipson, S., Malik, R. A., Brahma, A., & Chen, X. (2016). A fully automatic nerve segmentation and morphometric parameter quantification system for early diagnosis of diabetic neuropathy in corneal images. Computer Methods and Programs in Biomedicine, 135, https://doi.org/10.1016/j.cmpb.2016.07.032

Diabetic Peripheral Neuropathy (DPN) is one of the most common types of diabetes that can affect the cornea. An accurate analysis of the nerve structures can assist the early diagnosis of this disease. This paper proposes a robust, fast and fully aut... Read More about A fully automatic nerve segmentation and morphometric parameter quantification system for early diagnosis of diabetic neuropathy in corneal images.

An automatic tool for quantification of nerve fibers in corneal confocal microscopy images (2016)
Journal Article
Chen, X., Graham, J., Dabbah, M., Petropoulos, I. N., Tavakoli, M., & Malik, R. (2016). An automatic tool for quantification of nerve fibers in corneal confocal microscopy images. IEEE Transactions on Biomedical Engineering, 64(4), 786-794. https://doi.org/10.1109/TBME.2016.2573642

Objective: We describe and evaluate an automated software tool for nerve-fiber detection and quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve- fiber detection with morphological descriptors. Method: We have evalua... Read More about An automatic tool for quantification of nerve fibers in corneal confocal microscopy images.

Determining the lower limit of Liangzhu culture based on black carbon purification with hydropyrolysis technique (2015)
Journal Article
Zhang, X., Huang, D., Han Deng, H., Snape, C., Meredith, W., Zhao, Y., …Sun, Y. (2015). Determining the lower limit of Liangzhu culture based on black carbon purification with hydropyrolysis technique. Quaternary Geochronology, 30(A), https://doi.org/10.1016/j.quageo.2015.07.001

Located in the middle and lower reaches of the Yangtze River, the Liangzhu Culture was one of the most important Neolithic cultures at the dawn of Chinese civilization. However, uncertainty over the lower age limit ending the Liangzhu Culture has res... Read More about Determining the lower limit of Liangzhu culture based on black carbon purification with hydropyrolysis technique.

Small nerve fibre quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fibre density (2015)
Journal Article
Chen, X., Graham, J., Dabbah, M., Petropoulos, I. N., Ponirakis, G., Asghar, O., …Malik, R. A. (2015). Small nerve fibre quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fibre density. Diabetes Care, 38(6), 1138-1144. https://doi.org/10.2337/dc14-2422

OBJECTIVE: Quantitative assessment of small fiber damage is key to the early diagnosis and assessment of progression or regression of diabetic sensorimotor polyneuropathy (DSPN). Intraepidermal nerve fiber density (IENFD) is the current gold standard... Read More about Small nerve fibre quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fibre density.

Application of RELUX simulation to investigate energy saving potential from daylighting in a new educational building in UK (2014)
Journal Article
Yu, X., Su, Y., & Chen, X. (2014). Application of RELUX simulation to investigate energy saving potential from daylighting in a new educational building in UK. Energy and Buildings, 74, https://doi.org/10.1016/j.enbuild.2014.01.024

Daylighting is a renewable energy solution for illumination and visual comfort in buildings. Daylighting performance and its induced energy saving largely depends on various factors, including room geometry, window-to-wall ratio, window transmittance... Read More about Application of RELUX simulation to investigate energy saving potential from daylighting in a new educational building in UK.

Automatic generation of statistical pose and shape models for articulated joints (2013)
Journal Article
Chen, X., Graham, J., Hutchinson, C., & Muir, L. (2013). Automatic generation of statistical pose and shape models for articulated joints. IEEE Transactions on Medical Imaging, 33(2), https://doi.org/10.1109/TMI.2013.2285503

Statistical analysis of motion patterns of body joints is potentially useful for detecting and quantifying pathologies. However, building a statistical motion model across different subjects remains a challenging task, especially for a complex joint... Read More about Automatic generation of statistical pose and shape models for articulated joints.

Automatic inference and measurement of 3D carpal bone kinematics from single view fluoroscopic sequences (2012)
Journal Article
Chen, X., Graham, J., Hutchinson, C., & Muir, L. (2012). Automatic inference and measurement of 3D carpal bone kinematics from single view fluoroscopic sequences. IEEE Transactions on Medical Imaging, 32(2), https://doi.org/10.1109/TMI.2012.2226740

We present a novel framework for estimating the 3D poses and shapes of the carpal bones from single view fluoroscopic sequences. A hybrid statistical model representing both the pose and shape variation of the carpal bones is built, based on a number... Read More about Automatic inference and measurement of 3D carpal bone kinematics from single view fluoroscopic sequences.