Skip to main content

Research Repository

Advanced Search

All Outputs (87)

The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review (2016)
Journal Article
Hakamy, A., Bolton, C. E., & McKeever, T. M. (2017). The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review. Chronic Respiratory Disease, 14(1), https://doi.org/10.1177/1479972316661925

Objectives: To evaluate the impact of pulmonary rehabilitation on survival and fall (including balance) in patients with chronic obstructive pulmonary disease (COPD) at stability. Design: Systematic Review. Methods: OVID, MEDLINE, EMBASE, and... Read More about The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review.

Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries (2016)
Journal Article
O'Dowd, E. L., Lüchtenborg, M., Baldwin, D. R., McKeever, T. M., Powell, H. A., Møller, H., …Hubbard, R. B. (2016). Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries. Lung Cancer, 95, https://doi.org/10.1016/j.lungcan.2016.03.002

Objectives: Current British guidelines advocate the use of risk prediction scores such as Thoracoscore to estimate mortality prior to radical surgery for non-small cell lung cancer (NSCLC). A recent publication used the National Lung Cancer Audit (NL... Read More about Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries.

Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers (2016)
Journal Article
Wilcock, A., Crosby, V., Hussain, A., McKeever, T. M., Manderson, C., Farnan, S., …Seymour, J. (2016). Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers. Respiratory Medicine, 114, 38-45. https://doi.org/10.1016/j.rmed.2016.03.006

Background In the UK, although 40% of patients with lung cancer are diagnosed following an emergency admission (EA), data is limited on their needs and experiences as they progress through diagnostic and treatment pathways. Methods Prospective... Read More about Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers.

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease (2016)
Journal Article
John, M., McKeever, T. M., Haddad, M. A., Hall, I. P., Sayers, I., Cockcroft, J. R., & Bolton, C. E. (2016). Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13(3), https://doi.org/10.1177/1479972316636995

With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 1... Read More about Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

The utility of exhaled nitric oxide in patients with suspected asthma (2016)
Journal Article
Martin, M., Wilson, E., Gerrard-Tarpey, W., Meakin, G., Hearson, G., McKeever, T., …Harrison, T. (2016). The utility of exhaled nitric oxide in patients with suspected asthma. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-208014

The value of FENO measurements in patients with symptoms suggestive of asthma is unclear. We performed an observational study to assess the ability of FENO to diagnose asthma and to predict response to inhaled corticosteroids (ICS). Our findings sugg... Read More about The utility of exhaled nitric oxide in patients with suspected asthma.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 (2016)
Journal Article
Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J., …Wain, L. V. (in press). Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-207876

Background Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants. Objective To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated... Read More about Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 (2015)
Journal Article
Hutchinson, J. P., Fogarty, A. W., McKeever, T. M., & Hubbard, R. B. (2016). In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. American Journal of Respiratory and Critical Care Medicine, 193(10), 1161-1167. https://doi.org/10.1164/rccm.201508-1632OC

Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader population... Read More about In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011.

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., …Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review (2015)
Journal Article
Hutchinson, J. P., Fogarty, A. W., Hubbard, R. B., & McKeever, T. M. (2015). Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. European Respiratory Journal, 46(3), https://doi.org/10.1183/09031936.00185114

Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the gl... Read More about Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.

Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study (2015)
Journal Article
Donaldson, J., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2015). Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study. Neurology, 84(18), https://doi.org/10.1212/WNL.0000000000001538

OBJECTIVES: Studies report that the risks of significant neurologic complications (including stroke, cerebral abscess, and migraine) and hemorrhagic sequelae are high in patients with hereditary hemorrhagic telangiectasia (HHT), and that life expe... Read More about Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study.

A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? (2015)
Journal Article
Barber, J., McKeever, T. M., McDowell, S. E., Clayton, J. A., Ferner, R. E., Gordon, R. D., …Glover, M. (2015). A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. British Journal of Clinical Pharmacology, 79(4), https://doi.org/10.1111/bcp.12499

Aims: Hyponatraemia is one of the major adverse effects of thiazide and thiazide-like diuretics and the leading cause of drug-induced hyponatraemia requiring hospital admission. We sought to review and analyze all published cases of this important co... Read More about A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?.

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study (2015)
Journal Article
Jenkins, R. G., Simpson, J. K., Saini, G., Bentley, J. H., Russell, A., Braybrooke, R., …Maher, T. M. (2015). Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study. Lancet Respiratory Medicine, 3(6), https://doi.org/10.1016/s2213-2600%2815%2900048-x

BACKGROUND: Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarkers of ther... Read More about Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.

?v?6 integrin may be a potential prognostic biomarker in interstitial lung disease (2015)
Journal Article
Saini, G., Porte, J., Weinreb, P. H., Violette, S. M., Wallace, W. A., McKeever, T. M., & Jenkins, G. (2015). ?v?6 integrin may be a potential prognostic biomarker in interstitial lung disease. European Respiratory Journal, 46(2), 486-494. https://doi.org/10.1183/09031936.00210414

Idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonitis are progressive interstitial lung diseases (ILDs) with limited treatment options and poor survival. However, the rate of disease progression is variable, implying t... Read More about ?v?6 integrin may be a potential prognostic biomarker in interstitial lung disease.

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., …Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND: There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK? (2014)
Journal Article
O'Dowd, E. L., McKeever, T. M., Baldwin, D. R., Anwar, S., Powell, H. A., Gibson, J. E., …Hubbard, R. B. (2015). What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?. Thorax, 70(2), https://doi.org/10.1136/thoraxjnl-2014-205692

Background: The UK has poor lung cancer survival rates and high early mortality, compared to other countries. We aimed to identify factors associated with early death, and features of primary care that might contribute to late diagnosis. Methods: Al... Read More about What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?.

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century (2014)
Journal Article
Hutchinson, J. P., McKeever, T. M., Fogarty, A. W., Navaratnam, V., & Hubbard, R. B. (2014). Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century. Annals of the American Thoracic Society, 11(8), https://doi.org/10.1513/AnnalsATS.201404-145OC

Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited. Objectives: We aimed to collate death certification data f... Read More about Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century.

Respiratory muscle specific warm-up and elite swimming performance (2014)
Journal Article
Wilson, E. E., McKeever, T. M., Lobb, C., Sherriff, T., Gupta, L., Hearson, G., …Shaw, D. E. (2014). Respiratory muscle specific warm-up and elite swimming performance. British Journal of Sports Medicine, 48(9), https://doi.org/10.1136/bjsports-2013-092523

Background: Inspiratory muscle training has been shown to improve performance in elite swimmers, when used as part of routine training, but its use as a respiratory warm-up has yet to be investigated. Aim: To determine the influence of inspiratory m... Read More about Respiratory muscle specific warm-up and elite swimming performance.

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction (2014)
Journal Article
Wain, L. V., Sayers, I., Soler Artigas, M., Portelli, M. A., Zeggini, E., Obeidat, M., …Tobin, M. D. (2014). Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction. PLoS Genetics, 10(5), Article e1004314. https://doi.org/10.1371/journal.pgen.1004314

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with l... Read More about Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction.