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Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes (2024)
Journal Article
Meng, Y., Toledo-Rodriguez, M., Fedorenko, O. A., & Smith, P. A. (2024). Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes. Journal of Molecular Endocrinology, 72(4), Article e230108. https://doi.org/10.1530/JME-23-0108

White adipose tissue (WAT) requires extracellular Ca2+ influx for lipolysis, differentiation, and expansion. This partly occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). However, WFA exists in different depots whose function varies... Read More about Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes.

CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes (2019)
Journal Article
Fedorenko, O. A., Pulbutr, P., Banke, E., Akaniro-Ejim, N. E., Bentley, D. C., Olofsson, C. S., …Smith, P. A. (2020). CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes. Journal of Endocrinology, 244(2), 369–381. https://doi.org/10.1530/joe-19-0493

L-type channel antagonists are of therapeutic benefit in the treatment of hyperlipidaemia and insulin resistance. Our aim was to identify L-type voltage-gated Ca2+ channels in white fat adipocytes, and determine if they affect intracellular Ca2+, lip... Read More about CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes.

Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel (2019)
Journal Article
Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., Fedorenko, O. A., Roberts, S. K., & McClintock, P. V. E. (2019). Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel. Fluctuation and Noise Letters, 18(02), 1-13. https://doi.org/10.1142/s0219477519400078

The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aim... Read More about Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel.