Research Repository

See what's under the surface

Browse


System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire
Book Chapter
Figueredo, G. P., Aickelin, U., & Whitbrook, A. System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire. In Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UKIntelligent Modelling & Analysis (IMA)

The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immuno-degradation that indicate signs of functionality loss possibly leading to death. Even though it is not po... Read More

Role of NADH Dehydrogenase (Ubiquinone) 1 alpha subcomplex 4-like 2 in clear cell renal cell carcinoma
Journal Article
Minton, D. R., Fu, L., Mongan, N. P., Shevchuk, M. M., Nanus, D. M., & Gudas, L. J. (2016). Role of NADH Dehydrogenase (Ubiquinone) 1 alpha subcomplex 4-like 2 in clear cell renal cell carcinoma. Clinical Cancer Research, doi:10.1158/1078-0432.CCR-15-1511

PURPOSE We delineated the functions of the HIF1α target NADH Dehydrogenase (Ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2) in ccRCC and characterized NDUFA4L2 as a novel molecular target for ccRCC treatment. EXPERIMENTAL DESIGN We evalua... Read More

A multi-agent based cooperative approach to scheduling and routing
Journal Article
Martin, S., Ouelhadj, D., Beullens, P., Özcan, E., Juan, A. A., & Burke, E. (2016). A multi-agent based cooperative approach to scheduling and routing. European Journal of Operational Research, doi:10.1016/j.ejor.2016.02.045

In this study, we propose a general agent-based distributed framework where each agent is implementing a different metaheuristic/local search combination. Moreover, an agent continuously adapts itself during the search process using a direct cooperat... Read More

On the comparison of proof planning systems: Lambda-clam, Omega and IsaPlanner
Conference Proceeding
Dennis, L. A., Jamnik, M., & Pollet, M. (2005). On the comparison of proof planning systems: Lambda-clam, Omega and IsaPlanner. In W. Farmer, & J. Carette (Eds.),

We present a framework for describing proof planners. This framework is based around a decomposition of proof planners into planning states, proof language, proof plans, proof methods, proof revision, proof control and planning algorithms. We us... Read More

Two-Level Schwarz Preconditioners for Super Penalty Discontinuous Galerkin Methods
Journal Article
Antonietti, P. F., & Ayuso, B. (2007). Two-Level Schwarz Preconditioners for Super Penalty Discontinuous Galerkin Methods. Manuscript submitted for publication

We extend the construction and analysis of the non-overlapping Schwarz preconditioners proposed in Antonietti et al. [Math. Model. Numer. Anal., 41(1):21-54, 2007] and [Math. Model. Numer. Anal., submitted, 2006] to the (non-consistent) super penalty... Read More

Waxing into words: Virginia Woolf and the Westminster Abbey funeral effigies
Journal Article
Kore Schroder, L. Waxing into words: Virginia Woolf and the Westminster Abbey funeral effigies

This articles derives its methodology from an analysis of the figures in the historical collection of royal funeral effigies in Westminster Abbey, London. As historical representations these resist categorisation: are they to be read as human and pro... Read More

Selection of materials for IGBT modules to achieve stable short circuit failure behaviour
Conference Proceeding
Li, J., Yaqub, I., & Johnson, C. M. (in press). Selection of materials for IGBT modules to achieve stable short circuit failure behaviour

IGBT modules which can fail to stable short circuit mode have great allocations in electricity network related fields. Sn3.5Ag solder joint and sintered Ag joint for the die attachment and Mo, Cu, Sn3.5Ag, Al and Ag foils for the top side insert mate... Read More

Adaptivity and a posteriori error control for bifurcation problems III: incompressible fluid flow in open systems with O(2) symmetry
Journal Article
Cliffe, A., Hall, E., Houston, P., Phipps, E. T., & Salinger, A. G. (2012). Adaptivity and a posteriori error control for bifurcation problems III: incompressible fluid flow in open systems with O(2) symmetry. doi:10.1007/s10915-011-9545-8. Manuscript submitted for publication

In this article we consider the a posteriori error estimation and adaptive mesh refinement of discontinuous Galerkin finite element approximations of the bifurcation problem associated with the steady incompressible Navier-Stokes equations. Particula... Read More

Optimisation of a crossdocking distribution centre simulation model
Book Chapter
Adewunmi, A., & Aickelin, U. Optimisation of a crossdocking distribution centre simulation model. In Proceedings of the 2008 International Simulation Multi-conferenceThe Society For Modeling and Simulation International (SCS)

This paper reports on continuing research into the modelling of an order picking process within a Crossdocking distribution centre using Simulation Optimisation. The aim of this project is to optimise a discrete event simulation model and to unde... Read More

A Component Based Heuristic Search Method with AdaptivePerturbations for Hospital Personnel Scheduling
Journal Article
Li, J., Aickelin, U., & Burke, E. A Component Based Heuristic Search Method with AdaptivePerturbations for Hospital Personnel Scheduling

Nurse rostering is a complex scheduling problem that affects hospital personnel on a daily basis all over the world. This paper presents a new component-based approach with adaptive perturbations, for a nurse scheduling problem arising at a major UK... Read More

Receptors, sparks and waves in a fire-diffuse-fire framework for calcium release
Journal Article
Coombes, S., Hinch, R., & Timofeeva, Y. (2004). Receptors, sparks and waves in a fire-diffuse-fire framework for calcium release

Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. It is now well established that these waves are composed of elementary stochasti... Read More

The hidden costs of mental depression: implications on social trust and life satisfaction
Book
Chee-Ruey, H., Siyuan, L., & Xuezheng, Q. (in press). The hidden costs of mental depression: implications on social trust and life satisfaction. University of Nottingham

Mental health conditions such as depression is a rapidly rising epidemic and a major contributor to the overall global burden of disease. In addition to the direct medical costs and indirect economic costs that falls into the traditional boundary of... Read More

A simulation-based framework for a mapping tool that assesses the energy performance of green roofs
Conference Proceeding
Kokogiannakis, G., & Darkwa, J. A simulation-based framework for a mapping tool that assesses the energy performance of green roofs

This paper presents a framework for the development of a GIS open source mapping tool that aims to disseminate a database with results of detailed simulations in order to assess in a quick and easy way the energy performance of green roof designs acr... Read More

Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?
Journal Article
Howarth, B., Edmunds, M., & Gilbert, F. (2004). Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?. Evolution,

We tested the prediction that, if hoverflies are Batesian mimics, this may extend to behavioral mimicry such that their numerical abundance at each hour of the day (the daily activity pattern) is related to the numbers of their hymenopteran models. A... Read More

Exploring haemodynamics of haemodialysis using extrema points analysis model
Journal Article
Eldehni, M. T., Odudu, A., & McIntyre, C. W. Exploring haemodynamics of haemodialysis using extrema points analysis model. Theoretical Biology and Medical Modelling, 10, doi:10.1186/1742-4682-10-33

Background: Haemodialysis is a form of renal replacement therapy used to treat patients with end stage renal failure. It is becoming more appreciated that haemodialysis patients exhibit higher rates of multiple end organ damage compared to the gen... Read More

Integrity management and the public service ethos in the UK: patchwork quilt or threadbare blanket?
Conference Proceeding
Heywood, P. M. Integrity management and the public service ethos in the UK: patchwork quilt or threadbare blanket?

This paper focuses on the nature of integrity management in contemporary UK public life. Despite traditionally high standards of integrity in the public service, it has recently been argued that the UK’s National Integrity System resembles a patchwor... Read More

Regulation of cel genes of C. cellulolyticum: identification of GlyR2, a transcriptional regulator regulating cel5D gene expression
Journal Article
Fendri, I., Abdou, L., Trotter, V., Dedieu, L., Maamar, H., Minton, N. P., & Tardif, C. Regulation of cel genes of C. cellulolyticum: identification of GlyR2, a transcriptional regulator regulating cel5D gene expression. PLoS ONE, 8(1), doi:10.1371/journal.pone.0044708

Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, exc... Read More

Improving patient experience of cancer follow up: redesign and evaluation of adult cancer aftercare services for breast, colorectal, and testicular patients, at University Hospital Southampton NHS Foundation Trust
Conference Proceeding
Batehup, L., Corner, J., Porter, K., Simmonds, P., Lowson, E., Dodson, L., …Richardson, A. Improving patient experience of cancer follow up: redesign and evaluation of adult cancer aftercare services for breast, colorectal, and testicular patients, at University Hospital Southampton NHS Foundation Trust