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Pharmacokinetics and Tissue Distribution of an Orally Administered Mucoadhesive Chitosan-Coated 1 Amphotericin B-Loaded Nanostructured Lipid Carrier (NLC) in Rats (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Pharmacokinetics and Tissue Distribution of an Orally Administered Mucoadhesive Chitosan-Coated 1 Amphotericin B-Loaded Nanostructured Lipid Carrier (NLC) in Rats. Journal of Biomaterials Science, Polymer Edition, https://doi.org/10.1080/09205063.2019.1680926

Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed AmpB formulations. The goal of the study was to investigate the p... Read More

Identifying 'avoidable harm' in family practice: a RAND/UCLA Appropriateness Method consensus study (2019)
Journal Article
Carson-Stevens, A., Campbell, S., Cooper, A., Armstrong, S., Ashcroft, D., Boyd, M., …Avery, A. (2019). Identifying 'avoidable harm' in family practice: a RAND/UCLA Appropriateness Method consensus study. BMC Family Practice, 20, https://doi.org/10.1186/s12875-019-0990-z

Background: Health care-related harm is an internationally recognized threat to public health. The United Kingdom’s national health services demonstrate that upwards of 90% of health care encounters can be delivered in ambulatory settings. Other coun... Read More

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (in press). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology,

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More

NanoBiT ® Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization (2019)
Journal Article
Soave, M., Kellam, B., Woolard, J., Briddon, S. J., & Hill, S. J. (2019). NanoBiT ® Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization. Slas Discovery, https://doi.org/10.1177/2472555219880475

Receptor internalization in response to prolonged agonist treatment is an important regulator of G protein–coupled receptor (GPCR) function. The adenosine A1 receptor (A1AR) is one of the adenosine receptor family of GPCRs, and evidence for its agoni... Read More

Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation (2019)
Journal Article
Dundas, A. A., Sanni, O., Dubern, J., Dimitrakis, G., Hook, A. L., Irvine, D. J., …Alexander, M. R. (2019). Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation. Advanced Materials, https://doi.org/10.1002/adma.201903513

ynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day o... Read More

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor (2019)
Journal Article
Fyfe, T. J., Kellam, B., Sykes, D. A., Capuano, B., Scammells, P. J., Lane, J. R., …Mistry, S. N. (2019). Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.9b00864

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with c... Read More

Protein encapsulation of experimental anticancer agents 5F 203 and Phortress: towards precision drug delivery (2019)
Journal Article
Breen, A. F., Scurr, D., Cassioli, M. L., Wells, G., Thomas, N. R., Zhang, J., …Bradshaw, T. D. (in press). Protein encapsulation of experimental anticancer agents 5F 203 and Phortress: towards precision drug delivery. International Journal of Nanomedicine,

Introduction: Advancment of novel anticancer drugs into clinic is frequently halted by their lack of solubility, reduced stability under physiological conditions, and non-specific uptake by normal tissues, causing systemic toxicity. Their progress to... Read More

Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells (2019)
Journal Article
Tatic, N., Rose, F. R., des Rieux, A., & White, L. J. (2019). Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-50367-x

After spinal cord injury (SCI) chronic inflammation hampers regeneration. Influencing the local microenvironment after SCI may provide a strategy to modulate inflammation and the immune response. The objectives of this work were to determine whether... Read More

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer (2019)
Journal Article
Garces, A. E., Al-Hayali, M., Lee, J. B., Li, J., Gershkovich, P., Bradshaw, T. D., & Stocks, M. J. (2019). Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer. ACS Medicinal Chemistry Letters, https://doi.org/10.1021/acsmedchemlett.9b00378

We report on the synergistic effect of PI3K inhibition with ALK inhibition for the possible treatment of EML4-ALK positive lung cancer. We have brought together ceritinib (ALK inhibitor) and pictilisib (PI3K inhibitor) into a single bivalent molecule... Read More

Ant colony optimisation for community pharmacy dispensing process based on in-field observations (2019)
Conference Proceeding
Naybour, M., Remenyte-Prescott, R., & Boyd, M. (2019). Ant colony optimisation for community pharmacy dispensing process based on in-field observations. In M. Beer, & E. Zio (Eds.), Proceedings of the 29th European Safety and Reliability Conference (ESREL 2019)

The community pharmacy dispensing process is an integral part of delivering effective primary care to patients around the world. However, dispensing error rates and related patient safety issues are always a concern in the sector, where studies have... Read More

Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update (2019)
Journal Article
Swainson, S. M., Styliari, I. D., Taresco, V., & Garnett, M. C. (2019). Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers, 11(10), 1561. https://doi.org/10.3390/polym11101561

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad field of drug delivery. The step-growth po... Read More

Quantification of energy of activation to supramolecular nanofibre formation reveals enthalpic and entropic effects and morphological consequence (2019)
Journal Article
Samperi, M., Perez-Garcia, L., & Amabilino, D. B. (2019). Quantification of energy of activation to supramolecular nanofibre formation reveals enthalpic and entropic effects and morphological consequence. Chemical Science, https://doi.org/10.1039/c9sc03280k

We show a self-assembly process leading to fibres from a system that starts far from equilibrium because of fast solvent – anti-solvent mixing and analyse the activation energies associated with the aggregation. It is in some ways reminiscent of dive... Read More

The ‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow up of a pragmatic randomised controlled trial (2019)
Journal Article
Elliott, R. A., Boyd, M., Tanajewski, L., Barber, N., Gkountouras, G., Avery, A. J., …Chuter, A. (in press). The ‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow up of a pragmatic randomised controlled trial. BMJ Quality and Safety,

A comparison of six osteoporosis risk assessment tools among postmenopausal women in Kuala Lumpur, Malaysia (2019)
Journal Article
Shean Toh, L., Lai, P. S. M., Wu, D. B., Bell, B. G., Dang, C. P. L., Low, B. Y., …Anderson, C. (2019). A comparison of six osteoporosis risk assessment tools among postmenopausal women in Kuala Lumpur, Malaysia. Osteoporosis and Sarcopenia, https://doi.org/10.1016/j.afos.2019.09.001

Objectives To compare and assess the performance of 6 osteoporosis risk assessment tools for screening osteoporosis in Malaysian postmenopausal women. Methods Six osteoporosis risk assessments tools (the Simple Calculated Osteoporosis Risk Estim... Read More

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells (2019)
Journal Article
Liu, Z., Turyanska, L., Zamberlan, F., Pacifico, S., Bradshaw, T. D., Moro, F., …Thomas, N. R. (2019). Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. Nanotechnology, 30(50), https://doi.org/10.1088/1361-6528/ab437c

We report on the synthesis of water-soluble gold nanoclusters capped with polyethylene glycol (PEG)-based ligands and further functionalized with folic acid for specific cellular uptake. The dihydrolipoic acid-PEG-based ligands terminated with -OMe,... Read More

Localized induction of gene expression in embryonic stem cell aggregates using holographic optical tweezers to create biochemical gradients (2019)
Journal Article
Kirkham, G. R., Ware, J., Upton, T., Allen, S., Shakesheff, K. M., & Buttery, L. D. (2019). Localized induction of gene expression in embryonic stem cell aggregates using holographic optical tweezers to create biochemical gradients. Regenerative Engineering and Translational Medicine, doi:10.1007/s40883-019-00114-5

Three dimensional (3D) cell models that mimic the structure and function of native tissues are enabling more detailed study of physiological and pathological mechanisms in vitro. We have previously demonstrated the ability to build and manipulate 3D... Read More

Crystal structure and substrate-induced activation of ADAMTS13 (2019)
Journal Article
Petri, A., Kim, H. J., Xu, Y., de Groot, R., Li, C., Vandenbulcke, A., …Crawley, J. T. (2019). Crystal structure and substrate-induced activation of ADAMTS13. Nature Communications, 10, doi:10.1038/s41467-019-11474-5

Platelet recruitment to sites of blood vessel damage is highly dependent upon von Willebrand factor (VWF). VWF platelet-tethering function is proteolytically regulated by the metalloprotease ADAMTS13. Proteolysis depends upon shear-induced conformati... Read More