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Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? (2016)
Journal Article
Steenblock, C., de Celis, M. F. R., Androutsellis-Theotokis, A., Sue, M., Delgadillo Silva, L. F., Eisenhofer, G., …Bornstein, S. R. (2017). Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?. Molecular and Cellular Endocrinology, 441, https://doi.org/10.1016/j.mce.2016.09.011

The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and charac... Read More about Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?.

Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination (2016)
Journal Article
Toutouna, L., Nikolakopoulou, P., Poser, S. W., Masjkur, J., Arps-Forker, C., Troullinaki, M., …Androutsellis-Theotokis, A. (2016). Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination. Brain Research, 1642, https://doi.org/10.1016/j.brainres.2016.03.014

Hes3 is a component of the STAT3-Ser/Hes3 Signaling Axis controlling the growth and survival of neural stem cells and other plastic cells. Pharmacological activation of this pathway promotes neuronal rescue and behavioral recovery in models of ischem... Read More about Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.

Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology (2016)
Journal Article
Masjkur, J., Poser, S. W., Nikolakopoulou, P., Chrousos, G., McKay, R. D., Bornstein, S. R., …Androutsellis-Theotokis, A. (2016). Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology. Diabetes, 65(2), https://doi.org/10.2337/db15-1099

Loss of insulin-producing pancreatic islet β-cells is a hallmark of type 1 diabetes. Several experimental paradigms demonstrate that these cells can, in principle, be regenerated from multiple endogenous sources using signaling pathways that are also... Read More about Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology.

The effects of stress on brain and adrenal stem cells (2016)
Journal Article
de Celis, M. F. R., Bornstein, S. R., Androutsellis-Theotokis, A., Andoniadou, C. L., Licinio, J., Wong, M., & Ehrhart-Bornstein, M. (in press). The effects of stress on brain and adrenal stem cells. Molecular Psychiatry, 21(5), https://doi.org/10.1038/mp.2015.230

The brain and adrenal are critical control centers that maintain body homeostasis under basal and stress conditions, and orchestrate the body’s response to stress. It is noteworthy that patients with stress-related disorders exhibit increased vulnera... Read More about The effects of stress on brain and adrenal stem cells.

STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? (2016)
Journal Article
Nikolakopoulou, P., Poser, S., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C., …Androutsellis-Theotokis, A. (2016). STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?. Hormone and Metabolic Research, 48(2), https://doi.org/10.1055/s-0041-111699

The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of... Read More about STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?.

Concise review: Reprogramming, behind the scenes: noncanonical neural stem cell signaling pathways reveal new, unseen regulators of tissue plasticity with therapeutic implications (2015)
Journal Article
Poser, S. W., Chenoweth, J. G., Colantuoni, C., Masjkur, J., Chrousos, G., Bornstein, S. R., …Androutsellis-Theotokis, A. (2015). Concise review: Reprogramming, behind the scenes: noncanonical neural stem cell signaling pathways reveal new, unseen regulators of tissue plasticity with therapeutic implications. STEM CELLS, 4(11), https://doi.org/10.5966/sctm.2015-0105

Interest is great in the new molecular concepts that explain, at the level of signal transduction, the process of reprogramming. Usually, transcription factors with developmental importance are used, but these approaches give limited information on t... Read More about Concise review: Reprogramming, behind the scenes: noncanonical neural stem cell signaling pathways reveal new, unseen regulators of tissue plasticity with therapeutic implications.

Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population (2015)
Journal Article
Vukicevic, V., Rubin de Celis, M. F., Pellegata, N. S., Bornstein, S. R., Androutsellis-Theotokis, A., & Ehrhart-Bornstein, M. (2015). Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population. Molecular and Cellular Endocrinology, 408, https://doi.org/10.1016/j.mce.2014.12.020

The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues... Read More about Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population.

Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration (2014)
Journal Article
Poser, S. W., & Androutsellis-Theotokis, A. (2014). Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration. Diabetes, 5(6), https://doi.org/10.1186/scrt517

There is a growing interest in the therapeutic utility of compounds derived from Curcuma longa, an herb of the Zingiberaceae family that has been part of traditional medicine for centuries. Recent reports suggest that bioactive compounds isolated fro... Read More about Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration.

Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release (2014)
Journal Article
Masjkur, J., Arps-Forker, C., Poser, S. W., Nikolakopoulou, P., Toutouna, L., Chenna, R., …Androutsellis-Theotokis, A. (2014). Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. Journal of Biological Chemistry, 289(51), https://doi.org/10.1074/jbc.M114.590687

The transcription factor Hes3 is a component of a signaling pathway that supports the growth of neural stem cells with profound consequences in neurodegenerative disease models. Here we explored whether Hes3 also regulates pancreatic islet cells. We... Read More about Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation (2014)
Journal Article
Chatzigeorgiou, A., Chung, K., Garcia-Martin, R., Alexaki, V., Klotzsche-von Ameln, A., Phieler, J., …Chavakis, T. (2014). Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology, 60(4), https://doi.org/10.1002/hep.27233

The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells... Read More about Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation.

Methods for assessing the regenerative responses of neural tissue (2014)
Book Chapter
Poser, S. W., Rueger, M. A., & Androutsellis-Theotokis, A. (2014). Methods for assessing the regenerative responses of neural tissue. In B. Christ, J. Oerlecke, & P. Stock (Eds.), Animal models for stem cell therapy (293-302). Humana Press. https://doi.org/10.1007/978-1-4939-1453-1_24

In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the co... Read More about Methods for assessing the regenerative responses of neural tissue.