All Outputs (1370)

Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level (2023)
Journal Article
Atallah, N. M., Alsaleem, M., Toss, M. S., Mongan, N. P., & Rakha, E. (2023). Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level. British Journal of Cancer, https://doi.org/10.1038/s41416-023-02426-4

Background: Increasing data indicate that HER2-positive (HER2 +) breast cancer (BC) subtypes exhibit differential responses to targeted anti-HER2 therapy. This study aims to investigate these differences and the potential underlying molecular mechani... Read More about Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level.

Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses (2023)
Journal Article
Mohd Jaafar, F., Belhouchet, M., Monsion, B., Bell-Sakyi, L., Mertens, P. P. C., & Attoui, H. (2023). Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses. Viruses, 15(9), Article 1908. https://doi.org/10.3390/v15091908

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the inter... Read More about Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.

Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study (2023)
Journal Article
Nunney, E., Crotta, M., van Winden, S., Bond, K., Green, M., & Guitian, J. (2023). Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study. Preventive Veterinary Medicine, 219, Article 106022. https://doi.org/10.1016/j.prevetmed.2023.106022

Johne's disease (JD) is a chronic disease of ruminants endemic in the UK and other countries and responsible for large economic losses for the dairy sector. JD is caused by Mycobacterium avium subspecies paratuberculosis (MAP), which typically infect... Read More about Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study.

Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display (2023)
Book Chapter
Tsoumpeli, M. T., Varghese, A., Owen, J. P., Maddison, B. C., Daly, J. M., & Gough, K. C. (2023). Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display. In M. Hust, & T. S. Lim (Eds.), Phage Display (467-487). Springer US. https://doi.org/10.1007/978-1-0716-3381-6_25

Peptide phage display has historically been used to epitope map monoclonal antibodies. More recently, by coupling this method with next-generation sequencing (so-called next-generation phage display, NGPD) to mass screen peptide binding events, the m... Read More about Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display.

Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets (2023)
Journal Article
Sun, H., Li, H., Tong, Q., Han, Q., Liu, J., Yu, H., …Liu, J. (2023). Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. Cell, 186(19), 4074-4084.e11. https://doi.org/10.1016/j.cell.2023.08.011

H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses are widespread in chicken flocks; however, the zoonotic features of H3N8 viruses are poorly understood... Read More about Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets.

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep (2023)
Journal Article
Evans, N. P., Bellingham, M., Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D., & Padmanabhan, V. (2023). Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology, 102, Article 104257. https://doi.org/10.1016/j.etap.2023.104257

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed t... Read More about Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.

Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer (2023)
Journal Article
Wong, K., Abascal, F., Ludwig, L., Aupperle-Lellbach, H., Grassinger, J., Wright, C. W., …van der Weyden, L. (2023). Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer. Genome Biology, 24(1), Article 191. https://doi.org/10.1186/s13059-023-03026-4

Background: In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver events are necessary. Dogs and cat... Read More about Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer.

Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers (2023)
Journal Article
Doidge, C., Frössling, J., C. Dórea, F., Ordell, A., Vidal, G., & Kaler, J. (2023). Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers. Frontiers in Veterinary Science, 10, Article 1171107. https://doi.org/10.3389/fvets.2023.1171107

Introduction: Livestock farmers are being increasingly encouraged to adopt digital health technologies on their farms. Digital innovations may have unintended consequences, but there tends to be a pro-innovation bias in previous literature. This... Read More about Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers.

Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK (2023)
Journal Article
Smits, F., Houdmont, J., Hill, B., & Pickles, K. (2023). Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK. Veterinary Record, 193(8), Article e3311. https://doi.org/10.1002/vetr.3311

Background: Certain autistic characteristics (such as hyper-focus and attention to detail) are valued by veterinary surgeons and autistic adults may disproportionately self-select into the profession. Links between mental wellbeing and retention in t... Read More about Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK.

Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry (2023)
Journal Article
Alsafy, M. A., El-Gendy, S. A., Kamal, B. M., Rutland, C. S., Abd-Elhafeez, H. H., Soliman, S., …Nomir, A. G. (2023). Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry. BMC Zoology, 8, Article 12. https://doi.org/10.1186/s40850-023-00173-w

Dromedary camel heart morphology is a crucial research topic with clinical applications. The study aims to understand the dromedary camel anatomy, morphology, and architecture of the ventricular mass. Results: Sagittal and transverse gross sections w... Read More about Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry.

A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment (2023)
Journal Article
Todman, H., Arya, S., Baker, M., & Stekel, D. J. (2023). A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment. PLoS ONE, 18(8), Article e0289941. https://doi.org/10.1371/journal.pone.0289941

Antimicrobial resistant bacterial infections represent one of the most serious contemporary global healthcare crises. Acquisition and spread of resistant infections can occur through community, hospitals, food, water or endogenous bacteria. Global ef... Read More about A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment.

Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging (2023)
Journal Article
Jewitt, S., Smallman-Raynor, M., McClaughlin, E., Clark, M., Dunham, S., Elliott, S., …Tarlinton, R. (2023). Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging. Heliyon, 9(9), Article E19211. https://doi.org/10.1016/j.heliyon.2023.e19211

Understanding how smallscale (‘backyard’) poultry keepers interpret and respond to governmental directives designed to reduce the transmission of highly pathogenic avian influenza (HPAI) is of paramount importance in preparing for future HPAI outbrea... Read More about Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging.

Comparison of multiple international metrics for benchmarking antibiotic usage (ABU) using UK beef and sheep data. (2023)
Journal Article
Davies, P., Hyde, R., & Corbishley, A. (2023). Comparison of multiple international metrics for benchmarking antibiotic usage (ABU) using UK beef and sheep data. Journal of Antimicrobial Chemotherapy, 78(10), 2496–2504. https://doi.org/10.1093/jac/dkad259

Accurate surveillance of livestock antibiotic usage (ABU) at the farm level is an increasingly important part of national antibiotic stewardship initiatives. Numerous ABU indicators or metrics have been developed in Europe and North America but the c... Read More about Comparison of multiple international metrics for benchmarking antibiotic usage (ABU) using UK beef and sheep data..

Immune responses to Tilapia lake virus infection: what we know and what we don't know (2023)
Journal Article
Kembou-Ringert, J. E., Steinhagen, D., Thompson, K. D., Daly, J. M., & Adamek, M. (2023). Immune responses to Tilapia lake virus infection: what we know and what we don't know. Frontiers in Immunology, 14, Article 1240094. https://doi.org/10.3389/fimmu.2023.1240094

Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent... Read More about Immune responses to Tilapia lake virus infection: what we know and what we don't know.

Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance (2023)
Journal Article
Panner Selvam, M. K., Kanagaraj, V., Kathaperumal, K., Nissly, R. H., Daly, J. M., & Kuchipudi, S. V. (2023). Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance. VirusDisease, 34, 402–409. https://doi.org/10.1007/s13337-023-00833-y

Newcastle disease (ND) affects a few hundred avian species including chicken and several species of domestic and wild birds. The clinical outcome of Newcastle disease virus (NDV) infection ranges from mild to severe fatal disease depending on the NDV... Read More about Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance.

Predicting lameness in dairy cattle using untargeted liquid chromatography–mass spectrometry-based metabolomics and machine learning (2023)
Journal Article
Randall, L. V., Kim, D., Abdelrazig, S. M., Bollard, N. J., Hemingway-Arnold, H., Hyde, R. M., …Green, M. J. (2023). Predicting lameness in dairy cattle using untargeted liquid chromatography–mass spectrometry-based metabolomics and machine learning. Journal of Dairy Science, 106(10), 7033-7042. https://doi.org/10.3168/jds.2022-23118

Lameness in dairy cattle is a highly prevalent condition that impacts on the health and welfare of dairy cows. Prompt detection and implementation of effective treatment is important for managing lameness. However, major limitations are associated wi... Read More about Predicting lameness in dairy cattle using untargeted liquid chromatography–mass spectrometry-based metabolomics and machine learning.

A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer (2023)
Journal Article
Ebanks, B., Kwiecinska, P., Moisoi, N., & Chakrabarti, L. (2023). A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer. PLoS ONE, 18(7), Article e0276147. https://doi.org/10.1371/journal.pone.0276147

High-resolution respirometry methods allow for the assessment of oxygen consumption by the electron transfer systems within cells, tissue samples, and isolated mitochondrial preparations. As mitochondrial integrity is compromised by the process of cr... Read More about A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer.

Luteal phase decrease in packed cell volume in healthy non‐pregnant and pregnant bitches (2023)
Journal Article
Moxon, R., Dutton Worsfold, R., Davis, J., Adams, W., & England, G. C. W. (2023). Luteal phase decrease in packed cell volume in healthy non‐pregnant and pregnant bitches. Veterinary Medicine and Science, https://doi.org/10.1002/vms3.1195

Objectives: To establish packed cell volume (PCV) ranges for non‐pregnant, pregnant and post‐partum bitches from day 10 of proestrus, investigating any relationship with parity and litter size. Methods: This prospective cohort study used 37 healthy b... Read More about Luteal phase decrease in packed cell volume in healthy non‐pregnant and pregnant bitches.

The clinical and biological significance of estrogen receptor-low positive breast cancer (2023)
Journal Article
Makhlouf, S., Althobi, M., Toss, M., Muftah, A. A., Mongan, N. P., Lee, A. H. S., …Rakha, E. A. (2023). The clinical and biological significance of estrogen receptor-low positive breast cancer. Modern Pathology, 36(10), Article 100284. https://doi.org/10.1016/j.modpat.2023.100284

Estrogen Receptor (ER) status in breast cancer (BC) is determined using immunohistochemistry (IHC) with nuclear expression in ≥1% of cells defined as ER-positive. BC with 1-9% expression (ER-low positive), is a clinically and biologically unique subg... Read More about The clinical and biological significance of estrogen receptor-low positive breast cancer.