All Outputs (11)

Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana (2021)
Journal Article
Behnke, J. M., Stewart, A., Smales, L., Cooper, G., Lowe, A., Kinsella, J. M., …Webster, J. P. (2022). Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana. Parasitology, 149(1), 76-94. https://doi.org/10.1017/S0031182021001578

Oxyurid nematodes (Syphacia spp.) from bank (Myodes glareolus) and field/common (Microtus spp.) voles, from disparate geographical sites in the British Isles, were examined morphologically and genetically. The genetic signatures of 118 new isolates a... Read More about Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana.

Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus (2019)
Journal Article
Taylor, C. H., Young, S., Fenn, J., Lamb, A. L., Lowe, A. E., Poulin, B., …Bradley, J. E. (2019). Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus. Functional Ecology, 33(8), 1425-1435. https://doi.org/10.1111/1365-2435.13354

1. The ability, propensity and need to mount an immune response vary both among individuals and within a single individual over time. 2. A wide array of parameters have been found to influence immune state in carefully controlled experiments, but... Read More about Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus.

Physiological, but not fitness, effects of two interacting haemoparasitic infections in a wild rodent (2018)
Journal Article
Taylor, C. H., Wanelik, K. M., Friberg, I. M., Lowe, A., Hall, A. J., Ralli, C., …Bradley, J. E. (2018). Physiological, but not fitness, effects of two interacting haemoparasitic infections in a wild rodent. International Journal for Parasitology, 48(6), 463-471. https://doi.org/10.1016/j.ijpara.2017.11.006

In contrast to the conditions in most laboratory studies, wild animals are routinely challenged by multiple infections at once, and these infections can interact in complex ways. This means that the impact of a parasite on its host’s physiology and f... Read More about Physiological, but not fitness, effects of two interacting haemoparasitic infections in a wild rodent.

An Immunological Marker of Tolerance to Infection in Wild Rodents (2014)
Journal Article
Jackson, J. A., Hall, A. J., Friberg, I. M., Ralli, C., Lowe, A., Zawadzka, M., …Begon, M. (2014). An Immunological Marker of Tolerance to Infection in Wild Rodents. PLoS Biology, 12(7), Article e1001901. https://doi.org/10.1371/journal.pbio.1001901

Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, w... Read More about An Immunological Marker of Tolerance to Infection in Wild Rodents.

Developing novel anthelmintics from plant cysteine proteinases (2008)
Journal Article
Behnke, J. M., Buttle, D. J., Stepek, G., Lowe, A., & Duce, I. (2008). Developing novel anthelmintics from plant cysteine proteinases. Parasites and Vectors, 1(29), https://doi.org/10.1186/1756-3305-1-29

Intestinal helminth infections of livestock and humans are predominantly controlled by treatment with three classes of synthetic drugs, but some livestock nematodes have now developed resistance to all three classes and there are signs that human hoo... Read More about Developing novel anthelmintics from plant cysteine proteinases.

In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents (2007)
Journal Article
Stepek, G., Lowe, A. E., Buttle, D. J., Duce, I. R., & Behnke, J. M. (2007). In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents. Journal of Helminthology, 81(4), https://doi.org/10.1017/S0022149X0786408X

Infections with gastrointestinal (GI) nematodes are amongst the most prevalent worldwide, especially in tropical climates. Control of these infections is primarily through treatment with anthelmintic drugs, but the rapid development of resistance to... Read More about In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents.

The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo (2007)
Journal Article
Stepek, G., Lowe, A., Buttle, D. J., Duce, I., & Behnke, J. M. (2007). The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo. Parasitology, 134(10), https://doi.org/10.1017/S0031182007002867

Gastrointestinal (GI) nematodes are important disease-causing organisms, controlled primarily through treatment with synthetic drugs, but the efficacy of these drugs has declined due to widespread resistance, and hence new drugs, with different modes... Read More about The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo.

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo (2007)
Journal Article
Stepek, G., Lowe, A., Buttle, D. J., Duce, I., & Behnke, J. M. (2007). Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo. Parasitology, 134(1), https://doi.org/10.1017/S0031182006001302

Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, Heligmosomoides polygyrus (which is found... Read More about Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo.

Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes (2007)
Journal Article
Stepek, G., Curtis, R., Kerry, B., Shewry, P., Clark, S., Lowe, A., …Behnke, J. (2007). Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes. Parasitology, 134(12), https://doi.org/10.1017/S0031182007003289

Cysteine proteinases from the fruit and latex of plants, such as papaya, pineapple and fig, have previously been shown to have substantial anthelmintic efficacy, in vitro and in vivo, against a range of animal parasitic nematodes. In this paper, we d... Read More about Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes.

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris (2006)
Journal Article
Stepek, G., Lowe, A., Buttle, D. J., Duce, I., & Behnke, J. M. (2006). In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris. Parasitology, 132(5), https://doi.org/10.1017/S003118200500973X

Extracts of plants, such as papaya, pineapple and fig, are known to be effective at killing intestinal nematodes that inhabit anterior sites in the small intestine, such as Heligmosomoides polygyrus. In this paper, we demonstrate that similar in vitr... Read More about In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris.

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro (2005)
Journal Article
Stepek, G., Buttle, D. J., Duce, I., Lowe, A., & Behnke, J. M. (2005). Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro. Parasitology, 130(2), https://doi.org/10.1017/S0031182004006225

We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig, kiwi fruit and Egyptian milkweed in vitro using the rodent gastrointestinal nematode Heligmosomoides polygyrus. Within a 2... Read More about Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.