All Outputs (5)

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing (2022)
Journal Article
Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., …Ghaemmaghami, A. M. (2022). Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials, Article 2208364. https://doi.org/10.1002/adma.202208364

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involv... Read More about Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
Journal Article
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., …Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons (2018)
Journal Article
Geiszler, P. C., Ugun-Klusek, A., Lawler, K., Pardon, M., Yuchun, D., Bai, L., …Bedford, L. (in press). Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific Reports, 8, Article 4833. https://doi.org/10.1038/s41598-018-23155-2

Metabolite profiling is an important tool that may better capture the multiple features of neurodegeneration. With the considerable parallels between mouse and human metabolism, the use of metabolomics in mouse models with neurodegenerative pathology... Read More about Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway (2017)
Journal Article
Ugun-Klusek, A., Tatham, M. H., Elkharaz, J., Constantin-Teodosiu, D., Lawler, K., Mohamed, H., …Bedford, L. (2017). Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death and Disease, 8(1), e2531-e2531. https://doi.org/10.1038/cddis.2016.443

The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS an... Read More about Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event
Journal Article
Kay, C. J., Lawler, K., & Kerr, I. D. Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event. Bioscience Reports, 33(6), Article e00084. https://doi.org/10.1042/BSR20130049

As free-living organisms the ancestors of mitochondria and plastids encoded complete genomes, proteomes and metabolomes. As these symbionts became organelles all these aspects were reduced – genomes have degenerated with the host nucleus now encoding... Read More about Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event.