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Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal (2018)
Journal Article
Sarkar, B., Sarkar, S., Das, M., Bhowmick, T., Koley, H., Atterbury, R., & Chakrabarti, A. (2018). Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal. Journal of Global Infectious Diseases, 10(2), https://doi.org/10.4103/jgid.jgid_37_17

Objectives: We have isolated a total of five newer cholera phages which are novel broad host range to incorporate with the existing phage typing schemes for an extended typing scheme. Materials and Methods: These newly isolated phages were well chara... Read More about Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal.

Gainfully employing descending controls in acute and chronic pain management (2018)
Journal Article
White, K., Targett, M., & Harris, J. (2018). Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237, https://doi.org/10.1016/j.tvjl.2018.05.005

Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive... Read More about Gainfully employing descending controls in acute and chronic pain management.

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma (2018)
Journal Article
De Santo, C., Cheng, P., Beggs, A., Egan, S., Bessudo, A., & Mussai, F. (2018). Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. Journal of Hematology and Oncology, 11, Article 68. https://doi.org/10.1186/s13045-018-0612-6

Background Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 ant... Read More about Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.

Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life (2018)
Journal Article
Fragkoudis, R., Dixon-Ballany, C., Zagrajek, A., Kedzierski, L., & Fazakerley, J. (2018). Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life. Viruses, 10(5), Article 273. https://doi.org/10.3390/v10050273

Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthralgia, myalgia and more severely, encephalitis. In the mouse, peripheral infection with Semliki Forest virus (SFV) result... Read More about Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life.

Student perceptions of veterinary anatomy practical classes: a longitudinal study (2018)
Journal Article
Gummery, E., Cobb, K. A., Mossop, L. H., & Cobb, M. A. (2018). Student perceptions of veterinary anatomy practical classes: a longitudinal study. Journal of Veterinary Medical Education, 45(2), https://doi.org/10.3138/jvme.0816-132r1

Using cadaveric material to teach veterinary students poses many challenges. However, little research exists on the contribution of this traditional approach to student learning. This longitudinal study aimed to investigate student perceptions of cad... Read More about Student perceptions of veterinary anatomy practical classes: a longitudinal study.

Quality of life assessment in companion animals: what, why, who, when and how (2018)
Journal Article
Belshaw, Z. (in press). Quality of life assessment in companion animals: what, why, who, when and how. Companion Animal, 23(5), https://doi.org/10.12968/coan.2018.23.5.264

Quality of life is a commonly used phrase in veterinary medicine. It describes a complex evaluation that may be difficult for animals to perform, and the phrase “happiness” may be a more crude but useful approximation. Quality of life assessments sho... Read More about Quality of life assessment in companion animals: what, why, who, when and how.

Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle (2018)
Journal Article
Barker, Z., Vázquez Diosdado, J. A., Codling, E., Bell, N., Hodges, H., Croft, D., & Amory, J. (2018). Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle. Journal of Dairy Science, 101(7), https://doi.org/10.3168/jds.2016-12172

Time constraints for dairy farmers are an important factor contributing to the under-detection of lameness, resulting in delayed or missed treatment of lame cows within many commercial dairy herds. Hence, a need exists for flexible and affordable cow... Read More about Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle.

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article
Anand-Ivell, R., Cohen, A., Norgaard-Pedersen, B., Joenssen, B., Bonde, J., Hougaard, D. M., …Ivell, R. (2018). Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study. Frontiers in Physiology, 9, Article 408. https://doi.org/10.3389/fphys.2018.00406

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More about Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study.

Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours (2018)
Journal Article
Richens, I., Houdmont, J., Wapenaar, W., Shortall, O., Kaler, J., O’Connor, H., & Brennan, M. L. (2018). Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours. Preventive Veterinary Medicine, 155, https://doi.org/10.1016/j.prevetmed.2018.04.010

It has been recognised that few cattle farmers undertake biosecurity practices on their farms. Approaches that take into consideration individuals’ preparedness for change, alongside beliefs thought to motivate the enactment of certain behaviours, ma... Read More about Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours.

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host (2018)
Journal Article
Calvo-Pinilla, E., Gubbins, S., Mertens, P. P., Ortego, J., & Castillo-Olivares, J. (2018). The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host. Antiviral Research, 154, https://doi.org/10.1016/j.antiviral.2018.04.015

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside... Read More about The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis (2018)
Journal Article
Wang, J., Li, T., Elsheikha, H. M., Chen, K., Cong, W., Yang, W., …Zhu, X. (2018). Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis. Journal of Infectious Diseases, 218(5), 768–777. https://doi.org/10.1093/infdis/jiy211

Background: The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by live-attenuated strain of T.... Read More about Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis.

Associations between dairy cow inter-service interval and probability of conception (2018)
Journal Article
Remnant, J., Green, M., Huxley, J., & Hudson, C. (2018). Associations between dairy cow inter-service interval and probability of conception. Theriogenology, 114, 324-329. https://doi.org/10.1016/j.theriogenology.2018.03.029

Recent research has indicated that the interval between inseminations in modern dairy cattle is often longer than the commonly accepted cycle length of 18–24 days. This study analysed 257,396 inseminations in 75,745 cows from 312 herds in England and... Read More about Associations between dairy cow inter-service interval and probability of conception.

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses (2018)
Journal Article
Slater, T., Eckerle, I., & Chang, K. (2018). Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses. Virology Journal, 15, Article 68. https://doi.org/10.1186/s12985-018-0979-6

Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible... Read More about Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.

Holographic optical trapping Raman micro-spectroscopy for interacting live cells (2018)
Working Paper
Sinjab, F., Elsheikha, H. M., Awuah, D., Gibson, G., Padgett, M., Ghaemmaghami, A. M., & Notingher, I. Holographic optical trapping Raman micro-spectroscopy for interacting live cells

We present a combined holographic optical tweezers and confocal Raman spectroscopy instrument which allows fast, flexible, and interactive manipulation with molecular measurement of interacting live cell systems. Multiple laser foci created using a s... Read More about Holographic optical trapping Raman micro-spectroscopy for interacting live cells.

Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines (2018)
Journal Article
Belshaw, Z., Robinson, N. J., Dean, R. S., & Brennan, M. L. (2018). Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines. Preventive Veterinary Medicine, 154, https://doi.org/10.1016/j.prevetmed.2018.03.020

Routine use of preventative medicines is advocated as part of responsible dog and cat ownership. However, it has been suggested that the number of owners in the United Kingdom (UK) using preventative medicines to protect their pets is in decline. The... Read More about Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines.

The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus (2018)
Journal Article
Blanchard, A. M., Jolley, K. A., Maiden, M. C., Coffey, T. J., Maboni, G., Staley, C. E., …Tötemeyer, S. (in press). The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus. Frontiers in Microbiology, 9, Article 551. https://doi.org/10.3389/fmicb.2018.00551

Dichelobacter nodosus (D. nodosus) is the causative pathogen of ovine footrot, a disease that has a significant welfare and financial impact on the global sheep industry. Previous studies into the phylogenetics of D. nodosus have focused on Australia... Read More about The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus.

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), 16008-16027. https://doi.org/10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More about Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy.

Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., Tazetdinoval, L. G., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment. Frontiers in Pharmacology, 9, Article 259. https://doi.org/10.3389/fphar.2018.00259

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circu... Read More about Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment.

A step in the right direction: an open-design pedometer algorithm for dogs (2018)
Journal Article
Ladha, C., Belshaw, Z., O’Sullivan, J., & Asher, L. (2018). A step in the right direction: an open-design pedometer algorithm for dogs. BMC Veterinary Research, 14, Article 107. https://doi.org/10.1186/s12917-018-1422-3

Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this paper was... Read More about A step in the right direction: an open-design pedometer algorithm for dogs.