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All Outputs (31)

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article
Ali, W., Elsahn, A., Ting, D. S. J., Dua, H. S., & Mohammed, I. (2022). Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic. Antibiotics, 11(4), Article 475. https://doi.org/10.3390/antibiotics11040475

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies (2021)
Journal Article
Ting, D. S. J., Li, J., Verma, C. S., Goh, E. T., Nubile, M., Mastropasqua, L., …Dua, H. S. (2021). Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies. Frontiers in Pharmacology, 12, Article 731499. https://doi.org/10.3389/fphar.2021.731499

Background/Aim: Host defense peptides (HDPs) have the potential to provide a novel solution to antimicrobial resistance (AMR) in view of their unique and broad-spectrum antimicrobial activities. We had recently developed a novel hybrid HDP based on L... Read More about Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies.

Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis (2021)
Journal Article
Ting, D. S. J., Leng, E. T., Mayandi, V., Busoy, J. M. F., Aung, T. T., Periayah, M. H., …Dua, H. S. (2021). Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. Scientific Reports, 11, Article 18304. https://doi.org/10.1038/s41598-021-97821-3

Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designe... Read More about Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis.

Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells (2021)
Journal Article
Akhtar, R., Tahir, H., Stewart, E., Wei, R., Mohammed, I., & Amoaku, W. M. (2021). Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells. International Journal of Translational Medicine, 1(1), 25-38. https://doi.org/10.3390/ijtm1010003

Retinal diseases are the leading causes of irreversible blindness worldwide. The role of toll-like receptor (TLR) signalling mechanisms (MyD88 and TRIF) in the production of pro-angiogenic growth factors from human microvascular endothelial cells (HM... Read More about Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells.

Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases (2021)
Journal Article
Deshmukh, R., Ting, D. S. J., Elsahn, A., Mohammed, I., Said, D. G., & Dua, H. S. (2022). Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases. British Journal of Ophthalmology, 106(8), 1087-1092. https://doi.org/10.1136/bjophthalmol-2020-317907

Purpose: To report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs). Methods: This was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’... Read More about Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis (2020)
Journal Article
Mohammed, I., Mohanty, D., Said, D. G., Barik, M. R., Reddy, M. M., Alsaadi, A., …Mittal, R. (2021). Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. British Journal of Ophthalmology, 105(8), 1172-1177. https://doi.org/10.1136/bjophthalmol-2020-316329

Background Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infectio... Read More about Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.

Profiling ocular surface responses to preserved and non?preserved topical glaucoma medications: a two?year randomised evaluation study (2020)
Journal Article
Mohammed, I., Kulkarni, B., Faraj, L. A., Abbas, A., Dua, H. S., & King, A. J. (2020). Profiling ocular surface responses to preserved and non?preserved topical glaucoma medications: a two?year randomised evaluation study. Clinical and Experimental Ophthalmology, 48(7), 973-982. https://doi.org/10.1111/ceo.13814

Background Use of topical glaucoma medications has been reported to cause ocular surface (OS) discomfort and inflammation. This study explores the profile of inflammatory cytokines and OS symptoms induced in response to preserved and non‐preserved d... Read More about Profiling ocular surface responses to preserved and non?preserved topical glaucoma medications: a two?year randomised evaluation study.

Strategies in Translating the Therapeutic Potentials of Host Defense Peptides (2020)
Journal Article
Ting, D. S. J., Beuerman, R. W., Dua, H. S., Lakshminarayanan, R., & Mohammed, I. (2020). Strategies in Translating the Therapeutic Potentials of Host Defense Peptides. Frontiers in Immunology, 11, https://doi.org/10.3389/fimmu.2020.00983

The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of... Read More about Strategies in Translating the Therapeutic Potentials of Host Defense Peptides.

Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa (2019)
Journal Article
Mohammed, I., Said, D. G., Nubile, M., Mastropasqua, L., & Dua, H. S. (2019). Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa. Frontiers in Microbiology, 10, Article 2190. https://doi.org/10.3389/fmicb.2019.02190

© Copyright © 2019 Mohammed, Said, Nubile, Mastropasqua and Dua. Pseudomonas aeruginosa (PA) is the leading cause of corneal blindness worldwide. A constant increase in multi-drug resistant PA strains have heightened the challenge of effectively mana... Read More about Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa.

In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles (2019)
Journal Article
Al-Aqaba, M. A., Anis, F. S., Mohammed, I., Yapa, A. D. S., Amoaku, W. M., & Dua, H. S. S. (2019). In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles. British Journal of Ophthalmology, 1-5. https://doi.org/10.1136/bjophthalmol-2018-313199

Aims To describe the in vivo confocal microscopy (IVCM) features of human limbal nerve corpuscles (LNCs) and correlate these with the histological features. Methods We examined 40 eyes of 29 healthy living subjects (17 female, 12 male; mean age=47... Read More about In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles.

Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin) (2019)
Journal Article
Ghoz, N., Britton, J., Ross, A. R., Mohammed, I., Hogan, E., Said, D. G., & Dua, H. S. (2019). Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin). Eye, 33(11), 1776-1783. https://doi.org/10.1038/s41433-019-0493-0

Background To assess the efficacy of combined 5FU and Avastin injections in the treatment of primary pterygium Methods Sixteen eyes with primary pterygium received intralesional 5 fluorouracil and Avastin (2.5–5 mg) injections every 2 weeks... Read More about Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).

Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, 73, Article 100762. https://doi.org/10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More about Corneal nerves in health and disease.

Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice (2019)
Journal Article
Song, D., Ueda, Y., Bhuyan, R., Mohammed, I., Miwa, T., Gullipali, D., …Song, W. (2019). Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. American Journal of Pathology, 189(4), 826-838. https://doi.org/10.1016/j.ajpath.2019.01.009

© 2019 American Society for Investigative Pathology Single-nucleotide polymorphisms and rare mutations in factor H (FH; official name, CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thromb... Read More about Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice.

Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus (2018)
Journal Article
Said, D. G., Ross, A. R., Messina, M., Mohammed, I., & Dua, H. (2018). Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus. Eye, doi:10.1038/s41433-018-0211-3

Corneal collagen cross-linking (CXL) is the only treatment that delays or arrests progression of keratoconus. CXL is a safe procedure with few complications. CXL protocols vary depending on time and energy used but all are safe and effective. Variati... Read More about Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus.

Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling (2018)
Journal Article
Mohammed, I., Ross, A. R., Britton, J. O., Said, D. G., & Dua, H. S. (2018). Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling. American Journal of Ophthalmology, 194, 16-25. https://doi.org/10.1016/j.ajo.2018.07.001

Purpose Descemet membrane endothelial keratoplasty (DMEK) and pre-Descemet endothelial keratoplasty (PDEK) tissues always scroll with the endothelial cells (EC) outside. We designed a study to understand the reason for this behavior. Design... Read More about Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling.

Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease (2018)
Journal Article
Song, D., Mohammed, I., Bhuyan, R., Miwa, T., Williams, A. L., Gullipalli, D., …Song, W. (2018). Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease. Investigative Ophthalmology & Visual Science, 59(8), 3405-3415. https://doi.org/10.1167/iovs.18-24133

Purpose: Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). C... Read More about Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease.

Nerve terminals at the human corneoscleral limbus (2017)
Journal Article
Al -Aqaba, M., Anis, F. S., Mohammed, I., & Dua, H. S. (2017). Nerve terminals at the human corneoscleral limbus. British Journal of Ophthalmology, 102(4), 556-561. doi:10.1136/bjophthalmol-2017-311146

Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus. Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age,... Read More about Nerve terminals at the human corneoscleral limbus.

Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study (2017)
Journal Article
AlTaan, S., Mohammed, I., Said, D., & Dua, H. (2018). Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study. Eye, 32(1), 146-151. https://doi.org/10.1038/eye.2017.121

Purpose: To measure the pressure and volume of air required to create a big bubble (BB) in simulated deep anterior lamellar keratoplasty (DALK) in donor eyes and ascertain the bursting pressure of the BB. Patients and methods: Twenty-two human scler... Read More about Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study.

Human antimicrobial peptides in ocular surface defense (2017)
Journal Article
Mohammed, I., Said, D. G., & Dua, H. S. (2017). Human antimicrobial peptides in ocular surface defense. Progress in Retinal and Eye Research, 61, (1-22). doi:10.1016/j.preteyeres.2017.03.004. ISSN 1350-9462

Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of... Read More about Human antimicrobial peptides in ocular surface defense.

Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation (2017)
Journal Article
Ueda, Y., Mohammed, I., Song, D., Gullipalli, D., Zhou, L., Sato, S., …Song, W. (2017). Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood, 129(9), 1184-1196. https://doi.org/10.1182/blood-2016-07-728253

Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the c... Read More about Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.