An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule
(2015)
Journal Article
Nigro, E., Colavita, I., Sarnataro, D., Scudiero, O., Zambrano, G., Granata, V., …Pessi, A. (2015). An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule. Scientific Reports, 5, Article 18450. https://doi.org/10.1038/srep18450
Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core motif”. We reasoned that for each HDPs evolved from an ancestral γ-core,... Read More about An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.