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The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum (2013)
Journal Article
Jabbari, S., Steiner, E., Heap, J. T., Winzer, K., Minton, N. P., & King, J. R. (2013). The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum. Mathematical Biosciences, 243(2), https://doi.org/10.1016/j.mbs.2013.03.005

The bacterium Clostridium acetobutylicum produces acids as an energy-yielding process during exponential growth. An acidic environment, however, is toxic to the cells and two survival mechanisms are in place to prevent them from dying. Firstly, durin... Read More about The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum.

Transgenic nematodes as biosensors for metal stress in soil pore water samples (2012)
Journal Article
Anbalagan, C., Lafayette, I., Antoniou-Kourounioti, M., Haque, M., King, J., Johnsen, B., …de Pomerai, D. (2012). Transgenic nematodes as biosensors for metal stress in soil pore water samples. Ecotoxicology, 21(2), https://doi.org/10.1007/s10646-011-0804-0

Caenorhabditis elegans strains carrying stress-reporter green fluorescent protein transgenes were used to explore patterns of response to metals. Multiple stress pathways were induced at high doses by most metals tested, including members of the heat... Read More about Transgenic nematodes as biosensors for metal stress in soil pore water samples.

Continuum limits of pattern formation in hexagonal-cell monolayers (2012)
Journal Article
O'Dea, R. D., & King, J. R. (2012). Continuum limits of pattern formation in hexagonal-cell monolayers. Journal of Mathematical Biology, 64(3), https://doi.org/10.1007/s00285-011-0427-3

Intercellular signalling is key in determining cell fate. In closely packed tissues such as epithelia, juxtacrine signalling is thought to be a mechanism for the generation of fine-grained spatial patterns in cell differentiation commonly observed in... Read More about Continuum limits of pattern formation in hexagonal-cell monolayers.

The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling (2011)
Journal Article
O'Dea, R. D., & King, J. R. (2013). The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling. Mathematical Medicine and Biology, 30(2), https://doi.org/10.1093/imammb/dqr028

Juxtacrine signalling mechanisms are known to be crucial in tissue and organ development, leading to spatial patterns in gene expression. We investigate the patterning behaviour of a discrete model of juxtacrine cell signalling due to Owen \& Sherrat... Read More about The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling.

Multiscale analysis of pattern formation via intercellular signalling (2011)
Journal Article
O'Dea, R. D., & King, J. R. (2011). Multiscale analysis of pattern formation via intercellular signalling. Mathematical Biosciences, 231(2), https://doi.org/10.1016/j.mbs.2011.03.003

Lateral inhibition, a juxtacrine signalling mechanism by which a cell adopting a particular fate inhibits neighbouring cells from doing likewise, has been shown to be a robust mechanism for the formation of fine-grained spatial patterns (in which adj... Read More about Multiscale analysis of pattern formation via intercellular signalling.

Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study (2010)
Journal Article
Twycross, J., Band, L. R., Bennett, M. J., King, J. R., & Krasnogor, N. (2010). Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study. BMC Systems Biology, 4, https://doi.org/10.1186/1752-0509-4-34

Background: Stochastic and asymptotic methods are powerful tools in developing multiscale systems biology models; however, little has been done in this context to compare the efficacy of these methods. The majority of current systems biology modellin... Read More about Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study.

A multiple timescale analysis of a mathematical model of the Wnt/?-catenin signalling pathway (2009)
Journal Article
Mirams, G. R., Byrne, H. M., & King, J. R. (2010). A multiple timescale analysis of a mathematical model of the Wnt/?-catenin signalling pathway. Journal of Mathematical Biology, 60(1), 131-160. https://doi.org/10.1007/s00285-009-0262-y

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. β-catenin is a protein that regulates both transcription of many genes and cell-cell... Read More about A multiple timescale analysis of a mathematical model of the Wnt/?-catenin signalling pathway.

Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells (2007)
Journal Article
van Leeuwen, I. M. M., Byrne, H. M., Jensen, O. E., & King, J. R. (2007). Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells. Journal of Theoretical Biology, 247(1), 77-102. https://doi.org/10.1016/j.jtbi.2007.01.019

Wnt signalling is involved in a wide range of physiological and pathological processes. The presence of an extracellular Wnt stimulus induces cytoplasmic stabilisation and nuclear translocation of beta-catenin, a protein that also plays an essential... Read More about Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells.