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All Outputs (38)

The ‘barcode sign’ seen on optical coherence tomography of extensive corneal vascularization (2023)
Journal Article
El Zawahry, F. O., Beer, F., Yildiz, B. K., Said, D. G., & Dua, H. S. (2023). The ‘barcode sign’ seen on optical coherence tomography of extensive corneal vascularization. Eye, 37, 3863-3864. https://doi.org/10.1038/s41433-023-02602-z

Optical Coherence Tomography (OCT) is used extensively in imaging the cornea in health and disease. OCT delineates interfaces of differing refractive indices, which often but not always correspond to histological features of the tissue. Interpretatio... Read More about The ‘barcode sign’ seen on optical coherence tomography of extensive corneal vascularization.

The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controversy (2023)
Journal Article
Dua, H. S., Freitas, R., Mohammed, I., Ting, D. S., & Said, D. G. (2023). The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controversy. Progress in Retinal and Eye Research, 97, Article 101161. https://doi.org/10.1016/j.preteyeres.2022.101161

The pre-Descemet's layer/Dua's layer, also termed the Dua-Fine layer and the pre-posterior limiting lamina layer, lies anterior to the Descemet's membrane in the cornea, is 10 μ m (range 6-16) thick, made predominantly of type I and some type VI coll... Read More about The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controversy.

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article
Ali, W., Elsahn, A., Ting, D. S. J., Dua, H. S., & Mohammed, I. (2022). Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic. Antibiotics, 11(4), Article 475. https://doi.org/10.3390/antibiotics11040475

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study (2021)
Journal Article
Ting, D. S. J., Galal, M., Kulkarni, B., Elalfy, M. S., Lake, D., Hamada, S., …Dua, H. S. (2021). Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study. Journal of Fungi, 7(11), Article 966. https://doi.org/10.3390/jof7110966

Fungal keratitis (FK) is a serious ocular infection that often poses significant diagnostic and therapeutic dilemmas. This study aimed to examine the causes, clinical characteristics, out-comes, and prognostic factors of FK in the UK. All culture-pos... Read More about Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes (2021)
Journal Article
Song, A., Deshmukh, R., Lin, H., Ang, M., Mehta, J. S., Chodosh, J., …Ting, D. S. (2021). Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes. Frontiers in Medicine, 8, Article 707242. https://doi.org/10.3389/fmed.2021.707242

Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less common... Read More about Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance (2021)
Journal Article
Ting, D. S. J., Ho, C. S., Deshmukh, R., Said, D. G., & Dua, H. S. (2021). Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye, 35, 1084-1101. https://doi.org/10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing... Read More about Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study (2020)
Journal Article
Ting, D. S. J., Ho, C. S., Cairns, J., Gopal, B. P., Elsahn, A., Al-Aqaba, M., …Dua, H. S. (2021). Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study. Eye, 35(9), 2543-2549. https://doi.org/10.1038/s41433-020-01272-5

Purpose: The purpose of this study is to examine the seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis (IK) in Nottingham, UK. Methods: A retrospective study of all patients who were diagnosed wi... Read More about Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis (2020)
Journal Article
Mohammed, I., Mohanty, D., Said, D. G., Barik, M. R., Reddy, M. M., Alsaadi, A., …Mittal, R. (2021). Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. British Journal of Ophthalmology, 105(8), 1172-1177. https://doi.org/10.1136/bjophthalmol-2020-316329

Background Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infectio... Read More about Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.

Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin) (2019)
Journal Article
Ghoz, N., Britton, J., Ross, A. R., Mohammed, I., Hogan, E., Said, D. G., & Dua, H. S. (2019). Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin). Eye, 33(11), 1776-1783. https://doi.org/10.1038/s41433-019-0493-0

Background

To assess the efficacy of combined 5FU and Avastin injections in the treatment of primary pterygium

Methods

Sixteen eyes with primary pterygium received intralesional 5 fluorouracil and Avastin (2.5–5 mg) injections every 2 weeks... Read More about Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy (2018)
Journal Article
Mastropasqua, L., Nubile, M., Lanzini, M., Calienno, R., & Dua, H. S. (2019). In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. Journal of Cellular Physiology, 234(5), 6108-6115. https://doi.org/10.1002/jcp.27345

© 2018 Wiley Periodicals, Inc. Neurotrophic keratopathy (NK) is a rare degenerative corneal disorder characterized by instability of epithelial integrity with consequent epithelial defects that can worsen up to persistent epithelial defects with stro... Read More about In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy.

Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study (2018)
Journal Article
Wilde, C., Awad, M., Dua, H., Gandhewar, R., Chen, H., & Amoaku, W. M. (2018). Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study. Ophthalmology Retina, 2(12), 1218-1226. https://doi.org/10.1016/j.oret.2018.06.009

© 2018 Purpose: To evaluate outcomes of epiretinal membrane (ERM) surgery in eyes with subretinal drusenoid deposits (SRDDs) and to compare them with those with isolated ERM. Design: Retrospective case-control study of consecutive patients who underw... Read More about Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study.

Healing of autologous conjunctival grafts in pterygium surgery (2018)
Journal Article
Ghoz, N., Elalfy, M., Said, D., & Dua, H. (2018). Healing of autologous conjunctival grafts in pterygium surgery. Acta Ophthalmologica, 96(8), e979-e988. https://doi.org/10.1111/aos.13794

Purpose
To temporally study the healing of conjunctival autografts in consecutive patients following pterygium surgery.

Methods
A case‐cohort observational study. Thirty‐two eyes of 28 patients who underwent pterygium surgery were included. All... Read More about Healing of autologous conjunctival grafts in pterygium surgery.

Lamellar keratoplasty techniques (2018)
Journal Article
Singh, N. P., Said, D. G., & Dua, H. S. (2018). Lamellar keratoplasty techniques. Indian Journal of Ophthalmology, 66(9), 1239-1250. https://doi.org/10.4103/ijo.IJO_95_18

© 2018 Indian Journal of Ophthalmology. Lamellar keratoplasty (LK) has revolutionized corneal graft surgery in several ways. Deep anterior LK (DALK) has eliminated risk of failure due to endothelial rejection. Endothelial keratoplasty (EK) has almost... Read More about Lamellar keratoplasty techniques.

Neurotrophic keratopathy (2018)
Journal Article
Dua, H. S., Said, D. G., Messmer, E. M., Rolando, M., Benitez-del-Castillo, J. M., Hossain, P. N., …Baudouin, C. (2018). Neurotrophic keratopathy. Progress in Retinal and Eye Research, 66, 107-131. https://doi.org/10.1016/j.preteyeres.2018.04.003

Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor... Read More about Neurotrophic keratopathy.

Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different (2018)
Journal Article
Ross, A. R., Said, D. G., El-Amin, A., Altaan, S., Cabrerizo, J., Nubile, M., …Dua, H. S. (2018). Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different. British Journal of Ophthalmology, 102(12), 1646-1652. https://doi.org/10.1136/bjophthalmol-2017-311349

Aims: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty.

Methods: Intrastromal injections of 0.1 and 0.3 mL of sodium hyaluronate 1.2% and 0.6% were made into sclera... Read More about Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different.