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Left triangular ligament lesions are likely hepatic in origin: a systematic review (2023)
Journal Article
Agarwal, S., Munyal, R., Aravinthan, A. D., & Clarke, C. G. D. (2023). Left triangular ligament lesions are likely hepatic in origin: a systematic review. British Journal of Radiology, 96(1152), Article 20230231. https://doi.org/10.1259/bjr.20230231

Objectives: The left lobe of liver is connected to the left hemi-diaphragm by the left triangular ligament (LTL) which crosses the left upper quadrant (LUQ) of the abdomen. LTL lesions are rare and can cause diagnostic confusion. We encountered a hep... Read More about Left triangular ligament lesions are likely hepatic in origin: a systematic review.

Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study (2023)
Journal Article
Palaniyappan, N., Peach, E., Pearce, F., Dhaliwal, A., Campos-Varela, I., Cant, M. R., …Aravinthan, A. D. (2024). Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study. Liver Transplantation, 30(2), 170-181. https://doi.org/10.1097/LVT.0000000000000244

The long-term (>5y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospectively collect... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study.

Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study (2023)
Journal Article
Palaniyappan, N., Peach, E., Pearce, F., Dhaliwal, A., Campos-Varela, I., Cant, M. R., …Aravinthan, A. D. (2024). Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study. Liver Transplantation, 30(2), 170-181. https://doi.org/10.1097/LVT.0000000000000244

The long-term (>5 year) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicentre retrospective analysis of prospectively... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study.

Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance (2023)
Journal Article
Scott, R. A., Cross, T. J., Clarke, C., Khan, S. A., Ryder, S. D., Franklin, J., & Aravinthan, A. D. (2023). Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance. Journal of Hepatocellular Carcinoma, 10, 725-731. https://doi.org/10.2147/JHC.S403702

Background & Aim: HCC has significantly improved outcomes when detected early. Guidelines recommend biannual surveillance with ultrasound (US) and/or AFP in at-risk individuals. This survey aimed to describe HCC surveillance adherence/practices a... Read More about Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance.

Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy (2023)
Working Paper
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M. W., …Venkatachalapathy, S. V. Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy

Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. It is difficult to identify cysts with malignant potential. Diagnosis often relies on collection of c... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy.

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression (2022)
Journal Article
Wijayasiri, P., Astbury, S., Kaye, P., Oakley, F., Alexander, G. J., Kendall, T. J., & Aravinthan, A. D. (2022). Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression. Cells, 11(14), Article 2221. https://doi.org/10.3390/cells11142221

Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained fro... Read More about Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression.

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis (2022)
Journal Article
Subhani, M., Sheth, A., Ahmed, J., Wijayasiri, P., Gardezi, S. A., Enki, D., …Aravinthan, A. D. (2022). Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis. Thrombosis Research, 215, 19-29. https://doi.org/10.1016/j.thromres.2022.05.004

Background and Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles t... Read More about Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis.

Estimating the clinical prevalence of Wilson’s disease in the UK (2021)
Journal Article
Wijayasiri, P., Hayre, J., Nicholson, E. S., Kaye, P., Wilkes, E. A., Evans, J., …Aravinthan, A. D. (2021). Estimating the clinical prevalence of Wilson’s disease in the UK. JHEP Reports, 3(5), Article 100329. https://doi.org/10.1016/j.jhepr.2021.100329

Background and Aim The clinical prevalence of Wilson’s disease (WD) in the UK remains unknown. The estimated genetic prevalence in the UK, 142/million, is higher than the clinical prevalence (15/million) reported in other European studies. The aim o... Read More about Estimating the clinical prevalence of Wilson’s disease in the UK.

Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home (2021)
Journal Article
Tsien, C., Tan, H., Sharma, S., Palaniyappan, N., Wijayasiri, P., Leung, K., …Aravinthan, A. D. (2021). Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine, 21(1), e32-e38. https://doi.org/10.7861/clinmed.2020-0609

Introduction: Increasing rates of liver transplantation and improved outcomes have led to greater numbers of transplant recipients followed up in non-transplant centres. Our aim was to document long-term clinical outcomes of liver transplant recipien... Read More about Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home.

Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle (2020)
Journal Article
Wing Chow, C., Asma Haider, S., Ragunath, K., Aithal, G. P., James, M. W., Ortiz-Fernandez-Sordo, J., …Vasan Venkatachalapathy, S. (2020). Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle. World Journal of Gastrointestinal Endoscopy, 12(9), 266-275. https://doi.org/10.4253/wjge.v12.i9.266

BACKGROUND Reverse bevel (RB) needle is widely used for endoscopic ultrasound fine needle biopsy (EUS-FNB). A 3-plane symmetrical needle with Franseen geometry (FG) has recently become available. AIM To compare the clinical efficacy of FG to that... Read More about Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle.

Donor outcomes in anonymous live liver donation (2019)
Journal Article
Goldaracena, N., Jung, J., Aravinthan, A. D., Abbey, S. E., Krause, S., Pritlove, C., …Grant, D. (2019). Donor outcomes in anonymous live liver donation. Journal of Hepatology, 71(5), 951-959. https://doi.org/10.1016/j.jhep.2019.06.027

Background Death rates on liver transplant waiting lists range from 5%-25%. Herein, we report a unique experience with 50 anonymous persons who volunteered to address this gap by offering to donate part of their liver to a recipient with whom they h... Read More about Donor outcomes in anonymous live liver donation.

The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation (2019)
Journal Article
Aravinthan, A. D., Fateen, W., Doyle, A. C., Venkatachalapathy, S. V., Issachar, A., Galvin, Z., …Bhat, M. (2019). The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation. Transplantation, 103(12), 2523-2530. https://doi.org/10.1097/TP.0000000000002757

Background: Diabetes mellitus (DM) is said to adversely affect transplant outcomes. The aim of this study was to investigate the impact of pre-existing and post-transplant DM on liver transplant (LT) recipients. Method: A single centre retrospective... Read More about The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation.

Outcomes of Radiofrequency Ablation as First-Line Therapy for Hepatocellular Carcinoma less than 3 cm in Potentially Transplantable Patients (2019)
Journal Article
Doyle, A., Gorgen, A., Muaddi, H., Aravinthan, A. D., Issachar, A., Mironov, O., …Sapisochin, G. (2019). Outcomes of Radiofrequency Ablation as First-Line Therapy for Hepatocellular Carcinoma less than 3 cm in Potentially Transplantable Patients. Journal of Hepatology, 70(5), 866-873. https://doi.org/10.1016/j.jhep.2018.12.027

© 2019 European Association for the Study of the Liver Background & Aims: Radiofrequency ablation (RFA) is an effective treatment for single hepatocellular carcinoma (HCC) ≤3 cm. Disease recurrence is common, and in some patients will occur outside t... Read More about Outcomes of Radiofrequency Ablation as First-Line Therapy for Hepatocellular Carcinoma less than 3 cm in Potentially Transplantable Patients.

Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study (2017)
Journal Article
Aravinthan, A. D., Barbas, A. S., Doyle, A. C., Tazari, M., Sapisochin, G., Cattral, M. S., …Renner, E. L. (in press). Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study. Transplant International, https://doi.org/10.1111/tri.13008

Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven patients who we... Read More about Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study.

Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma (2017)
Journal Article
Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H., Goldaracena, N., Issachar, A., …Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), https://doi.org/10.1245/s10434-017-5789-3

Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a... Read More about Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma.

First-degree living-related donor liver transplantation in autoimmune liver diseases. (2016)
Journal Article
Aravinthan, A., Doyle, A., Issachar, A., Dib, M., Peretz, D., Cattral, M., …Renner, E. (2016). First-degree living-related donor liver transplantation in autoimmune liver diseases. American Journal of Transplantation, 16(12), 3512-3521. https://doi.org/10.1111/ajt.13828

Liver transplantation (LT) is the treatment of choice for end?stage autoimmune liver diseases. However, the underlying disease may recur in the graft in some 20% of cases. The aim of this study is to determine whether LT using living donor grafts fro... Read More about First-degree living-related donor liver transplantation in autoimmune liver diseases..

Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis (2015)
Journal Article
Tachtatzis, P. M., Marshall, A., Aravinthan, A., Verma, S., Penrhyn-Lowe, S., Mela, M., …Alexander, G. J. (2015). Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis. PLoS ONE, 10(5), 1-17. https://doi.org/10.1371/journal.pone.0127511

Background Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the effect of HBV on hepatocy... Read More about Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis.