Research Repository

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MeMa: Designing the Memory Machine (2019)
Conference Proceeding
Price, D., Jacobs, R., Darzentas, D., Perez Vallejos, E., Chadborn, N., Martindale, S., & Urquhart, L. (2019). MeMa: Designing the Memory Machine. In Companion Publication of the 2019 on Designing Interactive Systems Conference 2019 Companion, 271--276. doi:10.1145/3301019.3323882

The Memory Machine is an ambitious project that aims to develop a device to capture people's memories to create a blend of personal and factual data that builds identities, and contextualizes personal recollections. The Memory Machine has been guided... Read More

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., …Sprigg, N. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men (2019)
Journal Article
Gharahdaghi, N., Rudrappa, S., Brook, M. S., Idris, I., Crossland, H., Hamrock, C., …Atherton, P. J. (2019). Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men. Journal of Cachexia, Sarcopenia and Muscle, https://doi.org/10.1002/jcsm.12472

Background: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia) and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RE... Read More

Determinants of change in Arterial Stiffness over 5 years in Early Chronic Kidney Disease (2019)
Journal Article
Mcintyre, N., Shardlow, A., Fluck, R., Mcintyre, C., & Taal, M. (2019). Determinants of change in Arterial Stiffness over 5 years in Early Chronic Kidney Disease. Nephrology Dialysis Transplantation, https://doi.org/10.1093/ndt/gfz170

Background Arterial stiffness is an established and potentially modifiable risk factor for cardiovascular disease, associated with chronic kidney disease. There have been few studies to evaluate progression of arterial stiffness over time or factors... Read More

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article
Viramontes Horner, D., & Taal, M. W. (2019). Skin autofluorescence: an emerging biomarker in persons with kidney disease. Current Opinion in Nephrology and Hypertension, 28(6), 507–512. https://doi.org/10.1097/MNH.0000000000000549

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article
Delanaye, P., Jager, K. J., Bökenkamp, A., Christensson, A., Dubourg, L., Eriksen, B. O., …van den Brand, J. A. (2019). Chronic Kidney Disease: call for an age-adapted definition. Journal of the American Society of Nephrology, 30(9), https://doi.org/10.1681/ASN.2019030238

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More

Effectiveness of exercise interventions for adults over 65 with moderate-to-severe dementia in community settings: a systematic review (2019)
Journal Article
Long, A., Robinson, K., Goldberg, S., & Gordon, A. L. (2019). Effectiveness of exercise interventions for adults over 65 with moderate-to-severe dementia in community settings: a systematic review. European Geriatric Medicine, https://doi.org/10.1007/s41999-019-00236-7

Purpose To conduct a systematic review of the literature to evaluate the effectiveness of exercise interventions for people with moderate-to-severe dementia in community settings. Methods Eight electronic databases (MEDLINE, Embase, CINAHL, AMED... Read More

Early-Stage Breast Cancer in Older Adults (2019)
Book Chapter
Cheung, K., Livi, L., & Brain, E. (2019). Early-Stage Breast Cancer in Older Adults. In M. Extermann (Ed.), Geriatric Oncology, 1-10. Springer. doi:10.1007/978-3-319-44870-1_33-1

Breast cancer is the most common cancer afflicting women worldwide. Its incidence peaks around 70, while mortality increases greatly after 75 years old. Given the competing risks on mortality with multimorbidities, geriatric assessment is a leitmotiv... Read More

Effect of bariatric surgery on cardiovascular events and metabolic outcomes in obese patients with insulin-treated type 2 diabetes: a retrospective cohort study (2019)
Journal Article
Alkharaiji, M., Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Effect of bariatric surgery on cardiovascular events and metabolic outcomes in obese patients with insulin-treated type 2 diabetes: a retrospective cohort study. Obesity Surgery, doi:10.1007/s11695-019-03809-4

Aims: To compare non-fatal cardiovascular (CV) events and metabolic outcomes, among obese patients with insulin-treated type 2 diabetes who underwent bariatric surgery compared to a propensity matched non-bariatric cohort. Methods: A retrospective... Read More

Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients (2019)
Journal Article
Thomas, P. W., Blackwell, J. E. M., Herrod, P. J. J., Peacock, O., Singh, R., Williams, J. P., …Lund, J. N. (2019). Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients. Techniques in Coloproctology, 1-7. doi:10.1007/s10151-019-02056-0

Background Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for reconstruction include mesh... Read More

A statistical and biological response to an informatics appraisal of healthy aging gene signatures (2019)
Journal Article
Timmons, J. A., Gallagher, I. J., Sood, S., Phillips, B., Crossland, H., Howard, R., …Atherton, P. J. (2019). A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20(1), 1-4. doi:10.1186/s13059-019-1734-z

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. Read More

The impact of uterine artery embolization on ovarian reserve: a systematic review and meta‐analysis (2019)
Journal Article
El Shamy, T., Amer, S., Mohamed, A., James, C., & Jayaprakasan, K. (2019). The impact of uterine artery embolization on ovarian reserve: a systematic review and meta‐analysis. Acta Obstetricia et Gynecologica Scandinavica, doi:10.1111/aogs.13698

Introduction: In the recent years, uterine artery embolisation (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been a growing concern over the risk of unintended e... Read More