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The efficacy of statins as otoprotective agents: A systematic review (2019)
Journal Article
Prayuenyong, P., Kasbekar, A. V., & Baguley, D. M. (in press). The efficacy of statins as otoprotective agents: A systematic review. Clinical Otolaryngology,

Objective: This systematic review examined the current literature, summarized research findings and identified research gaps regarding the efficacy of statins on audiological outcomes. Methods: Systematic search of electronic databases and grey l... Read More

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., …Sprigg, N. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More

Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging (2019)
Journal Article
Chou, I., Tanasescu, R., Mougin, O. E., Gowland, P. A., Tench, C. R., Whitehouse, W. P., …Constantinescu, C. S. (2019). Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-50928-0

Whether the integrity of normal-appearing white matter (NAWM) is preserved in neuromyelitis optica spectrum disorders (NMOSD) is open to debate. To examine whether the tissue integrity of NAWM in NMOSD is compromised compared to that in healthy contr... Read More

Mathematical and Computational Modelling in Critical Illness (2019)
Journal Article
Laviola, M., Bates, D. G., & Hardman, J. G. (2019). Mathematical and Computational Modelling in Critical Illness. European Respiratory & Pulmonary Diseases, 5(1),

Mathematical and computational modelling are assuming a prominent role in investigating the complex pathophysiological states and therapeutic strategies in critical illness. This editorial briefly illustrates the models of the respiratory and cardiov... Read More

On the interaction of head and gaze control with acoustic beam width of a simulated beamformer in a two-talker scenario (2019)
Journal Article
Hládek, Ľ., Porr, B., Naylor, G., Lunner, T., & Owen Brimijoin, W. (2019). On the interaction of head and gaze control with acoustic beam width of a simulated beamformer in a two-talker scenario. Trends in Hearing, 23, 1-12. https://doi.org/10.1177/2331216519876795

Superdirectional acoustic beamforming technology provides a high signal-to-noise ratio, but potential speech intelligibility benefits to hearing aid users are limited by the way the users move their heads. Steering the beamformer using eye gaze inste... Read More

Noncontrast CT signs as predictors of hematoma expansion, clinical outcome and response to tranexamic acid in acute ICH (2019)
Journal Article
Law, Z. K., Ali, A., Krishnan, K., Bischoff, A., Appleton, J., Scutt, P., …Sprigg, N. (in press). Noncontrast CT signs as predictors of hematoma expansion, clinical outcome and response to tranexamic acid in acute ICH. Stroke,

Background and purpose Blend, black hole and island signs and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage (ICH). We explored the value of these noncontrast CT (NCCT) signs in predicting hematoma expan... Read More

Understanding user reactions and interactions with an Internet-based intervention for tinnitus self-management: Mixed-methods evaluation (2019)
Journal Article
Greenwell, K., Sereda, M., Coulson, N. S., & Hoare, D. J. (2019). Understanding user reactions and interactions with an Internet-based intervention for tinnitus self-management: Mixed-methods evaluation. American Journal of Audiology, 28(3), 697-713. https://doi.org/10.1044/2019_AJA-18-0171

Purpose: Internet-based interventions have the potential to reduce the disparity in access to psychological therapy that people with tinnitus currently experience. One example is the Tinnitus E-Programme, which although freely available online, has n... Read More

Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization (2019)
Journal Article
Brainin, M., Feigin, V., Bath, P. M., Collantes, E., Martins, S., Pandian, J., …Teuschl, Y. (2019). Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization. International Journal of Stroke, https://doi.org/10.1177/1747493019873706

The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries... Read More

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article
Marsit, N. M., Sidney, L. E., Britchford, E. R., McIntosh, O. D., Allen, C. L., Ashraf, W., …Hopkinson, A. (2019). Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane. Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49314-7

Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children (2019)
Journal Article
Bagatto, M., DesGeorge, J., Kitterick, P., Laurnagaray, D., Roush, P., Sladen, D., & Tharpe, A. (2019). Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children. International Journal of Audiology, https://doi.org/10.1080/14992027.2019.1654620

Objective: Provide recommendations to audiologists for the management of children with unilateral hearing loss (UHL) and for needed research that can lend further insight on important unanswered questions. Design: An international panel of experts... Read More

Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke (2019)
Journal Article
Appleton, J. P., Woodhouse, L. J., Adami, A., Becker, J. L., Berge, E., Cala, L. A., …Wardlaw, J. M. (in press). Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke. Neurology,

Objective: We assessed the association of baseline imaging markers of cerebral small vessel disease (SVD) and ‘brain frailty’ with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods: ENOS randomis... Read More

Mechanisms and risk factors contributing to visual field deficits following stereotactic laser amygdalohippocampotomy (2019)
Journal Article
Voets, N. L., Alvarez, I., Qiu, D., Leatherday, C., Willie, J. T., Sotiropoulos, S., …Drane, D. L. (in press). Mechanisms and risk factors contributing to visual field deficits following stereotactic laser amygdalohippocampotomy. Stereotactic and Functional Neurosurgery, https://doi.org/10.1159/000502701

Selective laser amygdalohippocampotomy (SLAH) is a minimally invasive surgical treatment for medial temporal lobe epilepsy. Visual field deficits (VFDs) are a significant potential complication. The objective of this study was to determine the relati... Read More

Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936 (2019)
Journal Article
Okely, J. A., Akeroyd, M. A., Allerhand, M., Starr, J. M., & Deary, I. J. (2019). Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936. Psychology and Aging, doi:10.1037/pag0000385

Hearing impairment is associated with poorer cognitive function in later life. We tested for the potential contribution of childhood cognitive ability to this relationship. Childhood cognitive ability is strongly related to cognitive function in olde... Read More

Why Is There No Cure for Tinnitus? (2019)
Journal Article
McFerran, D. J., Stockdale, D., Holme, R., Large, C. H., & Baguley, D. M. (2019). Why Is There No Cure for Tinnitus?. Frontiers in Neuroscience, 13, doi:10.3389/fnins.2019.00802

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended... Read More