All Outputs (63)

Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form (2019)
Journal Article
Cader, H. K., Rance, G. A., Alexander, M. R., Gonçalves, A. D., Roberts, C. J., Tuck, C. J., & Wildman, R. D. (2019). Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form. International Journal of Pharmaceutics, 564, 359-368. https://doi.org/10.1016/j.ijpharm.2019.04.026

Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, i... Read More about Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form.

Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC) (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC). AAPS PharmSciTech, 20(3), https://doi.org/10.1208/s12249-019-1346-7

Surface - modified nanostructured lipid carriers (NLC) is a promising formulation to prolong the retention time of the therapeutic agent at the site of absorption. Chitosan-coated AmpB-loaded NLC (ChiAmpB NLC) were developed showing particle size of... Read More about Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC).

Lipids and polymers in pharmaceutical technology: lifelong companions (2019)
Journal Article
Siepmann, J., Faham, A., Clas, S., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., …Leroux, J. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, st... Read More about Lipids and polymers in pharmaceutical technology: lifelong companions.

Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry (2019)
Journal Article
Tiddia, M., Mihara, I., Seah, M. P., Trindade, G. F., Kollmer, F., Roberts, C. J., …Havelund, R. (2019). Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry. ACS Applied Materials and Interfaces, 11(4), 4500-4506. https://doi.org/10.1021/acsami.8b15091

Copyright © 2019 American Chemical Society. Organic-inorganic hybrid materials enable the design and fabrication of new materials with enhanced properties. The interface between the organic and inorganic materials is often critical to the device's pe... Read More about Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry.

Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine (2018)
Journal Article
Ali, J., Zgair, A., Hameed, G. S., Garnett, M. C., Roberts, C. J., Burley, J. C., & Gershkovich, P. (2019). Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine. International Journal of Pharmaceutics, 555, 228-236. https://doi.org/10.1016/j.ijpharm.2018.11.051

The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution assessment of... Read More about Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine.

Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B (2018)
Journal Article
Tan Sui Ling, J., Roberts, C., & Billa, N. (2018). Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B. Pharmaceutical Development and Technology, 24(4), 504-512. https://doi.org/10.1080/10837450.2018.1515225

This study describes the properties of an amphotericin B-containing mucoadhesive nanostructured lipid carrier (NLC), with the intent to maximize uptake within the gastrointestinal tract. We have reported previously that lipid nanoparticles can signif... Read More about Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B.

Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Irvine, D. J., Wildman, R. D., Wallace, M. J., Sharpe, S., …Roberts, C. J. (2018). Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech, 19(8), 3403–3413. https://doi.org/10.1208/s12249-018-1107-z

An extrusion based 3D printer was used to fabricate paracetamol tablets with different geometries (mesh, ring, and solid) from a single paste-based formulation formed from standard pharmaceutical ingredients. The tablets demonstrate that tunable drug... Read More about Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry.

Using total specific cost indices to compare the cost performance of additive manufacturing for the medical devices domain (2018)
Journal Article
Baumers, M., Wildman, R., Wallace, M., Yoo, J., Blackwell, B., Farr, P., & Roberts, C. J. (2018). Using total specific cost indices to compare the cost performance of additive manufacturing for the medical devices domain. Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, 1-15. https://doi.org/10.1177/0954405418774591

The label additive manufacturing, also known as three-dimensional printing, serves as an umbrella term for a number of technologies designed to deposit product geometries directly from build materials and digital design information. However, as a rel... Read More about Using total specific cost indices to compare the cost performance of additive manufacturing for the medical devices domain.

The role of dipole interactions in hyperthermia heating colloidal clusters of densely-packed superparamagnetic nanoparticles (2018)
Journal Article
Fu, R., Yan, Y., Roberts, C., Liu, Z., & Chen, Y. (in press). The role of dipole interactions in hyperthermia heating colloidal clusters of densely-packed superparamagnetic nanoparticles. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-23225-5

This work aims to investigate the influence of inter-particle dipole interactions on hyperthermia heating colloidal clusters of densely-packed Fe3O4 nanoparticles at low field intensity. Emulsion droplet solvent evaporation method was used to assembl... Read More about The role of dipole interactions in hyperthermia heating colloidal clusters of densely-packed superparamagnetic nanoparticles.

Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability (2018)
Journal Article
Fridgeirsdottir, G., Harris, R., Dryden, I. L., Fischer, P. M., & Roberts, C. J. (2018). Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability. Molecular Pharmaceutics, 15(5), https://doi.org/10.1021/acs.molpharmaceut.8b00021

Solid dispersions can be a successful way to enhance the bioavailability of poorly soluble drugs. Here 60 solid dispersion formulations were produced using ten chemically diverse, neutral, poorly soluble drugs, three commonly used polymers, and two m... Read More about Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability.

The application of X-ray micro Computed Tomography imaging for tracing particle movement in soil (2018)
Journal Article
Grayling, K., Young, S. D., Roberts, C. J., de Heer, M. I., Shirley, I., Sturrock, C., & Mooney, S. J. (2018). The application of X-ray micro Computed Tomography imaging for tracing particle movement in soil. Geoderma, 321, https://doi.org/10.1016/j.geoderma.2018.01.038

Despite significant advances in recent years in the application of sensing and imaging technologies to the study of the hydraulic behaviour of soils, our understanding of how solutes and particulate matter move through soil is still limited and often... Read More about The application of X-ray micro Computed Tomography imaging for tracing particle movement in soil.

3D extrusion printing of high drug loading immediate release paracetamol tablets (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Wildman, R. D., Wallace, M. J., Sharpe, S., Yoo, J., & Roberts, C. J. (2018). 3D extrusion printing of high drug loading immediate release paracetamol tablets. International Journal of Pharmaceutics, 538(1-2), 223-230. https://doi.org/10.1016/j.ijpharm.2018.01.024

The manufacture of immediate release high drug loading paracetamol oral tablets was achieved using an extrusion based 3D printer from a premixed water based paste formulation. The 3D printed tablets demonstrate that a very high drug (paracetamol) loa... Read More about 3D extrusion printing of high drug loading immediate release paracetamol tablets.

Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery (2018)
Journal Article
Louzao, I., Koch, B., Taresco, V., Ruiz Cantu, L., Irvine, D. J., Roberts, C. J., …Alexander, M. R. (in press). Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery. ACS Applied Materials and Interfaces, 10(8), https://doi.org/10.1021/acsami.7b15677

A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this me... Read More about Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery.

An augmented delivery of the anticancer agent, curcumin, to the colon (2017)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2018). An augmented delivery of the anticancer agent, curcumin, to the colon. Reactive and Functional Polymers, 123, https://doi.org/10.1016/j.reactfunctpolym.2017.12.012

This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a gal... Read More about An augmented delivery of the anticancer agent, curcumin, to the colon.

3D printing of tablets using inkjet with UV photoinitiation (2017)
Journal Article
Clark, E. A., Alexander, M. R., Irvine, D. J., Roberts, C. J., Wallace, M. J., Sharpe, S., …Wildman, R. D. (2017). 3D printing of tablets using inkjet with UV photoinitiation. International Journal of Pharmaceutics, 529(1-2), 523-530. https://doi.org/10.1016/j.ijpharm.2017.06.085

Additive manufacturing (AM) offers significant potential benefits in the field of drug delivery and pharmaceutical/medical device manufacture. Of AM processes, 3D inkjet printing enables precise deposition of a formulation, whilst offering the potent... Read More about 3D printing of tablets using inkjet with UV photoinitiation.

3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release (2017)
Journal Article
Kyobula, M., Adedeji, A., Alexander, M. R., Saleh, E., Wildman, R. D., Ashcroft, I., …Roberts, C. J. (2017). 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release. Journal of Controlled Release, 261, 207-215. https://doi.org/10.1016/j.jconrel.2017.06.025

A hot melt 3D inkjet printing method with the potential to manufacture formulations in complex and adaptable geometries for the controlled loading and release of medicines is presented. This first use of a precisely controlled solvent free inkjet pri... Read More about 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release.

Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release (2017)
Journal Article
Siddiqui, N. A., Billa, N., & Roberts, C. J. (in press). Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release. Journal of Biomaterials Science, Polymer Edition, 28(8), https://doi.org/10.1080/09205063.2017.1301774

The principal challenge for the use of boronic acids (BA) as glucose sensors is their lack of specificity for glucose. We examined the selectivity of and insulin release from two boronic acids- (2-formyl-3-thienylboronic acid (FTBA) and 4-formylpheny... Read More about Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release.

Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis (2017)
Journal Article
Dereymaker, A., Scurr, D. J., Steer, E. D., Roberts, C. J., & Van den Mooter, G. (2017). Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis. Molecular Pharmaceutics, 14(4), 959-973. https://doi.org/10.1021/acs.molpharmaceut.6b01023

Fluid bed coating has been shown to be a suitable manufacturing technique to formulate poorly soluble drugs in glass solutions. Layering inert carriers with a drug–polymer mixture enables these beads to be immediately filled into capsules, thus avoid... Read More about Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis.

Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry (2016)
Journal Article
Amekyeh, H., Billa, N., & Roberts, C. J. (2017). Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry. International Journal of Pharmaceutics, 517(1-2), https://doi.org/10.1016/j.ijpharm.2016.12.001

Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used... Read More about Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry.

Disruption of diphenylalanine assembly by a Boc-modified variant (2016)
Journal Article
Creasey, R., Louzao, I., Arnon, Z., Marco, P., Adler-Abramovich, L., Roberts, C. J., …Tendler, S. J. (2016). Disruption of diphenylalanine assembly by a Boc-modified variant. Soft Matter, 12(47), 9451-9457. https://doi.org/10.1039/c6sm01770c

Peptide-based biomaterials are key to the future of diagnostics and therapy, promoting applications such as tissue scaffolds and drug delivery vehicles. To realise the full potential of the peptide systems, control and optimisation of material proper... Read More about Disruption of diphenylalanine assembly by a Boc-modified variant.