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Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote (2025)
Journal Article
Banda, J., Ghosh, S., Roy, D., Ingole, K. D., Clark, L., Sharma, E., Kakkunath, S., Sue-Ob, K., Bhosale, R., Band, L., Ghosh, S., Wells, D., Atkinson, J., Provart, N. J., Bennett, M. J., Lilley, K. S., Jones, A., De Lucas, M., Bishopp, A., & Sadanandom, A. (2025). Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote. Science Advances, 11(35), eadw9153. https://doi.org/10.1126/sciadv.adw9153

SUMOylation is essential in plant and animal cells, but it remains unknown how small ubiquitin-like modifier (SUMO) components act in concert to modify specific targets in response to environmental stresses. In this study, we characterize every SUMO... Read More about Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote.

Taylor Dispersion in Osmotically Driven Flows with Solute Leakage (2025)
Journal Article
Jepson, J. M., & Band, L. R. (2025). Taylor Dispersion in Osmotically Driven Flows with Solute Leakage. Physics of Fluids, 37, 071915. https://doi.org/10.1063/5.0269906

The phloem facilitates the transport of solute from mature leaves throughout the plant for growth and maintenance. Solute is loaded into the phloem, which drives water influx via osmosis, thereby increasing the phloem pressure. The resulting pressure... Read More about Taylor Dispersion in Osmotically Driven Flows with Solute Leakage.

A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release (2024)
Journal Article
Pandey, S. K., Maurya, J. P., Aryal, B., Drynda, K., Nair, A., Miskolczi, P., Singh, R. K., Wang, X., Ma, Y., de Souza Moraes, T., Bayer, E. M., Farcot, E., Bassel, G. W., Band, L. R., & Bhalerao, R. P. (2024). A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release. EMBO Journal, 43(23), 5793-5812. https://doi.org/10.1038/s44318-024-00256-5

The control of cell–cell communication via plasmodesmata (PD) plays a key role in plant development. In tree buds, low-temperature conditions (LT) induce a switch in plasmodesmata from a closed to an open state, which restores cell-to-cell communicat... Read More about A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release.

Are we focusing on the right parameters? Insights from Global Sensitivity Analysis of a Functional-Structural Plant Model (2024)
Journal Article
Rutjens, R. J. L., Evers, J. B., Band, L. R., Jones, M. D., & Owen, M. R. (2024). Are we focusing on the right parameters? Insights from Global Sensitivity Analysis of a Functional-Structural Plant Model. in silico Plants, 6(2), diae011. https://doi.org/10.1093/insilicoplants/diae011

Performing global sensitivity analysis on functional-structural plant models (FSP models) can greatly benefit both model development and analysis by identifying the relevance of parameters for specific model outputs. Setting unimportant parameters to... Read More about Are we focusing on the right parameters? Insights from Global Sensitivity Analysis of a Functional-Structural Plant Model.

Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation (2023)
Journal Article
Rutjens, R. J. L., Band, L. R., Jones, M. D., & Owen, M. R. (2023). Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation. PLoS ONE, 18(10), e0293344. https://doi.org/10.1371/journal.pone.0293344

The Elementary Effects method is a global sensitivity analysis approach for identifying (un)important parameters in a model. However, it has almost exclusively been used where inputs are dimensionless and take values on [0, 1]. Here, we consider mode... Read More about Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation.

Modelling how plant cell-cycle progression leads to cell size regulation (2023)
Journal Article
Williamson, D., Tasker-Brown, W., Murray, J. A. H., Jones, A. R., & Band, L. R. (2023). Modelling how plant cell-cycle progression leads to cell size regulation. PLoS Computational Biology, 19(10), e1011503. https://doi.org/10.1371/journal.pcbi.1011503

Populations of cells typically maintain a consistent size, despite cell division rarely being precisely symmetrical. Therefore, cells must possess a mechanism of “size control”, whereby the cell volume at birth affects cell-cycle progression. While s... Read More about Modelling how plant cell-cycle progression leads to cell size regulation.

Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport (2023)
Journal Article
Kiradjiev, K. B., & Band, L. R. (2023). Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport. Bulletin of Mathematical Biology, 85, 101. https://doi.org/10.1007/s11538-023-01199-4

Determining how cell-scale processes lead to tissue-scale patterns is key to understanding how hormones and morphogens are distributed within biological tissues and control developmental processes. In this article, we use multiscale asymptotic analys... Read More about Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport.

Gibberellin and abscisic acid transporters facilitate endodermal suberin formation in Arabidopsis (2023)
Journal Article
Binenbaum, J., Wulff, N., Camut, L., Kiradjiev, K., Anfang, M., Tal, I., Vasuki, H., Zhang, Y., Sakvarelidze-Achard, L., Davière, J. M., Ripper, D., Carrera, E., Manasherova, E., Ben Yaakov, S., Lazary, S., Hua, C., Novak, V., Crocoll, C., Weinstain, R., …Shani, E. (2023). Gibberellin and abscisic acid transporters facilitate endodermal suberin formation in Arabidopsis. Nature Plants, 9, 785-802. https://doi.org/10.1038/s41477-023-01391-3

The plant hormone gibberellin (GA) regulates multiple developmental processes. It accumulates in the root elongating endodermis, but how it moves into this cell file and the significance of this accumulation are unclear. Here we identify three NITRAT... Read More about Gibberellin and abscisic acid transporters facilitate endodermal suberin formation in Arabidopsis.

Long-distance hormone transport via the phloem (2023)
Journal Article
Collis, H. L., Owen, M. R., & Band, L. R. (2023). Long-distance hormone transport via the phloem. Journal of Theoretical Biology, 562, 111415. https://doi.org/10.1016/j.jtbi.2023.111415

Several key plant hormones are synthesised in the shoot and are advected within the phloem to the root tip. In the root tip, these hormones regulate growth and developmental processes, and responses to environmental cues. However, we lack understandi... Read More about Long-distance hormone transport via the phloem.

In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought (2022)
Journal Article
Schäfer, E. D., Ajmera, I., Farcot, E., Owen, M. R., Band, L. R., & Lynch, J. P. (2022). In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought. Frontiers in Plant Science, 13, 1010165. https://doi.org/10.3389/fpls.2022.1010165

Drought is a primary constraint to crop yields and climate change is expected to increase the frequency and severity of drought stress in the future. It has been hypothesized that crops can be made more resistant to drought and better able to sequest... Read More about In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought.

Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models (2022)
Journal Article
Whittaker, D. G., Herrera-Reyes, A. D., Hendrix, M., Owen, M. R., Band, L. R., Mirams, G. R., Bolton, K. J., & Preston, S. P. (2023). Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models. Journal of Theoretical Biology, 558, 111337. https://doi.org/10.1016/j.jtbi.2022.111337

During the SARS-CoV2 pandemic, epidemic models have been central to policy-making. Public health responses have been shaped by model-based projections and inferences, especially related to the impact of various non-pharmaceutical interventions. Accom... Read More about Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models.

Modeling root loss reveals impacts on nutrient uptake and crop development (2022)
Journal Article
Schäfer, E. D., Owen, M. R., Band, L. R., Farcot, E., Bennett, M. J., & Lynch, J. P. (2022). Modeling root loss reveals impacts on nutrient uptake and crop development. Plant Physiology, 190(4), 2260-2278. https://doi.org/10.1093/plphys/kiac405

Abstract Despite the widespread prevalence of root loss in plants, its effects on crop productivity are not fully understood. While root loss reduces the capacity of plants to take up water and nutrients from the soil, it may provide benefits by decr... Read More about Modeling root loss reveals impacts on nutrient uptake and crop development.

Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold (2022)
Journal Article
Band, L. R., Nelissen, H., Preston, S. P., Rymen, B., Prinsen, E., Abd Elgawad, H., & Beemster, G. T. S. (2022). Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold. Proceedings of the National Academy of Sciences, 119(31), e2121288119. https://doi.org/10.1073/pnas.2121288119

The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of... Read More about Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold.

Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux (2022)
Journal Article
Mellor, N. L., Voß, U., Ware, A., Janes, G., Barrack, D., Bishopp, A., Bennett, M. J., Geisler, M., Wells, D. M., & Band, L. R. (2022). Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux. Plant Cell, 34(6), 2309–2327. https://doi.org/10.1093/plcell/koac086

Members of the B family of membrane-bound ATP-binding cassette (ABC) transporters represent key components of the auxin-efflux machinery in plants. Over the last two decades experimental studies have shown that modifying ABCB expression affects auxin... Read More about Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux.

Integrated root phenotypes for improved rice performance under low nitrogen availability (2022)
Journal Article
Ajmera, I., Henry, A., Radanielson, A. M., Klein, S. P., Ianevski, A., Bennett, M. J., Band, L. R., & Lynch, J. P. (2022). Integrated root phenotypes for improved rice performance under low nitrogen availability. Plant, Cell and Environment, 45(3), 805-822. https://doi.org/10.1111/pce.14284

Greater nitrogen efficiency would substantially reduce the economic, energy and environmental costs of rice production. We hypothesized that synergistic balancing of the costs and benefits for soil exploration among root architectural phenes is benef... Read More about Integrated root phenotypes for improved rice performance under low nitrogen availability.

Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots (2021)
Journal Article
Rizza, A., Tang, B., Stanley, C. E., Grossmann, G., Owen, M. R., Jones, A. M., & Band, L. R. (2021). Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots. Proceedings of the National Academy of Sciences, 118(8), e1921960118. https://doi.org/10.1073/pnas.1921960118

Control over cell growth by mobile regulators underlies much of eukaryotic morphogenesis. In plant roots, cell division and elongation are separated into distinct longitudinal zones and both division and elongation are influenced by the growth regula... Read More about Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots.

Roots or Flowers? Take a Guess (2020)
Book Chapter
Ajmera, I., Stekel, D., Band, L., & Hodgman, C. (2020). Roots or Flowers? Take a Guess. In F. Matthäus, S. Matthäus, S. Harris, & T. Hillen (Eds.), The Art of Theoretical Biology (pp. 66-67). Springer. https://link.springer.com/chapter/10.1007/978-3-030-33471-0_33

Phosphorus is a growth-limiting nutrient for plants. The use of phosphate (Pi) fertiliser is unsustainable because its stocks are non-renew-able and the run-off of surplus fertiliser damages the environment.

Auxin fluxes through plasmodesmata modify root-tip auxin distribution (2020)
Journal Article
Mellor, N. L., Voß, U., Janes, G., Bennett, M. J., Wells, D. M., & Band, L. R. (2020). Auxin fluxes through plasmodesmata modify root-tip auxin distribution. Development, 147(6), dev181669. https://doi.org/10.1242/dev.181669

© 2020. Published by The Company of Biologists Ltd. Auxin is a key signal regulating plant growth and development. It is well established that auxin dynamics depend on the spatial distribution of efflux and influx carriers on the cell membranes. In t... Read More about Auxin fluxes through plasmodesmata modify root-tip auxin distribution.

Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway (2018)
Journal Article
Band, L. R., & Preston, S. P. (2018). Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway. Journal of Theoretical Biology, 457, 66-78. https://doi.org/10.1016/j.jtbi.2018.05.028

Developing effective strategies to use models in conjunction with experimental data is essential to understand the dynamics of biological regulatory networks. In this study, we demonstrate how combining parameter estimation with asymptotic analysis c... Read More about Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway.