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All Outputs (576)

Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop (2022)
Journal Article
Bell, R. M., Basalay, M., Bøtker, H. E., Beikoghli Kalkhoran, S., Carr, R. D., Cunningham, J., …Yellon, D. M. (2022). Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop. Basic Research in Cardiology, 117, Article 39. https://doi.org/10.1007/s00395-022-00947-2

The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from th... Read More about Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop.

A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes (2022)
Journal Article
Ruaux, S., & Chadborn, N. (2023). A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes. Journal of Integrated Care, 31(1), 64-74. https://doi.org/10.1108/JICA-11-2021-0060

Purpose: Older people who reside in care homes have varying access and quality of medical care; in the UK, this is provided by general practitioners (GPs). The authors aimed to explore the experiences of trainee GPs in delivering integrated care and... Read More about A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes.

Breastfeeding in infants diagnosed with phenylketonuria (2022)
Journal Article
Chong, L., Kalvala, J., Chadborn, N., & Ojha, S. (2022). Breastfeeding in infants diagnosed with phenylketonuria. Cochrane Database of Systematic Reviews, 2022(8), 1-11. https://doi.org/10.1002/14651858.CD015243

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of breastfeeding (exclusive or partial) compared to low-Phe formula feeding in the first six months after birth in infants diag... Read More about Breastfeeding in infants diagnosed with phenylketonuria.

Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability (2022)
Journal Article
Ely, I. A., Jones, E. J., Inns, T. B., Dooley, S., Miller, S. B. J., Stashuk, D. W., …Piasecki, M. (2022). Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability. Experimental Physiology, https://doi.org/10.1113/EP090367

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit... Read More about Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability.

Defining improvement in chronic kidney disease: regression and remission (2022)
Journal Article
Taal, M. W. (2022). Defining improvement in chronic kidney disease: regression and remission. Current Opinion in Nephrology and Hypertension, 31(6), 517-521. https://doi.org/10.1097/MNH.0000000000000830

Purpose of review: International definitions exist for chronic kidney disease (CKD) progression and kidney failure but despite evidence that kidney function may improve, there are no agreed definitions for regression and remission of CKD. In the ligh... Read More about Defining improvement in chronic kidney disease: regression and remission.

Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry (2022)
Journal Article
Bain, J. T., Taal, M. W., Selby, N. M., Reynolds, J. C., & Heaney, L. M. (2022). Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry. Journal of Mass Spectrometry & Advances in the Clinical Lab, 25, 36-43. https://doi.org/10.1016/j.jmsacl.2022.07.002

Introduction The quantitative measurement of circulating gut bacteria-derived metabolites has increased in recent years due to their associations with health and disease. While much of the previous attention has been placed on metabolites consider... Read More about Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry.

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT (2022)
Journal Article
Wyld, L., Reed, M. W., Collins, K., Ward, S., Holmes, G., Morgan, J., …Parmeshwar, R. (2022). Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Programme Grants for Applied Research, 10(6), 1-114. https://doi.org/10.3310/xzoe2552

Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr... Read More about Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT.

Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review (2022)
Journal Article
Battisti, N. M. L., De Glas, N., Soto-Perez-de-Celis, E., Liposits, G., Bringuier, M., Walko, C., …Brain, E. (2022). Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review. European Journal of Cancer, 172, 158-170. https://doi.org/10.1016/j.ejca.2022.05.039

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify p... Read More about Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.

The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research (2022)
Working Paper
Gladman, Logan, Gordon, Harwood, Goldberg, & Radford. (0000). The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research

It is with pleasure that we present this brochure outlining the work of the Centre for Rehabilitation and Ageing and Research (CRAR) at the University of Nottingham and its partner NHS Trusts in Nottingham, and Derby and Burton.

General practitioners' role in improving health care in care homes: a realist review (2022)
Journal Article
Chadborn, N. H., Devi, R., Goodman, C., Williams, C. D., Sartain, K., & Gordon, A. L. (2022). General practitioners' role in improving health care in care homes: a realist review. Family Practice, 40(1), 119-127. https://doi.org/10.1093/fampra/cmac071

Background: Despite recent focus on improving health care in care homes, it is unclear what role general practitioners (GPs) should play. To provide evidence for future practice we set out to explore how GPs have been involved in such improvement... Read More about General practitioners' role in improving health care in care homes: a realist review.

Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies (2022)
Journal Article
Crabtree, T., Ogendo, J. J., Vinogradova, Y., Gordon, J., & Idris, I. (2022). Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies. Expert Review of Endocrinology and Metabolism, https://doi.org/10.1080/17446651.2022.2079495

Introduction: Guidelines for type 2 diabetes (T2D) recommend individualized HbA1c targets to take into account patient age or frailty. We synthesized evidence from randomized controlled trials and observational studies for intensive glycemic control... Read More about Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies.

Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown (2022)
Journal Article
Brook, M. S., Stokes, T., Gorissen, S. H., Bass, J. J., McGlory, C., Cegielski, J., …Atherton, P. J. (2022). Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown. Journal of Cachexia, Sarcopenia and Muscle, https://doi.org/10.1002/jcsm.13005

Background: We determined the short-term (i.e. 4days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted-fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. Methods: Healthy... Read More about Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown.

NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022 (2022)
Working Paper
Gladman, J., Piasecki, M., & Frost, K. (0000). NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022

This paper gives summaries of the keynote lectures given and the research abstracts presented at the NIHR Nottingham Biomedical Research Centre Musculoskeletal theme virtual conference held on 24th and 25th February 2022. The purpose of the confere... Read More about NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article
Mistry, A., Shipley, L., Ojha, S., & Sharkey, D. (2022). Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(6), 597-602. https://doi.org/10.1136/archdischild-2021-322906

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Mandatory vaccination against COVID-19 for health and social care workers caring for older people (2022)
Journal Article
Gordon, A. L., Achterberg, W. P., & van Delden, J. J. M. (2022). Mandatory vaccination against COVID-19 for health and social care workers caring for older people. Age and Ageing, 51(4), Article afac097. https://doi.org/10.1093/ageing/afac097

The COVID-19 pandemic has particularly adversely affected older people with frailty and functional dependency. Essential regular contact with care staff has been evidenced as an important source of infection for this group. Vaccinating care staff can... Read More about Mandatory vaccination against COVID-19 for health and social care workers caring for older people.

Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists (2022)
Journal Article
Crabtree, T. S. J., Adamson, K., Reid, H., Barnes, D., Sivappriyan, S., Bickerton, A., …Ryder, R. E. J. (2022). Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists. Diabetes, Obesity and Metabolism, 24(7), 1398-1401. https://doi.org/10.1111/dom.14701

The ABCD semaglutide audit was designed to capture the routine clinical outcomes of people commenced on semaglutide in the UK. Previous work showed differential reductions in HbA1c and weight dependent on previous glucagon-like peptide-1 receptor ago... Read More about Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists.

Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others (2022)
Working Paper
Walker, K., Yates, J., Dening, T., Vollm, B., Tomlin, J., & Griffiths, C. Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others

Introduction Research evidence that can inform service provision and treatment requirements for older (aged 55 years and above) forensic mental health patients is lacking, particularly that which is based on patients’ own preferences and experience... Read More about Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others.

Advance Care Plans in UK care home residents: a service evaluation using a stepped wedge design (2022)
Journal Article
Garden, G., Usman, A., Readman, D., Storey, L., Wilkinson, L., Wilson, G., …Gladman, J. (2022). Advance Care Plans in UK care home residents: a service evaluation using a stepped wedge design. Age and Ageing, 51(3), Article afac069. https://doi.org/10.1093/ageing/afac069

Introduction Advance care planning (ACP) in care homes has high acceptance, increases the proportion of residents dying in place and reduces hospital admissions in research. We investigated whether ACP had similar outcomes when introduced during re... Read More about Advance Care Plans in UK care home residents: a service evaluation using a stepped wedge design.

Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial (2022)
Journal Article
Pszczolkowski, S., Sprigg, N., Woodhouse, L. J., Gallagher, R., Swienton, D., Law, Z. K., …Dineen, R. A. (2022). Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. JAMA Neurology, 79(5), 468-477. https://doi.org/10.1001/jamaneurol.2022.0217

Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the acute hematoma occur in 20% of people with acute spontaneous intracerebral hemorrhage (ICH). Tranexamic acid, a hemostatic agent that is under invest... Read More about Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial.