Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe
(2002)
Journal Article
Atkinson, G. E., Cowan, A., McInnes, C., Zheleva, D. I., Fischer, P. M., & Chan, W. C. (2002). Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe. Bioorganic and Medicinal Chemistry Letters, 12(18), 2501-2505. https://doi.org/10.1016/S0960-894X%2802%2900508-5
A focused series of octapeptides based on the lead compound H-His-Ala-Lys-Arg-Arg-Leu-Ile-Phe-NH2 1, in which the C-terminal phenylalanine residue was replaced by α and/or β-modified variants, was synthesized using solid-phase chemistry. Both the L-t... Read More about Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe.