All Outputs (181)

Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions (2022)
Journal Article
Hutter, J., Kohli, V., Dellschaft, N., Uus, A., Story, L., Steinweg, J. K., …Rutherford, M. A. (2022). Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions. Scientific Reports, 12(1), Article 18542. https://doi.org/10.1038/s41598-022-22008-3

Pre-labour uterine contractions, occurring throughout pregnancy, are an important phenomenon involving the placenta in addition to the myometrium. They alter the uterine environment and thus potentially the blood supply to the fetus and may thus prov... Read More about Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions.

Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium (2022)
Journal Article
Maitra, R., Horne, C. M., O'Daly, O., Papanastasiou, E., Gaser, C., Banaschewski, T., …IMAGEN Consortium. (2023). Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium. Schizophrenia Bulletin, 49(2), 309-318. https://doi.org/10.1093/schbul/sbac132

Background and Hypothesis Psychotic Like Experiences (PLEs) are widely prevalent in children and adolescents and increase the risk of developing psychosis. Cortical gyrification characterizes brain development from in utero till about the first 2 ye... Read More about Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium.

A causal association of ANKRD37 with human hippocampal volume (2022)
Journal Article
Xu, J., Xia, X., Li, Q., Dou, Y., Suo, X., Liu, N., …Consortium, I. (2022). A causal association of ANKRD37 with human hippocampal volume. Molecular Psychiatry, 27, 4432-4445. https://doi.org/10.1038/s41380-022-01800-7

Human hippocampal volume has been separately associated with single nucleotide polymorphisms (SNPs), DNA methylation and gene expression, but their causal relationships remain largely unknown. Here, we aimed at identifying the causal relationships of... Read More about A causal association of ANKRD37 with human hippocampal volume.

Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use (2022)
Journal Article
Perkins, E. R., Joyner, K. J., Foell, J., Drislane, L. E., Brislin, S. J., Frick, P. J., …Consortium, T. I. (2022). Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use. Journal of Psychopathology and Clinical Science, 131(7), 793-807. https://doi.org/10.1037/abn0000743

This study explored the generality versus specificity of two trait-liability factors for externalizing problems — disinhibition and callousness — in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperact... Read More about Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use.

Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium (2022)
Journal Article
de Erausquin, G. A., Snyder, H., Brugha, T. S., Seshadri, S., Carrillo, M., Sagar, R., …Vahidy, F. S. (2022). Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 8(1), Article e12348. https://doi.org/10.1002/trc2.12348

Introduction: Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervo... Read More about Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.

Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence (2022)
Journal Article
Nees, F., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Grigis, A., Garavan, H., …on behalf of the IMAGEN Consortium. (2022). Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence. Brain Sciences, 12(9), Article 1187. https://doi.org/10.3390/brainsci12091187

Background: Autistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brai... Read More about Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.

Swallow Tail Sign: Revisited (2022)
Journal Article
Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P., Jantzen, C., Jäger, C., …Weiskopf, N. (2022). Swallow Tail Sign: Revisited. Radiology, 305(3), 674-677. https://doi.org/10.1148/radiol.212696

The loss of the radiologic swallow tail sign on MRI scans of the substantia nigra is a promising diagnostic marker of Parkinson disease (1), although its anatom-ic underpinning is unclear. An early influential study showed th... Read More about Swallow Tail Sign: Revisited.

Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning (2022)
Journal Article
Owens, M. M., Albaugh, M. D., Allgaier, N., Yuan, D., Robert, G., Cupertino, R. B., …Hohmann, S. (2022). Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning. Translational Psychiatry, 12(1), Article 188. https://doi.org/10.1038/s41398-022-01956-4

While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationshi... Read More about Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning.

Autistic traits and alcohol use in adolescents within the general population (2022)
Journal Article
Pijnenburg, L. J., Kaplun, A., de Haan, L., Janecka, M., Smith, L., Reichenberg, A., …IMAGEN Consortium. (2023). Autistic traits and alcohol use in adolescents within the general population. European Child and Adolescent Psychiatry, 32(9), 1633–1642. https://doi.org/10.1007/s00787-022-01970-3

It has been suggested that autistic traits are associated with less frequent alcohol use in adolescence. Our study seeks to examine the relationship between autistic traits and alcohol use in a large adolescent population. Leveraging data from the IM... Read More about Autistic traits and alcohol use in adolescents within the general population.

Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial) (2022)
Journal Article
Carneiro, L., White, J., Parker, H., Hoad, C., Tucker, E., Marciani, L., …Fox, M. (2022). Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial). Nutrients, 14(7), Article 1321. https://doi.org/10.3390/nu14071321

Nausea, vomiting and abdominal pain in diabetic patients are often attributed to diabetic gastropathy (DG). Post-pyloric (“jejunal”) enteral nutrition (JN) may improve nutrition and glycaemia in difficult cases. The acute effects of JN on postprandia... Read More about Pilot Double-Blind Randomised Controlled Trial: Effects of Jejunal Nutrition on Postprandial Distress in Diabetic Gastropathy (J4G Trial).

A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood (2022)
Journal Article
Kaiser, A., Holz, N. E., Banaschewski, T., Baumeister, S., Bokde, A. L. W., Desrivières, S., …Nees, F. (2022). A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(11), 1103-1115. https://doi.org/10.1016/j.bpsc.2022.02.003

Background: On a theoretical level, impulsivity represents a multidimensional construct associated with acting without foresight, inefficient inhibitory response control, and alterations in reward processing. On an empirical level, relationships and... Read More about A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.

Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents (2021)
Journal Article
Ottino-González, J., Albaugh, M. D., Cao, Z., Cupertino, R. B., Schwab, N., Spechler, P. A., …Garavan, H. (2022). Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction, 117(5), 1312-1325. https://doi.org/10.1111/add.15772

BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults wi... Read More about Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., …Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Global urbanicity is associated with brain and behaviour in young people (2021)
Journal Article
Xu, J., Liu, X., Li, Q., Goldblatt, R., Qin, W., Liu, F., …Schumann, G. (2022). Global urbanicity is associated with brain and behaviour in young people. Nature Human Behaviour, 6(2), 279-293. https://doi.org/10.1038/s41562-021-01204-7

Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867).... Read More about Global urbanicity is associated with brain and behaviour in young people.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., …Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model (2021)
Journal Article
Penninck, L., Ibrahim, E. C., Artiges, E., Gorgievski, V., Desrivières, S., Farley, S., …Martinot, J. (2021). Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model. Frontiers in Systems Neuroscience, 15, 1-14. https://doi.org/10.3389/fnsys.2021.725413

Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to pl... Read More about Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation (2021)
Journal Article
Elkrief, L., Lin, B., Marchi, M., Afzali, M. H., Banaschewski, T., Bokde, A. L. W., …Consortium, I. (2023). Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation. Psychological Medicine, 53(5), 1759-1769. https://doi.org/10.1017/s0033291721003378

Background It has not yet been determined if the commonly reported cannabis–psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders. Methods We examined whether the relationship between polygenic ri... Read More about Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Similarity and stability of face network across populations and throughout adolescence and adulthood (2021)
Journal Article
Liao, Z., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., …Paus, T. (2021). Similarity and stability of face network across populations and throughout adolescence and adulthood. NeuroImage, 244, Article 118587. https://doi.org/10.1016/j.neuroimage.2021.118587

The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-var... Read More about Similarity and stability of face network across populations and throughout adolescence and adulthood.

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article
Jewell, A., Williams, H., Hoad, C. L., Gellert, P. R., Ashford, M. B., Butler, J., …Gershkovich, P. (2021). Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients. Pharmaceutics, 13(9), Article 1343. https://doi.org/10.3390/pharmaceutics13091343

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.