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Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro (2017)
Journal Article
Maddison, B. C., Workman, R. G., & Gough, K. C. (in press). Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro. Prion, 11(4), https://doi.org/10.1080/19336896.2017.1342919

Prion diseases are fatal and incurable neurodegenerative diseases of humans and animals. Despite years of research, no therapeutic agents have been developed that can effectively manage or reverse disease progression. Recently it has been identified... Read More about Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro.

Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers (2017)
Journal Article
Lee, S. A., Wiseman, J., Masey O’Neill, H. V., Scholey, D. V., Burton, E. J., & Hill, S. E. (2017). Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers. Journal of World's Poultry Research, The, 7(2),

The objective of the current study was to investigate the mechanisms of xylanase action in a maize-soya diet and its effect on starch digestion. A total of 60 broilers were divided into 6 treatment groups; a control group without xylanase, and five o... Read More about Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers.

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus (2017)
Journal Article
Glynn, D. J., Heng, K., Russell, D. L., Sharkey, D. J., Robertson, S. A., Anand-Ivell, R., & Ivell, R. (2017). Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus. Frontiers in Physiology, 8, Article 422. https://doi.org/10.3389/fphys.2017.00422

The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract. We hypothesized that relaxin might be one comp... Read More about Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine (2017)
Journal Article
Dai, Y., Ivell, R., Liu, X., Janowski, D., & Anand-Ivell, R. (2017). Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine. Frontiers in Physiology, 8, Article 359. https://doi.org/10.3389/fphys.2017.00359

In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep. While, these ruminants appear to... Read More about Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine.

The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep (2017)
Journal Article
Williams, J. R., Williams, N. E., & Kendall, N. R. (in press). The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep. Livestock Science, 200, https://doi.org/10.1016/j.livsci.2017.04.010

Cobalt and selenium are essential trace elements required for ruminants. There are many different methods of supplementation available to sheep including boluses, in feed, free access minerals, pasture dressing and oral drenches. Recent changes in Eu... Read More about The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep.

Mouse mitochondrial lipid composition is defined by age in brain and muscle (2017)
Journal Article
Pollard, A. K., Ortori, C. A., Stöger, R., Barrett, D. A., & Chakrabarti, L. (in press). Mouse mitochondrial lipid composition is defined by age in brain and muscle. Aging, 9(3), https://doi.org/10.18632/aging.101204

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-hi... Read More about Mouse mitochondrial lipid composition is defined by age in brain and muscle.

Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection (2017)
Journal Article
Cong, W., Zhang, X., He, J., Li, F., Elsheikha, H. M., & Zhu, X. (2017). Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection. Oncotarget, 8(15), https://doi.org/10.18632/oncotarget.16108

Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expres... Read More about Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders (2017)
Journal Article
Lee, J. L., Bertoglio, L. J., Guimaraes, F. S., & Stevenson, C. W. (in press). Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. British Journal of Pharmacology, https://doi.org/10.1111/bph.13724

Learning to associate cues or contexts with potential threats or rewards is adaptive and enhances survival. Both aversive and appetitive memories are therefore powerful drivers of behaviour, but the inappropriate expression of conditioned responding... Read More about Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders.

Relaxin-like peptides in male reproduction: a human perspective (2017)
Journal Article
Ivell, R., Agoulnik, A. I., & Anand-Ivell, R. (2017). Relaxin-like peptides in male reproduction: a human perspective. British Journal of Pharmacology, 174(10), 990-1001. https://doi.org/10.1111/bph.13689

The relaxin family of peptide hormones and their cognate GPCRs are becoming physiologically well-characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of... Read More about Relaxin-like peptides in male reproduction: a human perspective.

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), https://doi.org/10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More about HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.

Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica (2017)
Journal Article
Zhang, F., Zhang, X., Elsheikha, H. M., He, J., Sheng, Z., Zheng, W., …Zhu, X. (2017). Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica. Parasites and Vectors, 10(1), Article 56. https://doi.org/10.1186/s13071-017-1990-2

Background Fasciola gigantica, the tropical liver fluke, infects buffaloes in Asian and African countries and causes significant economic losses and poses public health threat in these countries. However, little is known of the transcriptional respo... Read More about Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.

Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain (2017)
Journal Article
Wang, J., Li, T., Elsheikha, H. M., Chen, K., Zhu, W., Yue, D., …Huang, S. (in press). Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain. Frontiers in Microbiology, 8, Article 84. https://doi.org/10.3389/fmicb.2017.00084

Toxoplasma gondii is an obligatory intracellular apicomplexan protozoan which can infect any warm-blooded animal and causes severe diseases in immunocompromised individuals or infants infected in utero. The survival and success of this parasite requi... Read More about Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain.

Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system (2017)
Journal Article
Liu, Q., Li, F., Elsheikha, H. M., Sun, M., & Zhu, X. (2017). Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system. Parasites and Vectors, 10(1), https://doi.org/10.1186/s13071-016-1943-1

Background Toxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order to maintain its intracellular survival. This parasite can modulate signaling pathways of its host t... Read More about Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system.

Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring (2016)
Journal Article
Speight, A., Davey, W., McKenna, E., & Voigt, J. (2017). Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring. International Journal of Developmental Neuroscience, 57, https://doi.org/10.1016/j.ijdevneu.2016.12.005

The early postnatal period is a sensitive period in rodents as behavioural systems are developing and maturing during this time. However, little is currently known about the behavioural effects of feeding a hyper-energetic cafeteria diet (CD) during... Read More about Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring.

Bidirectional effects of cannabidiol on contextual fear memory extinction (2016)
Journal Article
Song, C., Stevenson, C. W., Guimaraes, F. S., & Lee, J. L. (2016). Bidirectional effects of cannabidiol on contextual fear memory extinction. Frontiers in Pharmacology, 7(493), https://doi.org/10.3389/fphar.2016.00493

Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation. Here, we... Read More about Bidirectional effects of cannabidiol on contextual fear memory extinction.

Proteomic profiling of mitochondria: what does it tell us about the ageing brain? (2016)
Journal Article
Ingram, T., & Chakrabarti, L. (2016). Proteomic profiling of mitochondria: what does it tell us about the ageing brain?. Aging, 8(12), https://doi.org/10.18632/aging.101131

Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have m... Read More about Proteomic profiling of mitochondria: what does it tell us about the ageing brain?.

Characterisation of monoclonal antibodies specific for hamster leukocyte differentiation molecules (2016)
Journal Article
Rees, J., Haig, D., Mack, V., & Davis, W. C. (in press). Characterisation of monoclonal antibodies specific for hamster leukocyte differentiation molecules. Veterinary Immunology and Immunopathology, 183, https://doi.org/10.1016/j.vetimm.2016.12.003

Flow cytometry was used to identify mAbs that recognize conserved epitopes on hamster leukocyte differentiation molecules (hLDM) and also to characterize mAbs developed against hLDM. Initial screening of mAbs developed against LDMs in other species y... Read More about Characterisation of monoclonal antibodies specific for hamster leukocyte differentiation molecules.

Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders (2016)
Journal Article
Jurkus, R., Day, H. L., Guimaraes, F. S., Lee, J. L., Bertoglio, L. J., & Stevenson, C. W. (2016). Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders. Frontiers in Pharmacology, 7(454), https://doi.org/10.3389/fphar.2016.00454

Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effe... Read More about Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders.