Research Repository

See what's under the surface


Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, doi:10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More

Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus (2018)
Journal Article
Said, D. G., Ross, A. R., Messina, M., Mohammed, I., & Dua, H. (2018). Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus. Eye, doi:10.1038/s41433-018-0211-3

Corneal collagen cross-linking (CXL) is the only treatment that delays or arrests progression of keratoconus. CXL is a safe procedure with few complications. CXL protocols vary depending on time and energy used but all are safe and effective. Variati... Read More

Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling (2018)
Journal Article
Mohammed, I., Ross, A. R., Britton, J. O., Said, D. G., & Dua, H. S. (2018). Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling. American Journal of Ophthalmology, 194, (16-25). doi:10.1016/j.ajo.2018.07.001. ISSN 0002-9394

Purpose Descemet membrane endothelial keratoplasty (DMEK) and pre-Descemet endothelial keratoplasty (PDEK) tissues always scroll with the endothelial cells (EC) outside. We designed a study to understand the reason for this behavior. Design... Read More

Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease (2018)
Journal Article
Song, D., Mohammed, I., Bhuyan, R., Miwa, T., Williams, A. L., Gullipalli, D., …Song, W. (2018). Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease. Investigative Ophthalmology & Visual Science, 59(8), (3405-3415). doi:10.1167/iovs.18-24133. ISSN 1552-5783

Purpose: Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). C... Read More

Nerve terminals at the human corneoscleral limbus (2017)
Journal Article
Al -Aqaba, M., Anis, F. S., Mohammed, I., & Dua, H. S. (2017). Nerve terminals at the human corneoscleral limbus. British Journal of Ophthalmology, 102(4), 556-561. doi:10.1136/bjophthalmol-2017-311146

Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus. Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age,... Read More

Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study (2017)
Journal Article
AlTaan, S., Mohammed, I., Said, D., & Dua, H. (2018). Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study. Eye, 32(1), 146-151. doi:10.1038/eye.2017.121

Purpose: To measure the pressure and volume of air required to create a big bubble (BB) in simulated deep anterior lamellar keratoplasty (DALK) in donor eyes and ascertain the bursting pressure of the BB. Patients and methods: Twenty-two human scler... Read More

Human antimicrobial peptides in ocular surface defense (2017)
Journal Article
Mohammed, I., Said, D. G., & Dua, H. S. (2017). Human antimicrobial peptides in ocular surface defense. Progress in Retinal and Eye Research, 61, (1-22). doi:10.1016/j.preteyeres.2017.03.004. ISSN 1350-9462

Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of... Read More

Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation (2017)
Journal Article
Ueda, Y., Mohammed, I., Song, D., Gullipalli, D., Zhou, L., Sato, S., …Song, W. (2017). Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood, 129(9), (1184-1196). doi:10.1182/blood-2016-07-728253. ISSN 0006-4971

Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the c... Read More

In vivo Magnetic Resonance Imaging of Tumor Protease Activity (2014)
Journal Article
Haris, M., Singh, A., Mohammed, I., Ittyerah, R., Nath, K., Nanga, R. P. R., …Reddy, R. (2015). In vivo Magnetic Resonance Imaging of Tumor Protease Activity. Scientific Reports, 4(1), doi:10.1038/srep06081

Increased expression of cathepsins has diagnostic as well as prognostic value in several types of cancer. Here, we demonstrate a novel magnetic resonance imaging (MRI) method, which uses poly-L-glutamate (PLG) as an MRI probe to map cathepsin express... Read More

In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis) (2014)
Journal Article
Dua, H. S., Otri, A. M., Hopkinson, A., & Mohammed, I. (2014). In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis). Transactions of the American Ophthalmological Society, 112, 50-73

Purpose: Human β-defensins (HBDs) are an important part of the innate immune host defense at the ocular surface. Unlike other defensins, expression of HBD9 at the ocular surface is reduced during microbial infection, but activation of toll-like recep... Read More

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article
Abedin, A., Mohammed, I., Hopkinson, A., & Dua, H. S. (2008). A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Investigative Ophthalmology & Visual Science, 49(1), (28-33). doi:10.1167/iovs.07-0645. ISSN 1552-5783

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More