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All Outputs (6)

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection (2020)
Journal Article
Sweeney, E., Harrington, N. E., Harley Henriques, A. G., Hassan, M. M., Crealock-Ashurst, B., Smyth, A. R., …Harrison, F. (2021). An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection. Microbiology, 167(1), Article 000987. https://doi.org/10.1099/mic.0.000987

Staphylococcus aureus is the most prevalent organism isolated from the airways of people with cystic fibrosis (CF), predomi-nantly early in life. Yet its role in the pathology of lung disease is poorly understood. In mice, and many experiments using... Read More about An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection.

Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor? (2018)
Journal Article
Hurley, M. N., & Smyth, A. R. (2018). Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?. Current Opinion in Pulmonary Medicine, 24(6), 586-591. https://doi.org/10.1097/MCP.0000000000000518

Purpose of review: describe why this review is timely and relevant. The cystic fibrosis lung has long been appreciated as a competitive niche for complex interactions between bacterial species. The individual relationships between effects on the host... Read More about Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?.

Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis (2017)
Journal Article
Hurley, M., Fogarty, A. W., McKeever, T. M., Goss, C., Rosenfeld, M., & Smyth, A. R. (in press). Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis. Annals of the American Thoracic Society, https://doi.org/10.1513/AnnalsATS.201705-376OC

Rationale: Consensus is lacking regarding anti-staphylococcal antibiotic prophylaxis use for young children with cystic fibrosis. Prophylaxis is recommended in the UK, but recommended against in the US. Objectives: To test the hypothesis that anti-... Read More about Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis.

Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study (2014)
Journal Article
Hurley, M., McKeever, T. M., Prayle, A. P., Smyth, A. R., & Fogarty, A. W. (2014). Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study. Journal of Cystic Fibrosis, 13(4), https://doi.org/10.1016/j.jcf.2013.12.002

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement. Method: Death registration data analysis (US, England & Wa... Read More about Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study.

A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms (2011)
Journal Article
Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., …Reymond, J. (2011). A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50(45), https://doi.org/10.1002/anie.201104342

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P.?aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the l... Read More about A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms.

Research Protocol - Effect of anti-staphylococcal antibiotic prophylaxis upon isolation and colonisation with Staphylococcus aureus, Pseudomonas aeruginosa and their resistant variants in cystic fibrosis
Other
Hurley, M., Smyth, A. R., Fogarty, A. W., McKeever, T. M., Rosenfeld, M., & Goss, C. (2016). Research Protocol - Effect of anti-staphylococcal antibiotic prophylaxis upon isolation and colonisation with Staphylococcus aureus, Pseudomonas aeruginosa and their resistant variants in cystic fibrosis