All Outputs (1375)

Field study assessing the performance of a patient-side blood test to determine neuter status in female cats based on detection of luteinising hormone (2018)
Journal Article
Morrow, L. D., Gruffydd-Jones, T. J., Skillings, E., Welsh, C. P., & Murray, J. K. (2019). Field study assessing the performance of a patient-side blood test to determine neuter status in female cats based on detection of luteinising hormone. Journal of Feline Medicine and Surgery, 21(6), 553-558. https://doi.org/10.1177/1098612x18792101

Objectives The aim of this study was to assess the performance of a patient-side blood test in determining neuter status in female cats. Methods Residual blood samples from female cats of unknown neuter status that were admitted to four cat adopti... Read More about Field study assessing the performance of a patient-side blood test to determine neuter status in female cats based on detection of luteinising hormone.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs (2018)
Journal Article
Morris, T., Paine, S. W., Viljanto, M., Hudson, S., Gower, S., Pittorino, M., & Colgan, S. (2018). The pharmacokinetics of orally administered butylscopolamine in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(6), 790-794. https://doi.org/10.1111/jvp.12701

The oral tablet formulation of butylscopolamine, which is available without prescription, is commonly used by trainers of racing greyhounds to treat functional urethral obstruction. As medication control of butylscopolamine is therefore required for... Read More about The pharmacokinetics of orally administered butylscopolamine in greyhound dogs.

A review of current indicators of welfare in captive elephants (Loxodonta africana and Elephas maximus) (2018)
Journal Article
Williams, E., Chadwick, C., Yon, L., & Asher, L. (2018). A review of current indicators of welfare in captive elephants (Loxodonta africana and Elephas maximus). Animal Welfare Journal, 27(3), 235-249. https://doi.org/10.7120/09627286.27.3.235

Concerns over elephant welfare in UK zoos have implications for their future in captivity. To monitor improvements made to elephant welfare in UK zoos, non-invasive, valid and reliable indicators of welfare are needed. Using a rapid review strategy a... Read More about A review of current indicators of welfare in captive elephants (Loxodonta africana and Elephas maximus).

A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response (2018)
Journal Article
Tang, Y., Foster, N., Jones, M. A., & Barrow, P. A. (2018). A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response. Infection and Immunity, 86(8), Article e00307-18. https://doi.org/10.1128/IAI.00307-18

Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces... Read More about A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response.

Use of statistical modelling to investigate the pathogenesis of claw horn disruption lesions in dairy cattle (2018)
Journal Article
Randall, L., Green, M., & Huxley, J. (2018). Use of statistical modelling to investigate the pathogenesis of claw horn disruption lesions in dairy cattle. Veterinary Journal, 238, 41-48. https://doi.org/10.1016/j.tvjl.2018.07.002

Claw horn disruption lesions (CHDLs) in dairy cattle account for a large proportion of lameness. The aim of this review is to provide an update on the evidence surrounding the pathogenesis of CHDLs, in the context of how statistical modelling has con... Read More about Use of statistical modelling to investigate the pathogenesis of claw horn disruption lesions in dairy cattle.

Impact of breast cancer grade discordance on prediction of outcome (2018)
Journal Article
Rakha, E. A., Aleskandarany, M. A., Toss, M. S., Mongan, N., El-Sayed, M. E., Green, A. R., …Dalton, L. W. (in press). Impact of breast cancer grade discordance on prediction of outcome. Histopathology, https://doi.org/10.1111/his.13709

BACKGROUND: Histological grade is an independent prognostic variable in breast cancer (BC). Previous concordance studies of BC grade have reported moderate levels of agreement; a typical finding in morphological assessment of biological variables. Th... Read More about Impact of breast cancer grade discordance on prediction of outcome.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

Measuring the success of canine and feline preventative healthcare consultations: a systematic review (2018)
Journal Article
Robinson, N., Belshaw, Z., Brennan, M. L., & Dean, R. S. (2018). Measuring the success of canine and feline preventative healthcare consultations: a systematic review. Preventive Veterinary Medicine, 158, 18-24. https://doi.org/10.1016/j.prevetmed.2018.07.005

Preventative healthcare consultations account for a large proportion of the veterinary caseload. This novel study is the first to methodically review all literature on canine and feline preventative healthcare consultations. Previous research has fo... Read More about Measuring the success of canine and feline preventative healthcare consultations: a systematic review.

Owner and veterinary surgeon perspectives on the roles of veterinary nurses and receptionists in relation to small animal preventative healthcare consultations in the United Kingdom (2018)
Journal Article
Belshaw, Z., Robinson, N. J., Dean, R. S., & Brennan, M. L. (2018). Owner and veterinary surgeon perspectives on the roles of veterinary nurses and receptionists in relation to small animal preventative healthcare consultations in the United Kingdom. Veterinary Record, 183(9), Article 296. https://doi.org/10.1136/vr.104773

Veterinary receptionists and veterinary nurses rarely feature in published practice-based research, yet are integral to small animal veterinary practice in the United Kingdom (UK). The aim of this study was to investigate the perspectives of UK-based... Read More about Owner and veterinary surgeon perspectives on the roles of veterinary nurses and receptionists in relation to small animal preventative healthcare consultations in the United Kingdom.

Therapeutic prospects of extracellular vesicles in cancer treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Therapeutic prospects of extracellular vesicles in cancer treatment. Frontiers in Immunology, 9, Article 1534. https://doi.org/10.3389/fimmu.2018.01534

Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nuc... Read More about Therapeutic prospects of extracellular vesicles in cancer treatment.

Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin (2018)
Journal Article
Agbaje, M., Rutland, C. S., Maboni, G., Blanchard, A., Bexon, M., Stewart, C., …Totemeyer, S. (2018). Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin. PeerJ, 6, Article e5097. https://doi.org/10.7717/peerj.5097

Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoofhorn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship w... Read More about Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin.

Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis (2018)
Journal Article
Zhang, N., Gao, Q., Wang, M., Elsheikha, H. M., Wang, B., Wang, J., …Zhu, X. (in press). Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.01505

Toxoplasmosis is a zoonotic disease caused by the intracellular protozoan Toxoplasma gondii; and a major source of infection in humans is via ingestion of T. gondii tissue cysts. Ultimately, the goal of anti-toxoplasmosis vaccines is to elicit a sust... Read More about Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis.

Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance (2018)
Journal Article
Althobiti, M., Aleskandarany, M. A., Joseph, C., Toss, M., Mongan, N., Diez-Rodriguez, M., …Rakha, E. A. (2018). Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance. Histopathology, 73(6), 887-896. https://doi.org/10.1111/his.13695

Background: Tumour-infiltrating lymphocytes (TILs) in breast cancer (BC) confer prognostic and predictive information. This study aims to assess the spatial and temporal heterogeneity of TILs in BC and its relationship with immune cell subtypes. Met... Read More about Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance.

Pathological findings in the pituitary glands of 201 dogs and cats (2018)
Journal Article
Polledo, L., Grinwis, G. C., Graham, P., Dunning, M., & Baiker, K. (2018). Pathological findings in the pituitary glands of 201 dogs and cats. Veterinary Pathology, 55(6), 880-888. https://doi.org/10.1177/0300985818784162

With the exception of classic functional adenomas in dogs and horses, pituitary lesions are infrequently described in the veterinary literature. Approximately 10% of pituitary glands from asymptomatic humans contain abnormalities but the equivalent p... Read More about Pathological findings in the pituitary glands of 201 dogs and cats.

Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15 (2018)
Journal Article
Liu, Q., Gao, W., Elsheikha, H. M., He, J., Li, F., Yang, W., & Zhu, X. (2018). Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15. Parasitology Research, 117(9), 2785–2793. https://doi.org/10.1007/s00436-018-5966-8

Growth and replication of the protozoan parasite Toxoplasma gondii within host cell entail the production of several effector proteins, which the parasite exploits for counteracting the host’s immune response. Despite considerable research to define... Read More about Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15.

Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective (2018)
Journal Article
Lahuerta-Marin, A., Brennan, M., Finney, G., O’Hagan, M., & Jack, C. (in press). Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective. Irish Veterinary Journal, 71(1), https://doi.org/10.1186/s13620-018-0125-1

Background: Agriculture and farming are valued contributors to local economy in Northern Ireland (NI). There is limited knowledge about farmers’ behaviours and attitudes towards disease biosecurity measures. As part of a larger project, a scenario-ba... Read More about Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective.

Toxocariasis: a silent threat with a progressive public health impact (2018)
Journal Article
Chen, J., Liu, Q., Liu, G., Zheng, W., Hong, S., Sugiyama, H., …Elsheikha, H. M. (in press). Toxocariasis: a silent threat with a progressive public health impact. Infectious Diseases of Poverty, 7(1), https://doi.org/10.1186/s40249-018-0437-0

Background: Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide, especially in impoverished communities. This disease is caused by infection with the larvae of Toxocara canis and... Read More about Toxocariasis: a silent threat with a progressive public health impact.

A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses (2018)
Journal Article
Tian, A., Elsheikha, H. M., Zhou, D., Wu, Y., Chen, M., Wang, M., …Zhu, X. (2018). A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses. Veterinary Parasitology, 258, https://doi.org/10.1016/j.vetpar.2018.06.004

The development of a method to rapidly diagnose Neospora caninum infection is highly desirable. Recombinase polymerase amplification (RPA), combined with lateral flow (LF) strips, is a novel approach to rapidly amplify and visualize DNA. We have deve... Read More about A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses.

A retrospective review of great ape cardiovascular disease epidemiology and pathology (2018)
Journal Article
Strong, V. J., Martin, M., Redrobe, S., White, K., & Baiker, K. (2018). A retrospective review of great ape cardiovascular disease epidemiology and pathology. International Zoo Yearbook, 52(1), 113-125. https://doi.org/10.1111/izy.12193

Cardiovascular disease is associated with significant mortality in zoo-housed great apes and yet little is know about its epidemiology and aetiopathogenesis, and therefore its diagnosis, treatment and prevention. In this retrospective study, the fre... Read More about A retrospective review of great ape cardiovascular disease epidemiology and pathology.

Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis (2018)
Journal Article
White, C., Jones, G., Baker, S., Dean, R., & Brennan, M. (2018). Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis. Veterinary Sciences, 5(2), https://doi.org/10.3390/vetsci5020054

Treatment variation in medicine may be driven by evidence gaps, clinician factors, and patient preferences. Although well-documented in human medicine, variation in clinical management is relatively unexplored in veterinary practice. Clinical vignett... Read More about Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis.