All Outputs (8)

Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression (2020)
Journal Article
Villota, S. D., Toledo-Rodriguez, M., & Leach, L. (2021). Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression. Diabetologia, 64, 195-210. https://doi.org/10.1007/s00125-020-05290-6

© 2020, The Author(s). Aims/hypothesis: Reduced occupancy of junctional occludin is a feature of human placental vessels in the diabetic milieu. However, the functional consequence of this and whether this loss is due to differential expression of oc... Read More about Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.

The haemodynamics of the human placenta in utero (2020)
Journal Article
Dellschaft, N. S., Hutchinson, G., Shah, S., Jones, N. W., Bradley, C., Leach, L., …Gowland, P. A. (2020). The haemodynamics of the human placenta in utero. PLoS Biology, 18(5), Article e3000676. https://doi.org/10.1371/journal.pbio.3000676

© 2020 Dellschaft et al. We have used magnetic resonance imaging (MRI) to provide important new insights into the function of the human placenta in utero. We have measured slow net flow and high net oxygenation in the placenta in vivo, which are cons... Read More about The haemodynamics of the human placenta in utero.

Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway (2019)
Journal Article
Boardman, R., Pang, V., Malhi, N., Lynch, A. P., Leach, L., Benest, A. V., …Machado, M. J. (2019). Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway. AJP - Heart and Circulatory Physiology, 316(5), H1065-H1075. https://doi.org/10.1152/ajpheart.00610.2018

© 2019 the American Physiological Society. The Notch ligand delta-like ligand 4 (Dll4), upregulated by VEGF, is a key regulator of vessel morphogenesis and function, controlling tip and stalk cell selection during sprouting angiogenesis. Inhibition o... Read More about Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway.

Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes (2018)
Journal Article
Razak, A. A., Leach, L., & Ralevic, V. (2018). Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes. Diabetes and Vascular Disease Research, 15(6), 528-540. https://doi.org/10.1177/1479164118790904

Background: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplac... Read More about Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes.

Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin (2017)
Journal Article
Pang, V., Bates, D. O., & Leach, L. (2017). Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin. Clinical Science, 131(23), 2763-2775. https://doi.org/10.1042/CS20171252

The human placenta nourishes and protects the developing fetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the VEGF family including the pro-angiogenic/pro-permeability VEGF-A165a isoform, the anti-angi... Read More about Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin.

Transendothelial migration of human umbilical mesenchymal stem cells across uterine endothelial monolayers: junctional dynamics and putative mechanisms (2016)
Journal Article
Ebrahim, N. A., & Leach, L. (2016). Transendothelial migration of human umbilical mesenchymal stem cells across uterine endothelial monolayers: junctional dynamics and putative mechanisms. Placenta, 48, 87-98. https://doi.org/10.1016/j.placenta.2016.10.014

Introduction: During pregnancy, fetal stem cells can transfer to the maternal circulation and participate in tissue repair. How they transmigrate across maternal endothelial barriers and whether they can subsequently influence maternal endothelial in... Read More about Transendothelial migration of human umbilical mesenchymal stem cells across uterine endothelial monolayers: junctional dynamics and putative mechanisms.

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy (2016)
Journal Article
Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., …Leach, L. (in press). An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology, https://doi.org/10.1016/j.reprotox.2016.06.006

tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of pr... Read More about An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy.

Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers (2014)
Journal Article
Ebrahim, N. A., & Leach, L. (2015). Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers. Stem Cells and Development, 24(4), https://doi.org/10.1089/scd.2014.0207

Mesenchymal stem cells from Wharton’s jelly of human umbilical cords (WJ-MSC) are a valuable alternate source of stem cells. Their role in situ and whether they can interact and cross intact endothelial monolayers requires elucidation. The aim of thi... Read More about Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers.