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All Outputs (1290)

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles (2019)
Journal Article
Bruce, G., Samperi, M., Amabilino, D. B., Duch, M., Plaza, J. A., & Pérez-García, L. (2019). Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles. Journal of Porphyrins and Phthalocyanines, 23(01n02), 223-233. https://doi.org/10.1142/s1088424619500226

© 2019 World Scientific Publishing Company. The generation of singlet oxygen (SO), primarily by using a combination of light and photosensitizers in the presence of a dissolved gas, finds applications in both chemistry and medicine. The efficiency of... Read More about Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles.

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples (2019)
Journal Article
Dooley, M., Prasopthum, A., Liao, Z., Sinjab, F., Mclaren, J., Rose, F. R. A. J., …Notingher, I. (2019). Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples. Biomedical Optics Express, 10(4), 1678-1690. https://doi.org/10.1364/BOE.10.001678

Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively the mineralization of bone tissue engineering scaffold in-vivo. The phantom samples consisted of 3D-printed s... Read More about Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples.

Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC) (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC). AAPS PharmSciTech, 20(3), https://doi.org/10.1208/s12249-019-1346-7

Surface - modified nanostructured lipid carriers (NLC) is a promising formulation to prolong the retention time of the therapeutic agent at the site of absorption. Chitosan-coated AmpB-loaded NLC (ChiAmpB NLC) were developed showing particle size of... Read More about Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC).

Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study (2019)
Journal Article
Wright, D., Little, R., Turner, D., & Thornley, T. (2019). Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study. Pharmacy, 7(1), Article 30. https://doi.org/10.3390/pharmacy7010030

Community pharmacies are commonly used to screen for patients with diabetes. The aim of this paper is to estimate the cost per test and cost per appropriately referred patient from a pharmacy perspective using a one-year decision tree model. One-way... Read More about Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study.

Making medications stick: improving medication adherence by highlighting the personal health costs of non-compliance (2019)
Journal Article
Jachimowicz, J. M., Gladstone, J. J., Berry, D., Kirkdale, C. L., Thornley, T., & Galinsky, A. D. (2021). Making medications stick: improving medication adherence by highlighting the personal health costs of non-compliance. Behavioural Public Policy, 5(3), 396-416. https://doi.org/10.1017/bpp.2019.1

Poor compliance of prescription medication is an ongoing public health crisis. Nearly half of patients do not take their medication as prescribed, harming their own health while also increasing public health care costs. Despite these detrimental cons... Read More about Making medications stick: improving medication adherence by highlighting the personal health costs of non-compliance.

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, 51(3), 481-493. https://doi.org/10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More about New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis (2019)
Journal Article
Zee, R. S., Mbanefo, E. C., Le, L. H., Pennington, L. F., Odegaard, J., Jardetzky, T. S., …Hsieh, M. H. (2019). IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis. AJP - Renal Physiology, 316(6), F1133-F1140. https://doi.org/10.1152/ajprenal.00468.2018

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic adminis... Read More about IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding (2019)
Journal Article
Airhihen, B., Pavanello, L., Jadhav, G. P., Fischer, P. M., & Winkler, G. S. (2019). 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding. FEBS Open Bio, 9(4), 717-727. https://doi.org/10.1002/2211-5463.12605

In eukaryotic cells, cytoplasmic mRNA is characterised by a 3’ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation. Using recombinant... Read More about 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding.

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors (2019)
Journal Article
Yao, H., Xu, F., Wang, G., Xie, S., Li, W., Yao, H., …Xu, S. (2019). Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. European Journal of Medicinal Chemistry, 167, 485-498. https://doi.org/10.1016/j.ejmech.2019.02.014

A series of novel B and C-rings truncated deguelin derivatives have been designed and synthesized in the present study as heat shock protein 90 (Hsp90) inhibitors. The synthesized compounds exhibited micromolar antiproliferative potency toward a pane... Read More about Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces (2019)
Journal Article
Sanjuan-Alberte, P., Saleh, E., Shaw, A. J., Lacalendola, N., Willmott, G., Vaithilingam, J., …Rawson, F. J. (2019). Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces. ACS Applied Materials and Interfaces, 11(9), 8928-8936. https://doi.org/10.1021/acsami.8b22075

There is a pressing need to advance our ability to construct three-dimensional (3D) functional bioelectronic interfaces. Additionally, to ease the transition to building cellular electronic systems, a remote approach to merge electrical components wi... Read More about Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces.

Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly (2019)
Journal Article
Di Palma, G., Kotowska, A. M., Hart, L. R., Scurr, D. J., Rawson, F. J., Tommasone, S., & Mendes, P. M. (2019). Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly. ACS Applied Materials and Interfaces, 11(9), 8937-8944. https://doi.org/10.1021/acsami.9b00927

The ability to design surfaces with reversible, high-affinity protein binding sites represents a significant step forward in the advancement of analytical methods for diverse biochemical and biomedical applications. Herein, we report a dynamic supram... Read More about Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly.

Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling (2019)
Journal Article
Alazzo, A., Al-Natour, M., Spriggs, K., Stolnik, S., Ghaemmaghami, A., Kim, D., & Alexander, C. (2019). Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling. Molecular Omics, 15(1), 77-87. https://doi.org/10.1039/C8MO00139A

Cationic polymers have emerged as a promising alternative to viral vectors in gene therapy. They are cheap to scale up, easy to functionalise and also presume to be safer than the viral vectors, however many of them are cytotoxic. The large number of... Read More about Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling.

Antibiotic prescribing for residents in long-term-care facilities across the UK (2019)
Journal Article
Thornley, T., Ashiru-Oredope, D., Normington, A., Beech, E., & Howard, P. (2019). Antibiotic prescribing for residents in long-term-care facilities across the UK. Journal of Antimicrobial Chemotherapy, 74(5), 1447-1451. https://doi.org/10.1093/jac/dkz008

Background: Antimicrobial resistance (AMR) is a major public health problem. Elderly residents in long-term-care facilities (LTCFs) are frequently prescribed antibiotics, particularly for urinary tract infections. Optimizing appropriate antibiotic us... Read More about Antibiotic prescribing for residents in long-term-care facilities across the UK.

Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells (2019)
Journal Article
Harrison, R. P., Chauhan, V. M., Onion, D., Aylott, J. W., & Sottile, V. (2019). Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells. RSC Advances, 9(6), 3176-3184. https://doi.org/10.1039/C8RA09089K

Silica-coated Superparamagnetic Iron Nanoparticles (SiMAGs) are an exciting biomedical technology capable of targeted delivery of cell-based therapeutics and disease diagnosis. However, in order to realise their full clinical potential, their intrace... Read More about Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells.

A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells (2019)
Journal Article
Aladdad, A. M., Amer, M. H., Sidney, L., Hopkinson, A., White, L. J., Alexander, C., & Rose, F. R. (2019). A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells. Acta Biomaterialia, 95, 427-438. https://doi.org/10.1016/j.actbio.2019.01.037

A three-dimensional thermoresponsive fibrous scaffold system for the subsequent extended culture and enzyme-free passaging of a range of mammalian cell types is presented. Poly(PEGMA188) was incorporated with poly(ethylene terephthalate) (PET) via bl... Read More about A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells.

Development of novel apoferritin formulations for antitumour benzothiazoles (2019)
Journal Article
Breen, A. F., Wells, G., Turyanska, L., & Bradshaw, T. D. (2019). Development of novel apoferritin formulations for antitumour benzothiazoles. Cancer Reports, 2(4), 1-7. https://doi.org/10.1002/cnr2.1155

Background The benzothiazole structure is important in medicinal chemistry, and 5‐fluoro‐2‐(3,4‐dimethoxyphenyl) benzothiazole (GW 610) is of particular interest as it shows outstanding anticancer activity in sensitive breast and colorectal carcinom... Read More about Development of novel apoferritin formulations for antitumour benzothiazoles.

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model (2019)
Journal Article
Markides, H., Newell, K. J., Rudorf, H., Ferreras, L. B., Dixon, J. E., Morris, R. H., …El Haj, A. J. (2019). Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model. Stem Cell Research and Therapy, 10, 1-15. https://doi.org/10.1186/s13287-018-1123-7

Background Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts. Pre-clinical studies... Read More about Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model.

Lipids and polymers in pharmaceutical technology: lifelong companions (2019)
Journal Article
Siepmann, J., Faham, A., Clas, S., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., …Leroux, J. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, st... Read More about Lipids and polymers in pharmaceutical technology: lifelong companions.