Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M.L.; Yeatman, H.R.; Nowell, C.J.; Thompson, G.L.; Gondin, A.B.; Civciristov, S.; Bunnett, N.W.; Lambert, N.A.; Poole, D.P.; Canals, M.

doi:10.1126/scisignal.aac9177

All Outputs (4308)

Mechanisms of monovacancy diffusion in graphene (2016)
Journal Article
Wadey, J. D., Markevich, A., Robertson, A., Warner, J., Kirkland, A., & Besley, E. (2016). Mechanisms of monovacancy diffusion in graphene. Chemical Physics Letters, 648, 161-165. https://doi.org/10.1016/j.cplett.2016.02.005

A comprehensive investigation of monovacancy diffusion in graphene has been carried out with the use of density functional theory and the climbing image nudged elastic band method. An out-of-plane spiro structure is found for the first-order saddle p... Read More about Mechanisms of monovacancy diffusion in graphene.

Response to: ‘Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women’ by Gao et al (2016)
Journal Article
Kluzek, S., Sanchez-Santos, M. T., Leyland, K. M., Judge, A., Newton, J., & Arden, N. K. (2016). Response to: ‘Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women’ by Gao et al. Annals of the Rheumatic Diseases, 75(4), Article e23. https://doi.org/10.1136/annrheumdis-2015-209029

Towards universal quantum computation through relativistic motion (2016)
Journal Article
Bruschi, D. E., Sabín, C., Kok, P., Johansson, G., Delsing, P., & Fuentes, I. (2016). Towards universal quantum computation through relativistic motion. Scientific Reports, 6, Article 18349. https://doi.org/10.1038/srep18349

We show how to use relativistic motion to generate continuous variable Gaussian cluster states within cavity modes. Our results can be demonstrated experimentally using superconducting circuits where tuneable boundary conditions correspond to mirrors... Read More about Towards universal quantum computation through relativistic motion.

Tensile and Bond Characterization of Natural Fibers Embeeded in Inorganic Matrices (2016)
Conference Proceeding
Ghiassi, B., Razavizadeh, A., Oliveira, D. V., Marques, V., & Lourenço, P. B. (2016). Tensile and Bond Characterization of Natural Fibers Embeeded in Inorganic Matrices. In Natural Fibres: Advances in Science and Technology Towards Industrial Applications (305-314). https://doi.org/10.1007/978-94-017-7515-1_23

Innovative composite materials made of continuous fibers embedded in mortar matrices have been recently received attention for externally bonded reinforcement of masonry structures. In this regards, application of natural fibers for strengthening of... Read More about Tensile and Bond Characterization of Natural Fibers Embeeded in Inorganic Matrices.

Silent professionalization: EU integration and the professional socialization of public officials in Central and Eastern Europe (2016)
Journal Article
Meyer-Sahling, J., Lowe, W., & van Stolk, C. (2016). Silent professionalization: EU integration and the professional socialization of public officials in Central and Eastern Europe. European Union Politics, 17(1), 162-183. https://doi.org/10.1177/1465116515608270

This paper applies theories of international socialization to examine the impact of European Union contact on the professional socialization of public officials in Central and Eastern Europe. Based on a survey of officials in seven new member states,... Read More about Silent professionalization: EU integration and the professional socialization of public officials in Central and Eastern Europe.

Layer methods for stochastic Navier–Stokes equations using simplest characteristics (2016)
Journal Article
Milstein, G., & Tretyakov, M. (2016). Layer methods for stochastic Navier–Stokes equations using simplest characteristics. Journal of Computational and Applied Mathematics, 302, https://doi.org/10.1016/j.cam.2016.01.051

We propose and study a layer method for stochastic Navier-Stokes equations (SNSE) with spatial periodic boundary conditions and additive noise. The method is constructed using conditional probabilistic representations of solutions to SNSE and exploit... Read More about Layer methods for stochastic Navier–Stokes equations using simplest characteristics.

New insights into xanthan synergistic interactions with konjacglucomannan: a novel interaction mechanism proposal (2016)
Journal Article
Abbaszadeh, A., Macnaughtan, W., Sworn, G., & Foster, T. J. (2016). New insights into xanthan synergistic interactions with konjacglucomannan: a novel interaction mechanism proposal. Carbohydrate Polymers, 144, https://doi.org/10.1016/j.carbpol.2016.02.026

The interactions of xanthans containing precise acetate and pyruvate concentration with Konjac gluco-mannan (KGM) were studied at different sodium chloride and polymer concentrations. A new unifiedmodel of the interaction is proposed, taking into acc... Read More about New insights into xanthan synergistic interactions with konjacglucomannan: a novel interaction mechanism proposal.

Parametric study on the regeneration heat requirement of an amine-based solid adsorbent process for post-combustion carbon capture (2016)
Journal Article
Zhang, W., Liu, H., Sun, Y., Cakstins, J., Sun, C., & Snape, C. E. (2016). Parametric study on the regeneration heat requirement of an amine-based solid adsorbent process for post-combustion carbon capture. Applied Energy, 168, 394-405. https://doi.org/10.1016/j.apenergy.2016.01.049

The thermal energy required for regeneration of CO2-rich adsorbents or absorbents is usually regarded as the most important criterion to evaluate different materials and processes for application in commercialscale CO2 capture systems. It is expected... Read More about Parametric study on the regeneration heat requirement of an amine-based solid adsorbent process for post-combustion carbon capture.

Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging (2016)
Journal Article
Parker, H. L., Tucker, E., Hoad, C., Pal, A., Costigan, C., Hudders, N., …Fox, M. R. (2016). Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging. Neurogastroenterology and Motility, 28(4), 554-568. https://doi.org/10.1111/nmo.12752

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Mea... Read More about Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging.

Understanding anionic Chugaev elimination in pericyclic tetracene formation (2016)
Journal Article
Burroughs, L., Ritchie, J., & Woodward, S. (2016). Understanding anionic Chugaev elimination in pericyclic tetracene formation. Tetrahedron, 72(13), https://doi.org/10.1016/j.tet.2016.02.025

The reaction pathway for the formation of tetracenes from the diols 1,2-C6H4(CHOHC?CAr)2 , LiHDMS, CS2 and MeI has been modelled by computational methods at the CBS-QB3 level of theory. Comparison of PhCHOC(=S)YCCPh (Y = S- or SMe) indicates a sligh... Read More about Understanding anionic Chugaev elimination in pericyclic tetracene formation.

nIFTy galaxy cluster simulations – I. Dark matter and non-radiative models (2016)
Journal Article
Sembolini, F., Yepes, G., Pearce, F. R., Knebe, A., Kay, S. T., Power, C., …Thacker, R. J. (in press). nIFTy galaxy cluster simulations – I. Dark matter and non-radiative models. Monthly Notices of the Royal Astronomical Society, 457(4), https://doi.org/10.1093/mnras/stw250

We have simulated the formation of a galaxy cluster in a ? cold dark matter universe using 13 different codes modelling only gravity and non-radiative hydrodynamics (RAMSES, ART, AREPO, HYDRA and nine incarnations of GADGET). This range of codes incl... Read More about nIFTy galaxy cluster simulations – I. Dark matter and non-radiative models.

Low energy Lorentz violation from modified dispersion at high energies (2016)
Journal Article
Husain, V., & Louko, J. (in press). Low energy Lorentz violation from modified dispersion at high energies. Physical Review Letters, 116(6), https://doi.org/10.1103/PhysRevLett.116.061301

Adaptive energy minimisation for hp-finite element methods (2016)
Journal Article
Houston, P., & Wihler, T. P. (2016). Adaptive energy minimisation for hp-finite element methods. Computers and Mathematics with Applications, 71(4), https://doi.org/10.1016/j.camwa.2016.01.002

This article is concerned with the numerical solution of convex variational problems. More precisely, we develop an iterative minimisation technique which allows for the successive enrichment of an underlying discrete approximation space in an adapti... Read More about Adaptive energy minimisation for hp-finite element methods.

H-ATLAS: the far-infrared properties of galaxies in and around the Coma cluster (2016)
Journal Article
Fuller, C., Davies, J., Smith, M., Valiante, E., Eales, S., Bourne, N., …Davis, T. (2016). H-ATLAS: the far-infrared properties of galaxies in and around the Coma cluster. Monthly Notices of the Royal Astronomical Society, 458(1), 582-602. https://doi.org/10.1093/mnras/stw305

We describe a far-infrared survey of the Coma cluster and the galaxy filament it resides within. Our survey covers an area of ∼150 deg2 observed by Herschel H-ATLAS (Herschel Astrophysical Terahertz Large Area Survey) in five bands at 100, 160, 250,... Read More about H-ATLAS: the far-infrared properties of galaxies in and around the Coma cluster.

Hybrid HVDC circuit breaker with self-powered gate drives (2016)
Journal Article
Effah, F. B., Watson, A. J., Ji, C., Amankwah, E. K., Johnson, C. M., Davidson, C., & Clare, J. C. (2016). Hybrid HVDC circuit breaker with self-powered gate drives. IET Power Electronics, 9(2), 228-236. https://doi.org/10.1049/iet-pel.2015.0531

The ever increasing electric power demand and the advent of renewable energy sources have revived the interest in high-voltage direct current (HVDC) multi-terminal networks. However, the absence of a suitable circuit breaker or fault tolerant VSC st... Read More about Hybrid HVDC circuit breaker with self-powered gate drives.

Flexible active compensation based on load conformity factors applied to non-sinusoidal and asymmetrical voltage conditions (2016)
Journal Article
Brandão, D. I., Parades, H. K., Costabeber, A., & Marafão, F. P. (2016). Flexible active compensation based on load conformity factors applied to non-sinusoidal and asymmetrical voltage conditions. IET Power Electronics, 9(2), 356-364. https://doi.org/10.1049/iet-pel.2015.0086

This study proposes a flexible active power filter (APF) controller operating selectively to satisfy a set of desired load performance indices defined at the source side. The definition of such indices, and of the corresponding current references, is... Read More about Flexible active compensation based on load conformity factors applied to non-sinusoidal and asymmetrical voltage conditions.

The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults (2016)
Journal Article
Chowdhury, E. A., Richardson, J. D., Holman, G. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults. American Journal of Clinical Nutrition, 103(3), https://doi.org/10.3945/ajcn.115.122044

Background: The causal nature of associations between breakfast and health remain unclear in obese individuals. Objective: We sought to conduct a randomized controlled trial to examine causal links between breakfast habits and components of energy b... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults.

The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma (2016)
Journal Article
Fredholm, S., Livinov, I., Mongan, N. P., Schiele, S., Willerslev-Olsen, A., Petersen, D. L., …Ødum, N. (2016). The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology, 136(4), 866-869. https://doi.org/10.1016/j.jid.2015.12.033

REFLECTIVE EPISTEMOLOGICAL DISJUNCTIVISM (2016)
Journal Article
Cunningham, J. (2016). REFLECTIVE EPISTEMOLOGICAL DISJUNCTIVISM. Episteme, 13(1), 111-132. https://doi.org/10.1017/epi.2015.62

It is now common to distinguish Metaphysical from Epistemological Disjunctivism. It is equally common to suggest that it is at least not obvious that the latter requires a commitment to the former: at the very least, a suitable bridge principle will... Read More about REFLECTIVE EPISTEMOLOGICAL DISJUNCTIVISM.

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling (2016)
Journal Article
Halls, M., Yeatman, H., Nowell, C., Thompson, G., Gondin, A., Civciristov, S., …Canals, M. (2016). Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling. Science Signaling, 9(414), ra16-ra16. https://doi.org/10.1126/scisignal.aac9177

Differential regulation of the μ-opioid receptor (MOR), a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor, contributes to the clinically limiting effects of opioid analgesics, such as morphine. We used biophysical appro... Read More about Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.