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Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains (2020)
Journal Article
Swilaiman, S. S., O’Gorman, C. M., Du, W., Sugui, J. A., Del Buono, J., Brock, M., …Dyer, P. S. (2020). Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains. Journal of Fungi, 6(4), https://doi.org/10.3390/jof6040258

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. A sexual cycle in Aspergillus fumigatus was first described in 2009 with isolates from Dublin, Ireland. However, the extent to which worldwide isolates can undergo sexual reproduction has rema... Read More about Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains.

CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of ?2AR in isogenic hPSC-derived cardiomyocytes (2020)
Journal Article
Kondrashov, A., Mohd Yusof, N. A., Hasan, A., Goulding, J., Kodagoda, T., Hoang, D. M., …Denning, C. (2021). CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. Molecular Therapy - Methods and Clinical Development, 20, 39-53. https://doi.org/10.1016/j.omtm.2020.10.019

© 2020 During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association... Read More about CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of ?2AR in isogenic hPSC-derived cardiomyocytes.

Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies (2020)
Journal Article
Kilpatrick, L. E., & Hill, S. J. (2021). Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies. Current Opinion in Endocrine and Metabolic Research, 16, 102-112. https://doi.org/10.1016/j.coemr.2020.10.003

© 2020 The Authors Alterations in signalling due to bidirectional transactivation of G protein-coupled receptor (GPCRs) and receptor tyrosine kinases (RTKs) are well established. Transactivation significantly diversifies signalling networks within a... Read More about Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies.

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites (2020)
Journal Article
Zeeshan, M., Brady, D., Stanway, R. R., Moores, C., Holder, A. A., & Tewari, R. (2020). Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites. Frontiers in Cellular and Infection Microbiology, 10, Article 583812. https://doi.org/10.3389/fcimb.2020.583812

© Copyright © 2020 Zeeshan, Brady, Stanway, Moores, Holder and Tewari. Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for prope... Read More about Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites.

The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review (2020)
Journal Article
Williams, M., Todd, I., & Fairclough, L. C. (2020). The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review. Inflammation Research, https://doi.org/10.1007/s00011-020-01408-z

© 2020, The Author(s). Objective and design: This systematic review aims to establish the role of CD8 + T lymphocytes in COPD. Methods: Forty-eight papers published in the last 15years were identified for inclusion. Results: CD8 + T-cells are increas... Read More about The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.

Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments. Computational and Structural Biotechnology Journal, 18, 2860-2866. https://doi.org/10.1016/j.csbj.2020.09.030

© 2020 The Author(s) Spatial structure over scales ranging from nanometres to centimetres (and beyond) varies markedly in diverse habitats and the industry-relevant settings that support microbial activity. Developing an understanding of the interpla... Read More about Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments.

Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression (2020)
Journal Article
Villota, S. D., Toledo-Rodriguez, M., & Leach, L. (2021). Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression. Diabetologia, 64, 195-210. https://doi.org/10.1007/s00125-020-05290-6

© 2020, The Author(s). Aims/hypothesis: Reduced occupancy of junctional occludin is a feature of human placental vessels in the diabetic milieu. However, the functional consequence of this and whether this loss is due to differential expression of oc... Read More about Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism (2020)
Journal Article
Kim, K., Kwon, T., Dessie, T., Yoo, D. A., Mwai, O. A., Jang, J., …Kim, H. (2020). The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism. Nature Genetics, 52(10), 1099-1110. https://doi.org/10.1038/s41588-020-0694-2

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence an... Read More about The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism.

Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action (2020)
Journal Article
Wohlgemuth, F., Gomes, R. L., Singleton, I., Rawson, F. J., & Avery, S. V. (2020). Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action. Frontiers in Microbiology, 11, Article 575157. https://doi.org/10.3389/fmicb.2020.575157

© Copyright © 2020 Wohlgemuth, Gomes, Singleton, Rawson and Avery. We developed a top-down strategy to characterize an antimicrobial, oxidizing sanitizer, which has diverse proposed applications including surface-sanitization of fresh foods, and with... Read More about Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action.

A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice (2020)
Journal Article
Mosa, A. I., Urbanowicz, R. A., AbouHaidar, M. G., Tavis, J. E., Ball, J. K., & Feld, J. J. (2020). A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice. Vaccine, 38(44), 6864-6867. https://doi.org/10.1016/j.vaccine.2020.08.066

© 2020 Elsevier Ltd Vaccine development for antigenically variable pathogens has faltered because extreme genetic diversity precludes induction of broadly neutralizing antibodies (nAB) with classical vaccines. Here, using the most variable epitope of... Read More about A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice.

Fasting and surgery timing (FaST) audit (2020)
Journal Article
El-Sharkawy, A. M., Daliya, P., Lewis-Lloyd, C., Adiamah, A., Malcolm, F. L., Boyd-Carson, H., …Wolff, J. (2021). Fasting and surgery timing (FaST) audit. Clinical Nutrition, 40(3), 1405-1412. https://doi.org/10.1016/j.clnu.2020.08.033

Background & aims International guidance advocates the avoidance of prolonged preoperative fasting due to its negative impact on perioperative hydration. This study aimed to assess the adherence to these guidelines for fasting in patients undergoi... Read More about Fasting and surgery timing (FaST) audit.

The glucosyltransferase activity of C. difficile toxin b is required for disease pathogenesis (2020)
Journal Article
Bilverstone, T. W., Garland, M., Cave, R. J., Kelly, M. L., Tholen, M., Bouley, D. M., …Melnyk, R. A. (2020). The glucosyltransferase activity of C. difficile toxin b is required for disease pathogenesis. PLoS Pathogens, 16(9), Article e1008852. https://doi.org/10.1371/journal.ppat.1008852

© 2020 Bilverstone et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar... Read More about The glucosyltransferase activity of C. difficile toxin b is required for disease pathogenesis.

Discovery of hemocompatible bacterial biofilm-resistant copolymers (2020)
Journal Article
Singh, T., Hook, A. L., Luckett, J., Maitz, M. F., Sperling, C., Werner, C., …Alexander, M. R. (2020). Discovery of hemocompatible bacterial biofilm-resistant copolymers. Biomaterials, 260, Article 120312. https://doi.org/10.1016/j.biomaterials.2020.120312

© 2020 The Authors Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with t... Read More about Discovery of hemocompatible bacterial biofilm-resistant copolymers.

The Ancient Tree Inventory: a summary of the results of a 15 year citizen science project recording ancient, veteran and notable trees across the UK (2020)
Journal Article
Nolan, V., Reader, T., Gilbert, F., & Atkinson, N. (2020). The Ancient Tree Inventory: a summary of the results of a 15 year citizen science project recording ancient, veteran and notable trees across the UK. Biodiversity and Conservation, https://doi.org/10.1007/s10531-020-02033-2

© 2020, The Author(s). Ancient, veteran and notable trees are ecologically important keystone organisms and have tangible connections to folklore, history and sociocultural practices. Although found worldwide, few countries have such a rich history o... Read More about The Ancient Tree Inventory: a summary of the results of a 15 year citizen science project recording ancient, veteran and notable trees across the UK.

Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men (2020)
Journal Article
Jones, R., Pabla, P., Mallinson, J., Nixon, A., Taylor, T., Bennett, A., & Tsintzas, K. (2020). Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men. American Journal of Clinical Nutrition, 112(4), 1015-1028. https://doi.org/10.1093/ajcn/nqaa192

Copyright © The Author(s) on behalf of the American Society for Nutrition 2020. BACKGROUND: Altering the temporal distribution of energy intake (EI) and introducing periods of intermittent fasting (IF) exert important metabolic effects. Restricting E... Read More about Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.

Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical ?-Blockers (2020)
Journal Article
Baker, J. G., Fromont, C., Bruder, M., Thompson, K. S., Kellam, B., Hill, S. J., …Fischer, P. M. (2020). Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers. ACS Pharmacology & Translational Science, 3(4), 737-748. https://doi.org/10.1021/acsptsci.0c00051

© 2020 American Chemical Society. For disorders of the skin, eyes, ears, and respiratory tract, topical drugs, delivered directly to the target organ, are a therapeutic option. Compared with systemic oral therapy, the benefits of topical treatments i... Read More about Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical ?-Blockers.