Skip to main content

Research Repository

Advanced Search

All Outputs (47)

Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong (2018)
Journal Article
Alzola, R., Easter, C., Riggs, C., Gardner, D., & Freeman, S. (2018). Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong. Equine Veterinary Journal, 50(5), 602-608. https://doi.org/10.1111/evj.12810

Background: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. Objectives: To determi... Read More about Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong.

Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability (2017)
Journal Article
Alzola Domingo, R., Riggs, C. M., Gardner, D. S., & Freeman, S. (2017). Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability. Veterinary Record, 181(24), https://doi.org/10.1136/vr.104233

Superficial digital flexor tendon (SDFT) tendinopathy is an important musculoskeletal problem in horses. The study objective was to validate an ultrasonographic scoring system for SDFT injuries. Ultrasonographic images from 14 Thoroughbred racehorses... Read More about Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability.

Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines (2017)
Journal Article
Davies, M., Alborough, R., Jones, L., Davis, C., Williams, C., & Gardner, D. S. (2017). Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines. Scientific Reports, 7(1), 1-9. https://doi.org/10.1038/s41598-017-17159-7

© 2017 The Author(s). Mineral content of complete pet food is regulated to ensure health of the companion animal population. Analysis of adherence to these regulatory guidelines has not been conducted. Here, mineral composition of complete wet (n = 9... Read More about Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines.

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, Article 15685. https://doi.org/10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.

Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies (2017)
Journal Article
Ruiz-Diaz, M. D., Partridge, H., Davidson, F., Mongan, N. P., Gardner, D. S., & Rutland, C. S. (2017). Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies. European Medical Journal Reproductive Health, 3(1),

It is well known that consumption of a balanced diet throughout adulthood is key toward maintenance of optimal body weight and cardiovascular health. Research using animal models can provide insights into the programming of short and long-term health... Read More about Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies.

Tissue cell stress response to obesity and its interaction with late gestational diet (2017)
Journal Article
Saroha, V., Dellschaft, N. S., Keisler, D. H., Gardner, D. S., Budge, H., Sebert, S. P., & Symonds, M. E. (2018). Tissue cell stress response to obesity and its interaction with late gestational diet. Reproduction, Fertility and Development, 30, https://doi.org/10.1071/RD16494

Intra-uterine growth restriction in late pregnancy can contribute to adverse long term metabolic health in the offspring. We utilised an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring... Read More about Tissue cell stress response to obesity and its interaction with late gestational diet.

The detection of great crested newts year round via environmental DNA analysis (2017)
Journal Article
Rees, H. C., Baker, C. A., Gardner, D. S., Maddison, B. C., & Gough, K. C. (2017). The detection of great crested newts year round via environmental DNA analysis. BMC Research Notes, 10(1), Article 327. https://doi.org/10.1186/s13104-017-2657-y

Objective Analysis of environmental DNA (eDNA) is a method that has been used for the detection of various species within water bodies. The great crested newt (Triturus cristatus) has a short eDNA survey season (mid-April to June). Here we investi... Read More about The detection of great crested newts year round via environmental DNA analysis.

Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China (2017)
Journal Article
Tian, A., Li, G., Elsheikha, H. M., Gardner, D., Zhang, X., Dong, W., …Zhu, X. (2017). Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China. Epidemiology and Infection, 145(11), 2296-2302. https://doi.org/10.1017/S0950268817001327

The role of the protozoan parasite Toxoplasma gondii in the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated with T. gondii infection in patients with l... Read More about Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China.

Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs (2017)
Journal Article
Adamany, J. L., Cross, G. F., Gardner, D., & Dunning, M. D. (2017). Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs. Journal of Small Animal Practice, 58(7), 403-407. doi:10.1111/jsap.12675

Objectives The influence of glucocorticoid therapy on bone resorption in dogs using a urine N?telopeptide assay was investigated. Materials and Methods Thirty?one dogs receiving oral glucocorticoids and 31 age?matched healthy control dogs were e... Read More about Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs.

Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry (2017)
Journal Article
Davies, M., West, J., Williams, C., & Gardner, D. S. (in press). Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry. Veterinary Record, 180(18), https://doi.org/10.1136/vr.103953

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs... Read More about Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry.

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More about Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism (2017)
Journal Article
Welham, S. J., Sparrow, A. J., Gardner, D. S., & Elmes, M. J. (2017). Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism. World Journal of Nephrology, 6(1), https://doi.org/10.5527/WJN.v6.i1.21

AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development. METHODS: Pairs of fetal mouse kidneys at embryonic day 12.5 were cultured... Read More about Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism.

Healthy ageing of cloned sheep (2016)
Journal Article
Sinclair, K. D., Corr, S., Gutierrez, C. G., Fisher, P., Lee, J., Rathbone, A., …Gardner, D. (2016). Healthy ageing of cloned sheep. Nature Communications, 7, 1-10. https://doi.org/10.1038/ncomms12359

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detri... Read More about Healthy ageing of cloned sheep.

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article
Sinclair, K. D., Rutherford, K., Wallace, J., Brameld, J., Stöger, R., Alberio, R., …Dwyer, C. (in press). Epigenetics and developmental programming of welfare and production traits in farm animals. Reproduction, Fertility and Development, 28(10), https://doi.org/10.1071/RD16102

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., …Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring (2015)
Journal Article
Gardiner, S. M., Gardner, D. S., Elmes, M., & Gray, C. (2016). Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring. British Journal of Nutrition, 115(4), 594-604. https://doi.org/10.1017/S0007114515004936

© Copyright 2015 The Authors. The Western diet is typically high in salt and fructose, which have pressor activity. Maternal diet can affect offspring blood pressure, but the extent to which maternal intake of excess salt and fructose may influence c... Read More about Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring.

Micronutrient and amino acid losses in acute renal replacement therapy (2015)
Journal Article
Oh, W. C., Gardner, D. S., & Devonald, M. A. (2015). Micronutrient and amino acid losses in acute renal replacement therapy. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), 593-598. https://doi.org/10.1097/MCO.0000000000000220

A wide range of renal replacement therapies is now available to support patients with acute kidney injury. These treatments utilize diffusion, convection or a combination of these mechanisms to remove metabolic waste products from the bloodstream. It... Read More about Micronutrient and amino acid losses in acute renal replacement therapy.

Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring (2015)
Journal Article
Dellschaft, N. S., Alexandre-Gouabau, M., Gardner, D. S., Antignac, J., Keisler, D. H., Budge, H., …Sebert, S. P. (2015). Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. Journal of Endocrinology, 224(2), https://doi.org/10.1530/JOE-14-0600

Maternal caloric restriction during late gestation reduces birth weight, but whether long-term adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic env... Read More about Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.

Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs (2014)
Journal Article
Naqid, I. A., Owen, J. P., Maddison, B. C., Gardner, D. S., Foster, N., Tchorzewska, M., …Gough, K. C. (2015). Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs. Animal Feed Science and Technology, 201, 57-65. https://doi.org/10.1016/j.anifeedsci.2014.12.005

Salmonellosis causes significant economic losses to the pig industry and contaminated pork products are an important source of Salmonella for humans. The EU ban on the use of antibiotic growth promoters in pig production, and the emergence of antibio... Read More about Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs.