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Developmental, cytogenetic and epigenetic consequences of removing complex proteins and adding melatonin during in vitro maturation of bovine oocytes (2023)
Journal Article
Tutt, D. A. R., Guven-Ates, G., Kwong, W. Y., Simmons, R., Sang, F., Silvestri, G., …Sinclair, K. D. (2023). Developmental, cytogenetic and epigenetic consequences of removing complex proteins and adding melatonin during in vitro maturation of bovine oocytes. Frontiers in Endocrinology, 14, Article 1280847. https://doi.org/10.3389/fendo.2023.1280847

Background: In vitro maturation (IVM) of germinal vesicle intact oocytes prior to in vitro fertilization (IVF) is practiced widely in animals. In human assisted reproduction it is generally reserved for fertility preservation or where ovarian stimula... Read More about Developmental, cytogenetic and epigenetic consequences of removing complex proteins and adding melatonin during in vitro maturation of bovine oocytes.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

Genome Reference Assembly for Bottlenecked Southern Australian Koalas (2022)
Journal Article
Blanchard, A. M., Emes, R. D., Greenwood, A. D., Holmes, N., Loose, M. W., McEwen, G. K., …Tarlinton, R. E. (2023). Genome Reference Assembly for Bottlenecked Southern Australian Koalas. Genome Biology and Evolution, 15(1), Article evac176. https://doi.org/10.1093/gbe/evac176

Koala populations show marked differences in inbreeding levels and in the presence or absence of the endogenous Koala retrovirus (KoRV). These genetic differences among populations may lead to severe disease impacts threatening koala population viabi... Read More about Genome Reference Assembly for Bottlenecked Southern Australian Koalas.

Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants (2022)
Journal Article
Stöger, R., Choi, M., Begum, K., Leeman, G., Emes, R. D., Melamed, P., & Bentley, G. R. (2023). Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants. Epigenetics, 18(1), Article 2153511. https://doi.org/10.1080/15592294.2022.2153511

Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) m... Read More about Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants.

Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs (2022)
Journal Article
Le Bon, M., Tötemeyer, S., Emes, R. D., & Mellits, K. H. (2022). Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs. Frontiers in Genetics, 13, Article 961474. https://doi.org/10.3389/fgene.2022.961474

Weaning represents one of the most critical periods in pig production associated with increase in disease risk, reduction in performance and economic loss. Physiological changes faced by piglets during the weaning period have been well characterised,... Read More about Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.

Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock (2022)
Journal Article
Maciel-Guerra, A., Baker, M., Hu, Y., Wang, W., Zhang, X., Rong, J., …Dottorini, T. (2023). Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. ISME Journal, 17, 21-35. https://doi.org/10.1038/s41396-022-01315-7

A debate is currently ongoing as to whether intensive livestock farms may constitute reservoirs of clinically relevant antimicrobial resistance (AMR), thus posing a threat to surrounding communities. Here, combining shotgun metagenome sequencing, mac... Read More about Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control (2022)
Journal Article
Baker, M., Williams, A. D., Hooton, S. P., Helliwell, R., King, E., Dodsworth, T., …Stekel, D. J. (2022). Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control. Environment International, 169, Article 107516. https://doi.org/10.1016/j.envint.2022.107516

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial res... Read More about Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control.

Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution (2022)
Journal Article
Tarlinton, R. E., Legione, A. R., Sarker, N., Fabijan, J., Meers, J., McMichael, L., …Emes, R. D. (2022). Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution. Journal of General Virology, 103(6), Article 001749. https://doi.org/10.1099/jgv.0.001749

Koala retrovirus (KoRV) is unique amongst endogenous (inherited) retroviruses in that its incorporation to the host genome is still active, providing an opportunity to study what drives this fundamental process in vertebrate genome evolution. Animals... Read More about Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution.

Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice (2022)
Journal Article
Appolinário, C. M., Daly, J. M., Emes, R. D., Marchi, F. A., Ribeiro, B. L. D., & Megid, J. (2022). Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice. Viruses, 14(4), Article 692. https://doi.org/10.3390/v14040692

Pathogenicity and pathology of rabies virus (RABV) varies according to the variant, but the mechanisms are not completely known. In this study, gene expression profile in brains of mice experimentally infected with RABV isolated from a human case of... Read More about Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice.

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames (2021)
Journal Article
Blythe, M. J., Kocer, A., Rubio-Roldan, A., Giles, T., Abakir, A., Ialy-Radio, C., …Ruzov, A. (2021). LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames. Communications Biology, 4, Article 691. https://doi.org/10.1038/s42003-021-02217-8

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv... Read More about LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.

Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population (2021)
Journal Article
Tarlinton, R. E., Fabijan, J., Hemmatzadeh, F., Meers, J., Owen, H., Sarker, N., …Emes, R. D. (2021). Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population. Conservation Genetics, https://doi.org/10.1007/s10592-021-01340-7

© 2021, The Author(s). Historical hunting pressures on koalas in the southern part of their range in Australia have led to a marked genetic bottleneck when compared with their northern counterparts. There are a range of suspected genetic disorders su... Read More about Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population.

Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation (2021)
Journal Article
Clare, C. E., Pestinger, V., Kwong, W. Y., Tutt, D. A. R., Xu, J., Byrne, H. M., …Sinclair, K. D. (2021). Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation. International Journal of Molecular Sciences, 22(4), Article 1838. https://doi.org/10.3390/ijms22041838

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation 20 of purines and pyrimidines, biogenic amines, proteins and phospholipids. Our understanding of 21 how 1C pathways operate, however, pertains mostly to the (rat)... Read More about Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation.

A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis (2020)
Journal Article
Archer, N., Egan, S. A., Coffey, T. J., Emes, R. D., Addis, M. F., Ward, P. N., …Leigh, J. A. (2020). A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis. Pathogens, 9(12), 1-23. https://doi.org/10.3390/pathogens9120997

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Streptococcus uberis is a common cause of intramammary infection and mastitis in dairy cattle. Unlike other mammary pathogens, S. uberis evades detection by mammary epithelial cells, and the h... Read More about A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis.

Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication (2020)
Journal Article
Goulding, L. V., Yang, J., Jiang, Z., Zhang, H., Lea, D., Emes, R. D., …Chang, K. C. (2020). Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication. Viruses, 12(10), https://doi.org/10.3390/v12101093

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Influenza A... Read More about Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza a virus replication.

Molecular characterisation of canine osteosarcoma in high risk breeds (2020)
Journal Article
Simpson, S., Dunning, M., de Brot, S., Alibhai, A., Bailey, C., Woodcock, C. L., …Rutland, C. S. (2020). Molecular characterisation of canine osteosarcoma in high risk breeds. Cancers, 12(9), Article 2405. https://doi.org/10.3390/cancers12092405

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dogs develop osteosarcoma (OSA) and the disease process closely resembles that of human OSA. OSA has a poor prognosis in both species and disease-free intervals and cure rates have not improve... Read More about Molecular characterisation of canine osteosarcoma in high risk breeds.

Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., …Singh Kashyap, R. (2020). Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome. Gut Microbes, 12(1), Article 1752605

Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrhoeal diseases, particularly Clostridioides difficile, in rural-agricultural and urban popula... Read More about Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome.

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., …Kashyap, R. S. (2020). Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome. Gut Microbes, 12(1), Article 1752605. https://doi.org/10.1080/19490976.2020.1752605

© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal d... Read More about Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia (2020)
Journal Article
Fabijan, J., Sarker, N., Speight, N., Owen, H., Meers, J., Simmons, G., …Trott, D. J. (2020). Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia. Journal of Comparative Pathology, 176, 50-66. https://doi.org/10.1016/j.jcpa.2020.02.003

© 2020 Elsevier Ltd Koala retrovirus (KoRV) infection shows differences in prevalence and load between northern and southern Australian koala populations; however, the effect of this on diseases such as lymphoma and chlamydial disease is unclear. Thi... Read More about Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia.

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., …Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

© 2020 Elsevier B.V. High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experim... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.

Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells (2020)
Journal Article
Sarker, N., Tarlinton, R., Owen, H., David Emes, R., Seddon, J., Simmons, G., & Meers, J. (2020). Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells. Gene, 733, https://doi.org/10.1016/j.gene.2020.144366

Koala retrovirus is thought to be an underlying cause of high levels of neoplasia and immunosuppression in koalas. While epidemiology studies suggest a strong link between KoRV and disease it has been difficult to prove causality because of the compl... Read More about Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells.