All Outputs (1449)

Stabilization of Polyoxometalate Charge Carriers via Redox‐Driven Nanoconfinement in Single‐Walled Carbon Nanotubes (2022)
Journal Article
Jordan, J. W., Cameron, J. M., Lowe, G. A., Rance, G. A., Fung, K. L. Y., Johnson, L. R., …Newton, G. N. (2022). Stabilization of Polyoxometalate Charge Carriers via Redox‐Driven Nanoconfinement in Single‐Walled Carbon Nanotubes. Angewandte Chemie, 134(8), Article e202115619. https://doi.org/10.1002/ange.202115619

We describe the preparation of hybrid redox materials based on polyoxomolybdates encapsulated within single-walled carbon nanotubes (SWNTs). Polyoxomolybdates readily oxidize SWNTs under ambient conditions in solution, and here we study their charge-... Read More about Stabilization of Polyoxometalate Charge Carriers via Redox‐Driven Nanoconfinement in Single‐Walled Carbon Nanotubes.

Magnetic nanoribbons with embedded cobalt grown inside single-walled carbon nanotubes (2021)
Journal Article
Krichevsky, D. M., Shi, L., Baturin, V. S., Rybkovsky, D. V., Wu, Y., Fedotov, P. V., …Chernov, A. I. (2022). Magnetic nanoribbons with embedded cobalt grown inside single-walled carbon nanotubes. Nanoscale, 14(5), 1978-1989. https://doi.org/10.1039/d1nr06179h

Molecular magnetism and specifically magnetic molecules have recently gained plenty of attention as key elements for quantum technologies, information processing, and spintronics. Transition to the nanoscale and implementation of ordered structures w... Read More about Magnetic nanoribbons with embedded cobalt grown inside single-walled carbon nanotubes.

Auger electron angular distributions following excitation or ionization from the Xe 3d and F 1s levels in xenon difluoride (2021)
Journal Article
Forbes, R., Hockett, P., Powis, I., Bozek, J. D., Pratt, S. T., & Holland, D. M. P. (2022). Auger electron angular distributions following excitation or ionization from the Xe 3d and F 1s levels in xenon difluoride. Physical Chemistry Chemical Physics, 24(3), 1367-1379. https://doi.org/10.1039/d1cp04797c

Linearly polarized synchrotron radiation has been used to record polarization dependent, non-resonant Auger electron spectra of XeF2, encompassing the bands due to the xenon M45N1N45, M45N23N45, M45N45N45 and M45N45V and fluorine KVV transitions. Res... Read More about Auger electron angular distributions following excitation or ionization from the Xe 3d and F 1s levels in xenon difluoride.

Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides (2021)
Journal Article
Sun, W., Kayal, S., Raimbach, W. A. T., Sun, X. Z., Light, M. E., Hanson-Heine, M. W. D., …Harrowven, D. C. (2022). Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides. Chemical Communications, 58(10), 1546-1549. https://doi.org/10.1039/d1cc06800h

Ninhydrin bis-acetals give access to 8-ring lactones, benzocyclo-butenes and spirocyclic orthoanhydrides through photoextrusion and tandem photoextrusion reactions. Syntheses of fimbricalyxlactone B, isoshihunine and numerous biologically-relevant he... Read More about Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (2022). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), Article 126. https://doi.org/10.3390/ijms23010126

Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs in an an... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing (2021)
Journal Article
Hu, Q., Rance, G. A., Trindade, G. F., Pervan, D., Jiang, L., Foerster, A., …Wildman, R. D. (2022). The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing. Additive Manufacturing, 51, Article 102575. https://doi.org/10.1016/j.addma.2021.102575

Two-photon polymerisation (2PP) based additive manufacturing has emerged as a powerful technology to fabricate complex three-dimensional micro- and nanoscale architectures. However, a comprehensive understanding of the effect of printing parameters o... Read More about The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing.

Activity and substrate specificity of lytic polysaccharide monooxygenases: An ATR FTIR-based sensitive assay tested on a novel species from Pseudomonas putida (2021)
Journal Article
Serra, I., Piccinini, D., Paradisi, A., Ciano, L., Bellei, M., Bortolotti, C. A., …Di Rocco, G. (2022). Activity and substrate specificity of lytic polysaccharide monooxygenases: An ATR FTIR-based sensitive assay tested on a novel species from Pseudomonas putida. Protein Science, 31(3), 591-601. https://doi.org/10.1002/pro.4255

Pseudomonas putida W619 is a soil Gram-negative bacterium commonly used in environmental studies thanks to its ability in degrading many aromatic compounds. Its genome contains several putative carbohydrate-active enzymes such as glycoside hydrolases... Read More about Activity and substrate specificity of lytic polysaccharide monooxygenases: An ATR FTIR-based sensitive assay tested on a novel species from Pseudomonas putida.

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins (2021)
Journal Article
Brennan, A., Layfield, R., Long, J., Williams, H. E., Oldham, N. J., Scott, D., & Searle, M. S. (2022). An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins. Journal of Biological Chemistry, 298(2), Article 101514. https://doi.org/10.1016/j.jbc.2021.101514

Recognition of human autophagy-related 8 (hATG8) proteins by autophagy receptors represents a critical step within this cellular quality control system. Autophagy impairment is known to be a pathogenic mechanism in the motor neuron disorder amyotroph... Read More about An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.

Self-Optimization of Continuous Flow Electrochemical Synthesis Using Fourier Transform Infrared Spectroscopy and Gas Chromatography (2021)
Journal Article
Ke, J., Gao, C., Folgueiras-Amador, A. A., Jolley, K. E., de Frutos, O., Mateos, C., …George, M. W. (2022). Self-Optimization of Continuous Flow Electrochemical Synthesis Using Fourier Transform Infrared Spectroscopy and Gas Chromatography. Applied Spectroscopy, 76(1), 38-50. https://doi.org/10.1177/00037028211059848

A continuous-flow electrochemical synthesis platform has been developed to enable self-optimization of reaction conditions of organic electrochemical reactions using attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) and... Read More about Self-Optimization of Continuous Flow Electrochemical Synthesis Using Fourier Transform Infrared Spectroscopy and Gas Chromatography.

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin (2021)
Journal Article
Al-Beltagi, S., Goulding, L. V., Chang, D. K., Mellits, K. H., Hayes, C. J., Gershkovich, P., …Chang, K. (2021). Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin. Virulence, 12(1), 2946-2956. https://doi.org/10.1080/21505594.2021.2006960

The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for thei... Read More about Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.

Supramolecular assemblies of organo-functionalised hybrid polyoxometalates: From functional building blocks to hierarchical nanomaterials (2021)
Journal Article
Cameron, J. M., Guillemot, G., Galambos, T., Amin, S. S., Hampson, E., Mall Haidaraly, K., …Izzet, G. (2022). Supramolecular assemblies of organo-functionalised hybrid polyoxometalates: From functional building blocks to hierarchical nanomaterials. Chemical Society Reviews, 51(1), 293-328. https://doi.org/10.1039/d1cs00832c

This review provides a comprehensive overview of recent advances in the supramolecular organisation and hierarchical self-assembly of organo-functionalised hybrid polyoxometalates (hereafter referred to as hybrid POMs), and their emerging role as mul... Read More about Supramolecular assemblies of organo-functionalised hybrid polyoxometalates: From functional building blocks to hierarchical nanomaterials.

Site-Selective Installation of Nϵ-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C–C Bond Formation (2021)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E., Oldham, N. J., …Mitchell, N. J. (2022). Site-Selective Installation of Nϵ-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C–C Bond Formation. Angewandte Chemie International Edition, 61(2), Article e202110223. https://doi.org/10.1002/anie.202110223

Post-translational modifications (PTMs) enhance the repertoire of protein function and mediate or influence the activity of many cellular processes. The preparation of site-specifically and homogeneously modified proteins, to apply as tools to unders... Read More about Site-Selective Installation of Nϵ-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C–C Bond Formation.

Site‐Selective Installation of Nϵ ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation (2021)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., …Mitchell, N. J. (2022). Site‐Selective Installation of Nϵ ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation. Angewandte Chemie, 134(2), Article e202110223. https://doi.org/10.1002/ange.202110223

Post-translational modifications (PTMs) enhance the repertoire of protein function and mediate or influence the activity of many cellular processes. The preparation of site-specifically and homogeneously modified proteins, to apply as tools to unders... Read More about Site‐Selective Installation of Nϵ ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation.

Machine-Learning-Enabled Virtual Screening for Inhibitors of Lysine-Specific Histone Demethylase 1 (2021)
Journal Article
Zhou, J., Wu, S., Lee, B. G., Chen, T., He, Z., Lei, Y., …Hirst, J. D. (2021). Machine-Learning-Enabled Virtual Screening for Inhibitors of Lysine-Specific Histone Demethylase 1. Molecules, 26(24), Article 7492. https://doi.org/10.3390/molecules26247492

A machine learning approach has been applied to virtual screening for lysine specific demethylase 1 (LSD1) inhibitors. LSD1 is an important anti-cancer target. Machine learning models to predict activity were constructed using Morgan molecular finger... Read More about Machine-Learning-Enabled Virtual Screening for Inhibitors of Lysine-Specific Histone Demethylase 1.

An Expanded 2D Fused Aromatic Network with 90-Ring Hexagons (2021)
Journal Article
Riaño, A., Strutyński, K., Liu, M., Stoppiello, C. T., Lerma‐Berlanga, B., Saeki, A., …Mateo-Alonso, A. (2022). An Expanded 2D Fused Aromatic Network with 90-Ring Hexagons. Angewandte Chemie International Edition, 61(2), Article e202113657. https://doi.org/10.1002/anie.202113657

Two-dimensional fused aromatic networks (2D FANs) have emerged as a highly versatile alternative to holey graphene. The synthesis of 2D FANs with increasingly larger lattice dimensions will enable new application perspectives. However, the synthesis... Read More about An Expanded 2D Fused Aromatic Network with 90-Ring Hexagons.

Mimicking native display of cd0873 on liposomes augments its potency as an oral vaccine against clostridioides difficile (2021)
Journal Article
Karyal, C., Palazi, P., Hughes, J., Griffiths, R. C., Persaud, R. R., Tighe, P. J., …Griffin, R. (2021). Mimicking native display of cd0873 on liposomes augments its potency as an oral vaccine against clostridioides difficile. Vaccines, 9(12), Article 1453. https://doi.org/10.3390/vaccines9121453

Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA) antibody, which neutralises pathogens and enterotoxins by blocking their attachment to epithelial cells. We previously demonstrated that encapsulated protein antige... Read More about Mimicking native display of cd0873 on liposomes augments its potency as an oral vaccine against clostridioides difficile.

Mapping blood biochemistry by Raman spectroscopy at the cellular level (2021)
Journal Article
Volkov, V. V., McMaster, J., Aizenberg, J., & Perry, C. C. (2022). Mapping blood biochemistry by Raman spectroscopy at the cellular level. Chemical Science, 13(1), 133-140. https://doi.org/10.1039/d1sc05764b

We report how Raman difference imaging provides insight on cellular biochemistryin vivoas a function of sub-cellular dimensions and the cellular environment. We show that this approach offers a sensitive diagnostic to address blood biochemistry at th... Read More about Mapping blood biochemistry by Raman spectroscopy at the cellular level.

Publisher Correction: Visible light-driven conjunctive olefination (Nature Chemistry, (2022), 14, 1, (66-70), 10.1038/s41557-021-00807-x) (2021)
Journal Article
Filippini, D., & Silvi, M. (2021). Publisher Correction: Visible light-driven conjunctive olefination (Nature Chemistry, (2022), 14, 1, (66-70), 10.1038/s41557-021-00807-x). Nature Chemistry, 14(1), Article 110. https://doi.org/10.1038/s41557-021-00863-3

In the version of the article originally published, there was an error in Fig. 2d. Specifically, the first instance of what now reads as “PPh3Br” initially appeared as “PPh3BrH.” This has been corrected in the online version of the article.

A high-throughput, solvent free method for dispersing metal atoms directly onto supports (2021)
Journal Article
Kohlrausch, E. C., Centurion, H. A., Lodge, R. W., Luo, X., Slater, T., Santos, M. J. L., …Alves Fernandes, J. (2021). A high-throughput, solvent free method for dispersing metal atoms directly onto supports. Journal of Materials Chemistry A, 9(47), 26676-26679. https://doi.org/10.1039/d1ta08372d

Atomically-dispersed metal catalysts (ADMCs) on surfaces have demonstrated high activity and selectivity in many catalytic reactions. However, dispersing and stabilising individual atoms in support materials in an atom/energy-efficient scalable way s... Read More about A high-throughput, solvent free method for dispersing metal atoms directly onto supports.

Photoionization from the Xe 4d orbitals of XeF2 (2021)
Journal Article
Forbes, R., Hockett, P., Powis, I., Bozek, J. D., Holland, D. M., & Pratt, S. T. (2021). Photoionization from the Xe 4d orbitals of XeF2. Journal of Chemical Physics, 155(19), Article 194301. https://doi.org/10.1063/5.0068530

We present a comparison of the photoionization dynamics of the 4d shell of XeF2 from threshold to 250 eV to those of the prototypical 4d shell of atomic Xe. The new experimental data include spin-orbit and ligand-field-resolved partial cross sections... Read More about Photoionization from the Xe 4d orbitals of XeF2.