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Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds (2018)
Journal Article
Wales, S. M., Merisor, E., Adcock, H., Pearce, C. A., Strutt, I., Lewis, W., …Moody, C. J. (2018). Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds. Chemistry - A European Journal, 24(32), 8233-8239. https://doi.org/10.1002/chem.201801046

A series of highly substituted tetrahydrofurans (THFs), decorated with modifiable 2‐aryl, 3‐carboxy and 4‐amino substituents, has been prepared for biological evaluation within the European Lead Factory. Diastereoselective reductive amination of pre‐... Read More about Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds.

Mindful organizing in patients’ contributions to primary care medication safety (2018)
Journal Article
Phipps, D. L., Giles, S., Lewis, P. J., Marsden, K., Salema, N., Jeffries, M., …Ashcroft, D. M. (2018). Mindful organizing in patients’ contributions to primary care medication safety. Health Expectations, 21(6), 964-972. https://doi.org/10.1111/hex.12689

Background: There is a need to ensure that the risks associated with medication usage in primary healthcare are controlled. To maintain an understanding of the risks, healthcare organizations may engage in a process known as “mindful organizing”. Whi... Read More about Mindful organizing in patients’ contributions to primary care medication safety.

Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication (2018)
Journal Article
Ahmed, C., Winlow, P. L., Parsons, A. L., & Jopling, C. L. (2018). Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication. Nucleic Acids Research, 46(12), https://doi.org/10.1093/nar/gky262

Hepatitis C virus (HCV) is a positive sense RNA virus that persistently infects human liver, leading to cirrhosis and hepatocellular carcinoma. HCV replication requires the liver-specific microRNA-122 (miR-122). In contrast to canonical miRNA-mediat... Read More about Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication.

On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling (2018)
Journal Article
Falcke, M., Moein, M., Tilunaite, A., Thul, R., & Skupin, A. (2018). On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling. Chaos, 28(4), Article 045115. https://doi.org/10.1063/1.5021073

The correspondence between mathematical structures and experimental systems is the basis of the generalizability of results found with specific systems, and is the basis of the predictive power of theoretical physics. While physicists have confidence... Read More about On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling.

Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study (2018)
Journal Article
Marshall, F., Basiri, A., Riley, M., Dening, T., Gladman, J. R., Griffiths, A., & Lewis, S. (2018). Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study. BMJ Open, 8(4), 1-10. https://doi.org/10.1136/bmjopen-2017-020374

Introduction: Scaling the Peaks is a cross-disciplinary research study which draws on medical ethnography, human geography and Geospatial Information Science (GIS) to address the issues surrounding the design and delivery of dementia friendly service... Read More about Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study.

Autistic traits in treatment-seeking transgender adults (2018)
Journal Article
Nobili, A., Glazebrook, C., Bouman, W. P., Glidden, D., Baron-Cohen, S., Allison, C., …Arcelus, J. (2018). Autistic traits in treatment-seeking transgender adults. Journal of Autism and Developmental Disorders, 48(12), 3984–3994. https://doi.org/10.1007/s10803-018-3557-2

The present study aimed to compare prevalence of autistic traits as measured by the Autism Spectrum Quotient-Short (AQ-Short) in a transgender clinical population (n=656) matched by age and sex assigned at birth to a typical cisgender community sampl... Read More about Autistic traits in treatment-seeking transgender adults.

Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis (2018)
Journal Article
Wang, J., Li, T., Elsheikha, H. M., Chen, K., Cong, W., Yang, W., …Zhu, X. (2018). Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis. Journal of Infectious Diseases, 218(5), 768–777. https://doi.org/10.1093/infdis/jiy211

Background: The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by live-attenuated strain of T.... Read More about Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis.

What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab? (2018)
Journal Article
Card, T. R., Xu, J., Liang, H., & Bhayat, F. (2018). What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?. Inflammatory Bowel Diseases, 24(5), https://doi.org/10.1093/ibd/izx097

Background: Progressive multifocal leukoencephalopathy is a serious condition linked to certain diseases and immunosuppressant therapies, including the α4 integrin antagonist natalizumab. No cases have been reported to date with vedolizumab, a select... Read More about What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?.

Parameterizations for ensemble Kalman inversion (2018)
Journal Article
Chada, N., Iglesias, M., Lassi, R., & Stuart, A. M. (2018). Parameterizations for ensemble Kalman inversion. Inverse Problems, 34(5), https://doi.org/10.1088/1361-6420/aab6d9

The use of ensemble methods to solve inverse problems is attractive because it is a derivative-free methodology which is also well-adapted to parallelization. In its basic iterative form the method produces an ensemble of solutions which lie in the l... Read More about Parameterizations for ensemble Kalman inversion.

Microwave-based preparation and characterization of Fe-cored carbon nanocapsules with novel stability and super electromagnetic wave absorption performance (2018)
Journal Article
Wang, Y., Wang, W., Sun, J., Sun, C., Feng, Y., & Li, Z. (2018). Microwave-based preparation and characterization of Fe-cored carbon nanocapsules with novel stability and super electromagnetic wave absorption performance. Carbon, 135, https://doi.org/10.1016/j.carbon.2018.04.026

Microwave-metal discharge was proposed as a facile methodology to prepare unique Fe-cored carbon nanocapsules (Fe@CNCs) with high purity, novel stability and extraordinary electromagnetic wave (EMW) absorption performance. The effect of microwave pow... Read More about Microwave-based preparation and characterization of Fe-cored carbon nanocapsules with novel stability and super electromagnetic wave absorption performance.

Haloquadratum walsbyi yields a versatile, NAD+/NADP+ dual affinity, thermostable, alcohol dehydrogenase (HwADH) (2018)
Journal Article
Cassidy, J., & Paradisi, F. (2018). Haloquadratum walsbyi yields a versatile, NAD+/NADP+ dual affinity, thermostable, alcohol dehydrogenase (HwADH). Molecular Biotechnology, 60(6), 420-426. https://doi.org/10.1007/s12033-018-0083-6

This study presents the first example of an alcohol dehydrogenase (ADH) from the halophilic archaeum Haloquadratum walsbyi (HwADH). A hexahistidine-tagged recombinant HwADH was heterologously overexpressed in Haloferax volcanii. HwADH was purified in... Read More about Haloquadratum walsbyi yields a versatile, NAD+/NADP+ dual affinity, thermostable, alcohol dehydrogenase (HwADH).

No Man is an Island (2018)
Other
Macleod, D. (2018). No Man is an Island. [Score]. London

A five-minute setting of John Donne's Mediation XVII written for solo voice and electronics. Premiered by SoundKarD at nonclassical, London. 12/04/2018.

United Kingdom: film funding, the "corporate welfare system" and its discontents (2018)
Book Chapter
Newsinger, J., & Prescence, S. (2018). United Kingdom: film funding, the "corporate welfare system" and its discontents. In P. Murschetz, R. Teichmann, & M. Karmasin (Eds.), Handbook of State Aid for Film: Finance, Industries and Regulation (447-462). Cham, Switzerland: Springer Publishing Company

Rape as 'one person's word against another's': challenging the conventional wisdom (2018)
Journal Article
Saunders, C. L. (2018). Rape as 'one person's word against another's': challenging the conventional wisdom. International Journal of Evidence and Proof, 22(2), https://doi.org/10.1177/1365712718766478

According to the conventional wisdom, rape is generally a case of ‘one person’s word against another’s’ and, in the absence of independent evidence, judgements regarding the truth or otherwise of an allegation are influenced by ‘rape myths’ and gende... Read More about Rape as 'one person's word against another's': challenging the conventional wisdom.

Comparative Thermal and Structural Characterization of Sintered Nano-Silver and High-Lead Solder Die Attachments During Power Cycling (2018)
Journal Article
Dai, J., Li, J., Agyakwa, P., Corfield, M., & Johnson, C. M. (2018). Comparative Thermal and Structural Characterization of Sintered Nano-Silver and High-Lead Solder Die Attachments During Power Cycling. IEEE Transactions on Device and Materials Reliability, 18(2), 256-265. https://doi.org/10.1109/TDMR.2018.2825386

13.5 mm × 13.5 mm sintered nano-silver attachments for power devices onto AlN substrates were prepared at 250 ºC and a pressure of 10MPa for 5 minutes and compared with Pb5Sn solder joint die attachments under constant current power cycling with an i... Read More about Comparative Thermal and Structural Characterization of Sintered Nano-Silver and High-Lead Solder Die Attachments During Power Cycling.

A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate (2018)
Journal Article
Giehl, R. F. H., Bhosale, R., Giri, J., Pandey, B. K., Giehl, R. F., Hartmann, A., …Swarup, R. (2018). A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate. Nature Communications, 9(1), 1-9. https://doi.org/10.1038/s41467-018-03851-3

Phosphate (P) is an essential macronutrient for plant growth. Roots employ adaptive mechanisms to forage for P in soil. Root hair elongation is particularly important since P is immobile. Here we report that auxin plays a critical role promoting root... Read More about A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate.

Does bone mineral density improve the predictive accuracy of fracture risk assessment?: a prospective cohort study in Northern Denmark (2018)
Journal Article
Dhiman, P., Andersen, S., Vestergaard, P., Masud, T., & Qureshi, N. (2018). Does bone mineral density improve the predictive accuracy of fracture risk assessment?: a prospective cohort study in Northern Denmark. BMJ Open, 8, Article e018898. https://doi.org/10.1136/bmjopen-2017-018898

Objective: To evaluate the added predictive accuracy of bone mineral density (BMD) to fracture risk assessment.Design Prospective cohort study using data between 01 January 2010 and 31 December 2012. Setting: North Denmark Osteoporosis Clinic of r... Read More about Does bone mineral density improve the predictive accuracy of fracture risk assessment?: a prospective cohort study in Northern Denmark.

Developing the multiple stress–strain creep recovery (MS-SCR) test (2018)
Journal Article
Elnasri, M. M. H., Airey, G., & Thom, N. (in press). Developing the multiple stress–strain creep recovery (MS-SCR) test. Mechanics of Time-Dependent Materials, https://doi.org/10.1007/s11043-018-9387-y

While most published work from Europe has been concerned with evaluating binders’ resistance to rutting based on their stiffness (deformation resistance), work originating in the US has mainly been concerned with ranking binders based on their recove... Read More about Developing the multiple stress–strain creep recovery (MS-SCR) test.