All Outputs (10)

Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis (2021)
Journal Article
Bestwick-Stevenson, T., Ifesemen, O. S., Pearson, R. G., & Edwards, K. L. (2021). Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis. Orthopaedic Journal of Sports Medicine, 9(6), Article 23259671211004554. https://doi.org/10.1177/23259671211004554

Background: The association between participating in sport and osteoarthritis is not fully understood. Purpose: To investigate the association between osteoarthritis and participating in sports not listed in previous reviews: American footba... Read More about Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis.

Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis (2021)
Journal Article
Bestwick-Stevenson, T., Ifesemen, O. S., Pearson, R. G., & Edwards, K. L. (2021). Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis. Orthopaedic Journal of Sports Medicine, 9(6), 1-15. https://doi.org/10.1177/23259671211004554

Background: The association between participating in sport and osteoarthritis is not fully understood. Purpose: To investigate the association between osteoarthritis and participating in sports not listed in previous reviews: American football,... Read More about Association of Sports Participation With Osteoarthritis: A Systematic Review and Meta-Analysis.

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis (2019)
Journal Article
Pearson, R. G., Masud, T., Blackshaw, E., Naylor, A., Hinchcliffe, M., Jeffery, K., …Perkins, A. C. (2019). Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis. Pharmaceutics, 11(6), Article 265. https://doi.org/10.3390/pharmaceutics11060265

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati... Read More about Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis.

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis (2017)
Journal Article
Williams, A. J., Jordan, F., King, G., Lewis, A. L., Illum, L., Masud, T., …Pearson, R. G. (in press). In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis. International Journal of Pharmaceutics, https://doi.org/10.1016/j.ijpharm.2017.10.029

Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient... Read More about In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis.

A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures (2017)
Journal Article
Khan, T., Grindlay, D. J., Scammell, B. E., Ollivere, B., Manktelow, A., & Pearson, R. G. (2017). A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures. Bone and Joint Journal, 99-B(4_Supple_B), 17-25. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-1311.R1

Aims The aim of this study was to investigate the outcomes of Vancouver type B2 and B3 fractures by performing a systematic review of the methods of surgical treatment which have been reported. Materials and Methods A systematic search was perform... Read More about A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures.

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis (2016)
Journal Article
Pearson, R. G., Clement, R., Edwards, K., & Scammell, B. E. (2016). Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis. BMJ Open, 6(11), Article e010303. https://doi.org/10.1136/bmjopen-2015-010303

Objectives: Systematic review and meta-analysis of published observational cohort studies. To quantify the increased risk smokers have of experiencing a delayed and/or non-union in fractures, spinal fusion, osteotomy, arthrodesis or established non-u... Read More about Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis.

Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers (2016)
Journal Article
Simpson, A., Pearson, R. G., & Scammell, B. (2016). Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers. Annals of Sports Medicine and Research, 3(7), Article 1087

Background: Mechanical hypoalgesia has been demonstrated following bouts of acute exercise. The pain relieving properties of exercise thus have the potential to be utilised to help manage painful musculoskeletal conditions, such as osteoarthritis. Th... Read More about Ten minutes ergometer rowing exercise increases pressure pain thresholds in high performance rowers.

Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence (2016)
Journal Article
Kurien, T., Kerslake, R., Haywood, B., Pearson, R. G., & Scammell, B. E. (2016). Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence. Case Reports in Orthopedics, 2016, 1-5. https://doi.org/10.1155/2016/6043497

We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replac... Read More about Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence.

Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department (2016)
Journal Article
Kurien, T., Price, K., Pearson, R. G., & Hunter, J. (in press). Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department. Bone and Joint Journal, 98B(1), https://doi.org/10.1302/0301-620X.98B1.36118

A retrospective study was performed in 100 children aged between two and 16 years, with a dorsally angulated stable fracture of the distal radius or forearm, who were treated with manipulation in the emergency department (ED) using intranasal diamorp... Read More about Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S., Norris, L. M., Pearson, R. G., …Chapman, V. (2010). Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis and Rheumatism, 62(12), https://doi.org/10.1002/art.27698

Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.