All Outputs (2)

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging (2021)
Journal Article
Martinez De La Cruz, B., Markus, R., Malla, S., Haig, M. I., Gell, C., Sang, F., …Knight, H. M. (2021). Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging. Molecular Psychiatry, 26(12), 7141-7153. https://doi.org/10.1038/s41380-021-01282-z

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapse... Read More about Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging.

Cardiac troponin T is necessary for normal development in the embryonic chick heart (2016)
Journal Article
England, J., Pang, K. L., Parnall, M., Haig, M. I., & Loughna, S. (in press). Cardiac troponin T is necessary for normal development in the embryonic chick heart. Journal of Anatomy, https://doi.org/10.1111/joa.12486

The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric protei... Read More about Cardiac troponin T is necessary for normal development in the embryonic chick heart.