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Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator (2021)
Journal Article
Saeedi, A., Cummings, N. J., McLean, D., Connerton, I. F., & Connerton, P. L. (2021). Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator. Scientific Reports, 11, Article 21393. https://doi.org/10.1038/s41598-021-00865-8

A novel Gram-stain negative, aerobic, halotolerant, motile, rod-shaped, predatory bacterium ASxL5T, was isolated from a bovine slurry tank in Nottinghamshire, UK using Campylobacter hyointestinalis as prey. Other Campylobacter species and members of... Read More about Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator.

Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia (2020)
Journal Article
Chinivasagam, H. N., Estella, W., Maddock, L., Mayer, D. G., Weyand, C., Connerton, P. L., & Connerton, I. F. (2020). Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.00632

© Copyright © 2020 The State of Queensland (through the Department Agriculture and Fisheries). This study describes the development and use of bacteriophage cocktails to control Campylobacter in broiler chickens, in a commercial setting, in Queenslan... Read More about Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia.

Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy (2020)
Journal Article
Mohamed, A., Taha, O., El-Sherif, H. M., Connerton, P. L., Hooton, S. P., Bassim, N. D., …El-Shibiny, A. (2020). Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy. Viruses, 12(4), 1-20. https://doi.org/10.3390/v12040424

© 2020 by the authors. Developing novel antimicrobials capable of controlling multidrug-resistant bacterial pathogens is essential to restrict the use of antibiotics. Bacteriophages (phages) constitute a major resource that can be harnessed as an alt... Read More about Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy.

Development of a lyophilization process for Campylobacter bacteriophage storage and transport (2020)
Journal Article
Liang, L., Carrigy, N. B., Kariuki, S., Muturi, P., Onsare, R., Nagel, T., …Connerton, I. F. (2020). Development of a lyophilization process for Campylobacter bacteriophage storage and transport. Microorganisms, 8(2), 1-13. https://doi.org/10.3390/microorganisms8020282

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stabili... Read More about Development of a lyophilization process for Campylobacter bacteriophage storage and transport.

Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens (2020)
Journal Article
Flaujac Lafontaine, G. M., Connerton, I. F., Richards, P. J., Fish, N. M., Connerton, P. L., Cummings, N. J., …Connerton, I. F. (2020). Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.03030

© Copyright © 2020 Flaujac Lafontaine, Richards, Connerton, O’Kane, Ghaffar, Cummings, Fish and Connerton. Worldwide Campylobacter jejuni is a leading cause of foodborne disease. Contamination of chicken meat with digesta from C. jejuni-positive bird... Read More about Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens.

Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance (2020)
Journal Article
Connerton, I. F., Richards, P. J., Fish, N. M., Flaujac Lafontaine, G. M., Asiani, K., Connerton, P. L., …Richards, P. J. (2020). Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance. mSystems, 5(1), Article e00827-19. https://doi.org/10.1128/msystems.00827-19

Copyright © 2020 Richards et al Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens... Read More about Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance.

Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota (2019)
Journal Article
Richards, P. J., Connerton, P. L., & Connerton, I. F. (2019). Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota. Frontiers in Microbiology, 10, Article 476. https://doi.org/10.3389/fmicb.2019.00476

Bacteriophage biocontrol to reduce Campylobacter jejuni levels in chickens can reduce human exposure and disease acquired through the consumption of contaminated poultry products.Investigating changes in the chicken microbiota during phage treatment... Read More about Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota.

Bacteriophage ZCKP1: a potential treatment for Klebsiella pneumoniae isolated from diabetic foot patients (2018)
Journal Article
Taha, O. A., Connerton, P., Connerton, I., & El-Shibiny, A. (2018). Bacteriophage ZCKP1: a potential treatment for Klebsiella pneumoniae isolated from diabetic foot patients. Frontiers in Microbiology, 9, Article 2127. https://doi.org/10.3389/fmicb.2018.02127

The recorded growth in infection by multidrug resistant bacteria necessitates prompt efforts towards developing alternatives to antibiotics, such as bacteriophage therapy. Immuno-compromised patients with diabetes mellitus are particularly prone to f... Read More about Bacteriophage ZCKP1: a potential treatment for Klebsiella pneumoniae isolated from diabetic foot patients.

The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens (2018)
Journal Article
Connerton, P. L., Richards, P. J., Lafontaine, G. M., O'Kane, P. M., Ghaffar, N. M., Cummings, N. J., …Connerton, I. F. (in press). The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens. Microbiome, 6, Article 88. https://doi.org/10.1186/s40168-018-0477-5

Background Campylobacters are an unwelcome member of the poultry gut microbiota in terms of food safety. The objective of this study was to compare the microbiota, inflammatory responses, and zootechnical parameters of broiler chickens not exposed t... Read More about The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens.

Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol (2016)
Journal Article
Firlieyanti, A. S., Connerton, P. L., & Connerton, I. F. (2016). Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol. International Journal of Food Microbiology, 237, 121-127. https://doi.org/10.1016/j.ijfoodmicro.2016.08.026

Consumption of foods containing chicken liver has been associated with Campylobacter enteritis. Campylobacters can contaminate the surface of livers post-mortem but can also arise through systemic infection of colonising bacteria in live birds. The u... Read More about Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol.

Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 (2016)
Journal Article
Anjum, A., Kelly, B., Aidley, J. B., Connerton, P. L., Cummings, N. J., Parkhill, J., …Bayliss, C. D. (2016). Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168. Nucleic Acids Research, https://doi.org/10.1093/nar/gkw019

Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences. Phase-variable meth... Read More about Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168.

Filamentation of Campylobacter in broth cultures (2015)
Journal Article
Ghaffar, N. M., Connerton, P. L., & Connerton, I. F. (2015). Filamentation of Campylobacter in broth cultures. Frontiers in Microbiology, 6(657), https://doi.org/10.3389/fmicb.2015.00657

The transition from rod to filamentous cell morphology has been identified as a response to stressful conditions in many bacterial species and has been ascribed to confer certain survival advantages. Filamentation of Campylobacter jejuni was demonstr... Read More about Filamentation of Campylobacter in broth cultures.

Host adaption to the bacteriophage carrier state of Campylobacter jejuni (2015)
Journal Article
Brathwaite, K. J., Siringan, P., Connerton, P. L., & Connerton, I. F. (2015). Host adaption to the bacteriophage carrier state of Campylobacter jejuni. Research in Microbiology, 166(6), 504-515. https://doi.org/10.1016/j.resmic.2015.05.003

The carrier state of the foodborne pathogen Campylobacter jejuni represents an alternative life cycle whereby virulent bacteriophage can persistent in association with host bacteria without commitment to lysogeny. Host bacteria exhibit significant ph... Read More about Host adaption to the bacteriophage carrier state of Campylobacter jejuni.

Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni (2014)
Journal Article
Siringan, P., Connerton, P. L., Cummmings, N. J., & Connerton, I. F. (2014). Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni. Open Biology, 4(3), Article 130200. https://doi.org/10.1098/rsob.130200

Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding... Read More about Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni.

Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens (2005)
Journal Article
Loc Carrillo, C., Atterbury, R. J., El-Shibiny, A., Connerton, P. L., Dillon, E., Scott, A., & Connerton, I. F. (2005). Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens. Applied and Environmental Microbiology, 71(11), https://doi.org/10.1128/AEM.71.11.6554-6563.2005

Colonization of broiler chickens by the enteric pathogen Campylobacter jejuni is widespread and difficult to prevent. Bacteriophage therapy is one possible means by which this colonization could be controlled, thus limiting the entry of campylobacter... Read More about Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens.

Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca (2005)
Journal Article
Atterbury, R. J., Dillon, E., Swift, C., Connerton, P. L., Frost, J., Dodd, C. E., …Connerton, I. F. (2005). Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca. Applied and Environmental Microbiology, 71(8), https://doi.org/10.1128/AEM.71.8.4885-4887.2005

Campylobacter jejuni and Campylobacter-specific bacteriophage were enumerated from broiler chicken ceca selected from 90 United Kingdom flocks (n = 205). C. jejuni counts in the presence of bacteriophage (mean log10 5.1 CFU/g) were associated with a... Read More about Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca.

Application of host-specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni (2003)
Journal Article
Atterbury, R. J., Connerton, P. L., Dodd, C. E., Rees, C. E., & Connerton, I. F. (2003). Application of host-specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni. Applied and Environmental Microbiology, 69(10), https://doi.org/10.1128/AEM.69.10.6302-6306.2003

Retail poultry products are widely purported as the major infection vehicle for human campylobacteriosis. Numerous intervention strategies have sought to reduce Campylobacter contamination on broiler carcasses in the abattoir. This study reports the... Read More about Application of host-specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni.

Isolation and characterization of Campylobacter bacteriophages from retail poultry (2003)
Journal Article
Atterbury, R. J., Connerton, P. L., Dodd, C. E., Rees, C. E., & Connerton, I. F. (2003). Isolation and characterization of Campylobacter bacteriophages from retail poultry. Applied and Environmental Microbiology, 69(8), https://doi.org/10.1128/AEM.69.8.4511-4518.2003

The ability of phages to survive processing is an important aspect of their potential use in the biocontrol of Campylobacter in poultry production. To this end, we have developed a procedure to recover Campylobacter bacteriophages from chilled and fr... Read More about Isolation and characterization of Campylobacter bacteriophages from retail poultry.