All Outputs (49)

Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting (2023)
Journal Article
Lee, A., Liang, L., Connerton, P. L., Connerton, I. F., & Mellits, K. H. (2023). Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting. Frontiers in Veterinary Science, 10, Article 1118302. https://doi.org/10.3389/fvets.2023.1118302

Introduction: Rotavirus A is a major cause of acute dehydrating diarrhea in neonatal pigs resulting in significant mortality, morbidity, reduced performance and economic loss. Commercially available prebiotic galacto-oligosaccharides are similar to t... Read More about Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting.

Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance (2022)
Journal Article
Lee, A., Le Bon, M., Connerton, I. F., & Mellits, K. H. (2022). Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance. FEMS Microbiology Ecology, 98(5), Article fiac048. https://doi.org/10.1093/femsec/fiac048

The primary objective of this study was to investigate if common colonic community indicators could be identified from the microbiota of 22-day-old suckling pigs in repeated small-scale trials. A total of three separate trials were conducted at diffe... Read More about Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance.

Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator (2021)
Journal Article
Saeedi, A., Cummings, N. J., McLean, D., Connerton, I. F., & Connerton, P. L. (2021). Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator. Scientific Reports, 11, Article 21393. https://doi.org/10.1038/s41598-021-00865-8

A novel Gram-stain negative, aerobic, halotolerant, motile, rod-shaped, predatory bacterium ASxL5T, was isolated from a bovine slurry tank in Nottinghamshire, UK using Campylobacter hyointestinalis as prey. Other Campylobacter species and members of... Read More about Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator.

Bacteriophage therapy to reduce colonization of campylobacter jejuni in broiler chickens before slaughter (2021)
Journal Article
D’angelantonio, D., Scattolini, S., Boni, A., Neri, D., Di Serafino, G., Connerton, P., …Aprea, G. (2021). Bacteriophage therapy to reduce colonization of campylobacter jejuni in broiler chickens before slaughter. Viruses, 13(8), Article 1428. https://doi.org/10.3390/v13081428

Campylobacteriosis is the most commonly reported gastrointestinal disease in humans. Campybacter jejuni is the main cause of the infection, and bacterial colonization in broiler chickens is widespread and difficult to prevent, leading to high risk of... Read More about Bacteriophage therapy to reduce colonization of campylobacter jejuni in broiler chickens before slaughter.

Acetate and auto-inducing peptide are independent triggers of quorum sensing in Lactobacillus plantarum (2021)
Journal Article
Meng, F., Lu, F., Du, H., Nie, T., Zhu, X., Connerton, I. F., …Lu, Y. (2021). Acetate and auto-inducing peptide are independent triggers of quorum sensing in Lactobacillus plantarum. Molecular Microbiology, 116(1), 298-310. https://doi.org/10.1111/mmi.14709

The synthesis of plantaricin in Lactobacillus plantarum is regulated by quorum sensing. However, the nature of the extra-cytoplasmic (EC) sensing domain of the histidine kinase (PlnB1) and the ability to recognize the auto-inducing peptide PlnA1 is n... Read More about Acetate and auto-inducing peptide are independent triggers of quorum sensing in Lactobacillus plantarum.

Bacteriophages to control multi-drug resistant enterococcus faecalis infection of dental root canals (2021)
Journal Article
El-Telbany, M., El-Didamony, G., Askora, A., Ariny, E., Abdallah, D., Connerton, I. F., & El-Shibiny, A. (2021). Bacteriophages to control multi-drug resistant enterococcus faecalis infection of dental root canals. Microorganisms, 9(3), Article 517. https://doi.org/10.3390/microorganisms9030517

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Phage therapy is an alternative treatment to antibiotics that can overcome multi-drug resistant bacteria. In this study, we aimed to isolate and characterize lytic bacteriophages targeted agai... Read More about Bacteriophages to control multi-drug resistant enterococcus faecalis infection of dental root canals.

Food biotechnology (2020)
Journal Article
Foster, T., Adams, G., di Bari, V., Connerton, I., Gould, J., Gouseti, O., …Yakubov, G. (2020). Food biotechnology. Current Opinion in Chemical Engineering, 30, 53-59. https://doi.org/10.1016/j.coche.2020.08.006

We investigate recent advances in the Chemical Engineering aspects of food structuring agents and macronutrients: carbohydrates, proteins and lipids, and also the fate of food upon ingestion. Prebiotic effects on host-microbe interactions enable impr... Read More about Food biotechnology.

Campylobacter bacteriophage DA10: An excised temperate bacteriophage targeted by CRISPR-cas (2020)
Journal Article
Hooton, S., D’Angelantonio, D., Hu, Y., Connerton, P. L., Aprea, G., & Connerton, I. F. (2020). Campylobacter bacteriophage DA10: An excised temperate bacteriophage targeted by CRISPR-cas. BMC Genomics, 21(1), Article 400. https://doi.org/10.1186/s12864-020-06808-3

Background: Lytic bacteriophages that infect Campylobacter spp. have been utilized to develop therapeutic/decontamination techniques. However, the association of Campylobacter spp. and bacteriophages has been the focus of several strands of research... Read More about Campylobacter bacteriophage DA10: An excised temperate bacteriophage targeted by CRISPR-cas.

Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia (2020)
Journal Article
Chinivasagam, H. N., Estella, W., Maddock, L., Mayer, D. G., Weyand, C., Connerton, P. L., & Connerton, I. F. (2020). Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.00632

© Copyright © 2020 The State of Queensland (through the Department Agriculture and Fisheries). This study describes the development and use of bacteriophage cocktails to control Campylobacter in broiler chickens, in a commercial setting, in Queenslan... Read More about Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia.

Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy (2020)
Journal Article
Mohamed, A., Taha, O., El-Sherif, H. M., Connerton, P. L., Hooton, S. P., Bassim, N. D., …El-Shibiny, A. (2020). Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy. Viruses, 12(4), 1-20. https://doi.org/10.3390/v12040424

© 2020 by the authors. Developing novel antimicrobials capable of controlling multidrug-resistant bacterial pathogens is essential to restrict the use of antibiotics. Bacteriophages (phages) constitute a major resource that can be harnessed as an alt... Read More about Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy.

Application of a novel phage LPSEYT for biological control of Salmonella in foods (2020)
Journal Article
Yan, T., Liang, L., Yin, P., Zhou, Y., Sharoba, A. M., Lu, Q., …Li, J. (2020). Application of a novel phage LPSEYT for biological control of Salmonella in foods. Microorganisms, 8(3), Article 400. https://doi.org/10.3390/microorganisms8030400

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella is a leading cause of foodborne diseases, and in recent years, many isolates have exhibited a high level of antibiotic resistance, which has led to huge pressures on public health.... Read More about Application of a novel phage LPSEYT for biological control of Salmonella in foods.

Development of a lyophilization process for Campylobacter bacteriophage storage and transport (2020)
Journal Article
Liang, L., Carrigy, N. B., Kariuki, S., Muturi, P., Onsare, R., Nagel, T., …Connerton, I. F. (2020). Development of a lyophilization process for Campylobacter bacteriophage storage and transport. Microorganisms, 8(2), 1-13. https://doi.org/10.3390/microorganisms8020282

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stabili... Read More about Development of a lyophilization process for Campylobacter bacteriophage storage and transport.

Application of a broad range lytic phage LPST94 for biological control of salmonella in foods (2020)
Journal Article
Islam, M. S., Zhou, Y., Liang, L., Nime, I., Yan, T., Willias, S. P., …Li, J. (2020). Application of a broad range lytic phage LPST94 for biological control of salmonella in foods. Microorganisms, 8(2), Article 247. https://doi.org/10.3390/microorganisms8020247

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella, one of the most common food-borne pathogens, is a significant public health and economic burden worldwide. Lytic phages are viable alternatives to conventional technologies for pat... Read More about Application of a broad range lytic phage LPST94 for biological control of salmonella in foods.

Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens (2020)
Journal Article
Flaujac Lafontaine, G. M., Connerton, I. F., Richards, P. J., Fish, N. M., Connerton, P. L., Cummings, N. J., …Connerton, I. F. (2020). Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.03030

© Copyright © 2020 Flaujac Lafontaine, Richards, Connerton, O’Kane, Ghaffar, Cummings, Fish and Connerton. Worldwide Campylobacter jejuni is a leading cause of foodborne disease. Contamination of chicken meat with digesta from C. jejuni-positive bird... Read More about Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens.

Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance (2020)
Journal Article
Connerton, I. F., Richards, P. J., Fish, N. M., Flaujac Lafontaine, G. M., Asiani, K., Connerton, P. L., …Richards, P. J. (2020). Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance. mSystems, 5(1), Article e00827-19. https://doi.org/10.1128/msystems.00827-19

Copyright © 2020 Richards et al Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens... Read More about Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance.

Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot (2020)
Journal Article
Hobley, L., Summers, J. K., Till, R., Milner, D. S., Atterbury, R. J., Stroud, A., …Sockett, R. E. (2020). Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot. Journal of Bacteriology, 202(6), Article e00629-19. https://doi.org/10.1128/JB.00629-19

Copyright © 2020 Hobley et al. Bacteria are preyed upon by diverse microbial predators, including bacteriophage and predatory bacteria, such as Bdellovibrio bacteriovorus. While bacteriophage are used as antimicrobial therapies in Eastern Europe and... Read More about Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot.

Resistance mechanisms adopted by a Salmonella Typhimurium mutant against bacteriophage (2019)
Journal Article
Wang, C., Nie, T., Lin, F., Connerton, I. F., Lu, Z., Zhou, S., & Hang, H. (2019). Resistance mechanisms adopted by a Salmonella Typhimurium mutant against bacteriophage. Virus Research, 273, Article 197759. https://doi.org/10.1016/j.virusres.2019.197759

© 2019 Elsevier B.V. Bacteriophages have key roles in regulating bacterial populations in most habitats. A Salmonella Typhimurium mutant (N18) with impaired sensitivity to phage fmb-p1 was obtained and examined, the adsorption efficiency of fmb-p1 to... Read More about Resistance mechanisms adopted by a Salmonella Typhimurium mutant against bacteriophage.

Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure (2019)
Journal Article
Carrigy, N. B., Liang, L., Wang, H., Kariukic, S., Nagel, T. E. .., Connerton, I. F., & Vehringa, R. (2019). Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure. International Journal of Pharmaceutics, 569, https://doi.org/10.1016/j.ijpharm.2019.118601

Campylobacter jejuni is a leading cause of foodborne illness globally. In this study, a spray drying and packaging process was developed to produce a thermally-stable dry powder containing bacteriophages that retains biological activity against C. je... Read More about Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure.

Encapsulation of E. coli phage ZCEC5 in chitosan-alginate beads as a delivery system in phage therapy (2019)
Journal Article
Abdelsattar, A. S., Abdelrahmen, F., Dawoud, A., Connerton, I. F., & El-Shibiny, A. (2019). Encapsulation of E. coli phage ZCEC5 in chitosan-alginate beads as a delivery system in phage therapy. Applied Microbiology and Biotechnology, 9, Article 87. https://doi.org/10.1186/s13568-019-0810-9

© 2019, The Author(s). Bacteriophages can be used successfully to treat pathogenic bacteria in the food chain including zoonotic pathogens that colonize the intestines of farm animals. However, harsh gastric conditions of low pH and digestive enzyme... Read More about Encapsulation of E. coli phage ZCEC5 in chitosan-alginate beads as a delivery system in phage therapy.

Understanding “corruption” in regulatory agencies: The case of food inspection in Saudi Arabia (2019)
Journal Article
Al-Mutairi, S., Connerton, I., & Dingwall, R. (2019). Understanding “corruption” in regulatory agencies: The case of food inspection in Saudi Arabia. Regulation and Governance, 13(4), 507-519. https://doi.org/10.1111/rego.12247

Corruption is a relatively neglected topic in studies of regulatory agencies. The label is applied to a wide range of deviations from behavioral standards ultimately derived from Weber's account of the ideals of Prussian bureaucracy. This paper draws... Read More about Understanding “corruption” in regulatory agencies: The case of food inspection in Saudi Arabia.