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All Outputs (12)

Renal accumulation of prooxidant mineral elements and CKD in domestic cats (2020)
Journal Article
Alborough, R., Grau-Roma, L., de Brot, S., Hantke, G., Vazquez, S., & Gardner, D. S. (2020). Renal accumulation of prooxidant mineral elements and CKD in domestic cats. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-59876-6

Felids have a high incidence of chronic kidney disease (CKD), for which the most common renal lesion is chronic interstitial nephritis (CIN). CIN can be induced by tissue oxidative stress, which is determined by the cellular balance of pro- and anti-... Read More about Renal accumulation of prooxidant mineral elements and CKD in domestic cats.

A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma (2019)
Journal Article
de Brot, S., Grau-Roma, L., Stirling-Stainsby, C., Dettwiler, M., Guscetti, F., Meier, D., …Mongan, N. (2019). A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma. Journal of Comparative Pathology, 169, 35-46. https://doi.org/10.1016/j.jcpa.2019.04.003

Canine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly char... Read More about A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More about The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology.

Pulmonary basaloid squamous cell carcinoma in a dog (2018)
Journal Article
Morey-Matamalas, A., de Stefani, A., Corbetta, D., Grau-Roma, L., & de Brot, S. (2018). Pulmonary basaloid squamous cell carcinoma in a dog. Journal of Comparative Pathology, 159, https://doi.org/10.1016/j.jcpa.2017.12.007

A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the c... Read More about Pulmonary basaloid squamous cell carcinoma in a dog.

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics (2017)
Journal Article
Simpson, S., Dunning, M. D., de Brot, S., Grau-Roma, L., Mongan, N. P., & Rutland, C. S. (2017). Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59, Article 71. https://doi.org/10.1186/s13028-017-0341-9

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, o... Read More about Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.

Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat (2017)
Journal Article
Posporis, C., Grau-Roma, L., Travetti, O., Oliveira, M., Polledo, L., & Wessmann, A. (2017). Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat. Journal of Feline Medicine and Surgery Open Reports, 3(2), https://doi.org/10.1177/2055116917742812

A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3–L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7–T8 vertebra... Read More about Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat.

?-chloralose poisoning in a cat (2016)
Journal Article
Grau-Roma, L., Stephens, A., Wessmann, A., Carmichael, N., & de Brot, S. (2016). ?-chloralose poisoning in a cat. Vet Record Case Reports, 4(e00031), https://doi.org/10.1136/vetreccr-2016-000313

A five-year-old domestic cat with acute unexplainable neurological signs was presented for postmortem examination. Clinically, the cat showed an acute onset of ataxia, depressed mentation and continuous twitching/ seizure activity in the morning afte... Read More about ?-chloralose poisoning in a cat.

Six-year follow-up of slaughterhouse surveillance (2008-2013): the Catalan Slaughterhouse Support Network (SESC) (2016)
Journal Article
Vidal, E., Tolosa, E., Espinar, S., Pérez de Va, B., Nofrarías, M., Alba, A., …Domingo, M. (2016). Six-year follow-up of slaughterhouse surveillance (2008-2013): the Catalan Slaughterhouse Support Network (SESC). Veterinary Pathology, 53(3), https://doi.org/10.1177/0300985815593125

Meat inspection has the ultimate objective of declaring the meat and offal obtained from carcasses of slaughtered animals fit or unfit for human consumption. This safeguards the health of consumers by ensuring that the food coming from these establis... Read More about Six-year follow-up of slaughterhouse surveillance (2008-2013): the Catalan Slaughterhouse Support Network (SESC).

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., …Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes (2014)
Journal Article
Grau-Roma, L., Galindo-Cardiel, I., Isidoro-Ayza, M., Fernández, M., & Majó, N. (2014). A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes. Journal of Comparative Pathology, 151(4), https://doi.org/10.1016/j.jcpa.2014.08.005

Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineff... Read More about A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes.

Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins (2014)
Journal Article
Kurtz, S., Grau-Roma, L., Cortey, M., Fort, M., Rodríguez, F., Sibila, M., & Segalés, J. (2014). Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins. Veterinary Research, 45, Article 29. https://doi.org/10.1186/1297-9716-45-29

Porcine circovirus type 2 (PCV2) is the essential infectious agent for PCV2-systemic disease (PCV2-SD, formerly known as postweaning multisystemic wasting syndrome) and other pathological conditions. Recent studies indicated antigenic variability am... Read More about Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.