All Outputs (84)

Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings (2018)
Journal Article
Qureshi, N., Weng, S. F., Tranter, J. A., Da Silva, M. L., Kai, J., & Leonardi-Bee, J. (2018). Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings. Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012985

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The purpose of this review is to assess the effectiveness of interventions to systematically improve identification of FH in non-specialist settings compared t... Read More about Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2018)
Journal Article
Hussein, N., Weng, S. F., Kai, J., Kleijnen, J., & Qureshi, N. (2018). Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease. Cochrane Database of Systematic Reviews, 2015(8), doi:10.1002/14651858.CD010849.pub3

Background: Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rate... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Can machine-learning improve cardiovascular risk prediction using routine clinical data (2017)
Journal Article
Weng, S. F., Reps, J. M., Kai, J., Garibaldi, J. M., & Quereshi, N. (2017). Can machine-learning improve cardiovascular risk prediction using routine clinical data. PLoS ONE, 12(4), Article e0174944. https://doi.org/10.1371/journal.pone.0174944

Background Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. Machine-learning offers opportunity to improve accuracy by exploiti... Read More about Can machine-learning improve cardiovascular risk prediction using routine clinical data.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Little, I., Vinogradova, Y., Orton, E., Kai, J., & Qureshi, N. (2017). Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis. BMJ Open, 7(3), Article e012665. https://doi.org/10.1136/bmjopen-2016-012665

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE). Design: Cohort study with nested case-control analysis. Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

Obesity prevention and intervention: what's happening in the East Midlands? (2017)
Book
Cross-Bardell, L., Bird, L., Ward, D., & Kai, J. (2017). Obesity prevention and intervention: what's happening in the East Midlands?. East Midlands Academic Health Science Network

Facilitating access to obesity services for high risk, harder to reach groups: recent learning from the East Midlands region (UK) (2017)
Book
Bird, L., Cross-Bardell, L., Ward, D., & Kai, J. (2017). Facilitating access to obesity services for high risk, harder to reach groups: recent learning from the East Midlands region (UK). East Midlands Academic Health Science Network

Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care (2016)
Journal Article
Kai, J., Middleton, L., Daniels, J., Pattison, H., Tryposkiadis, K., & Gupta, J. (in press). Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care. British Journal of General Practice, 66(653), Article e861-e870. https://doi.org/10.3399/bjgp16X687577

Background: Heavy menstrual bleeding (HMB) is a common, chronic problem burdening women and health services. However long-term evidence on treatment in primary care is lacking. Aim: To assess the effectiveness of commencing levonorgestrel intra-ut... Read More about Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care.

Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study (2016)
Journal Article
Malins, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. K. (2016). Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study. British Journal of General Practice, 66(651), e729-e736. https://doi.org/10.3399/bjgp16X686569

Background: Most frequent attendance in primary care is temporary. Long-term frequent attendance may be suitable for psychological intervention to address health management and service use. Aim: To explore the feasibility and acceptability of cog... Read More about Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study.

Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study (2016)
Journal Article
Qureshi, N., Weng, S., Tranter, J., El-Kadiki, A., & Kai, J. (2016). Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study. BMJ Open, 6, Article e011734. https://doi.org/10.1136/bmjopen-2016-011734

Objectives: To assess the feasibility of improving identification of familial hypercholesterolaemia (FH) in primary care, and of collecting outcome measures to inform a future trial. Design: Feasibility intervention study. Setting: 6 general practi... Read More about Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study.

Influence of clinical communication on parents’ antibiotic expectations for children with respiratory tract infections (2016)
Journal Article
Cabral, C., Ingram, J., Lucas, P. J., Redmond, N. M., Kai, J., Hay, A. D., & Horwood, J. (2016). Influence of clinical communication on parents’ antibiotic expectations for children with respiratory tract infections. Annals of Family Medicine, 14(2), 141-147. https://doi.org/10.1370/afm.1892

Sensitivity to scale of willingness-to-pay within the context of menorrhagia (2016)
Journal Article
Sanghera, S., Frew, E., Gupta, J. K., Kai, J., & Roberts, T. E. (2017). Sensitivity to scale of willingness-to-pay within the context of menorrhagia. Health Expectations, 20(2), https://doi.org/10.1111/hex.12452

Objectives: Willingness-to-pay (WTP) provides a broad assessment of well-being, capturing benefits beyond health. However, the validity of the approach has been questioned and the evidence relating to the sensitivity of WTP to changes in health statu... Read More about Sensitivity to scale of willingness-to-pay within the context of menorrhagia.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., …Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Clinical characteristics of persistent frequent attenders in primary care: case–control study (2015)
Journal Article
Patel, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. (2015). Clinical characteristics of persistent frequent attenders in primary care: case–control study. Family Practice, cmv076. https://doi.org/10.1093/fampra/cmv076

Background. Most frequent attendance in primary care is temporary, but persistent frequent attendance is expensive and may be suitable for psychological intervention. To plan appropriate intervention and service delivery, there is a need for research... Read More about Clinical characteristics of persistent frequent attenders in primary care: case–control study.

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: The ECLIPSE trial (2015)
Journal Article
Gupta, J. K., Daniels, J. P., Middleton, L. J., Pattison, H. M., Prileszky, G., Roberts, T. E., …Kai, J. (2015). A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: The ECLIPSE trial. Health Technology Assessment, 19(88), 1-118. https://doi.org/10.3310/hta19880

© Queen’s Printer and Controller of HMSO 2015. Background: Heavy menstrual bleeding (HMB) is a common problem, yet evidence to inform decisions about initial medical treatment is limited. Objectives: To assess the clinical effectiveness and cost-effe... Read More about A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: The ECLIPSE trial.

Synthesis of UK evidence based recommendations for adult obesity prevention and treatment for service improvement and implementation: why weight? East Midlands Academic Health Science Network Obesity Programme (2015)
Report
Bird, L., Cross-Bardell, L., Ward, D., & Kai, J. (2015). Synthesis of UK evidence based recommendations for adult obesity prevention and treatment for service improvement and implementation: why weight? East Midlands Academic Health Science Network Obesity Programme

Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia (2015)
Journal Article
Sanghera, S., Frew, E., Gupta, J. K., Kai, J., & Roberts, T. E. (2015). Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia. PharmacoEconomics, 33(9), https://doi.org/10.1007/s40273-015-0280-0

Background: The extra-welfarist theoretical framework tends to focus on health-related quality of life, whilst the welfarist framework captures a wider notion of well-being. EQ-5D and SF-6D are commonly used to value outcomes in chronic conditions wi... Read More about Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia.

Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study (2015)
Journal Article
Qureshi, N., Kai, J., Middlemass, J., Dhiman, P., Cross-Bardell, L., Acharya, J., …Standen, P. (2015). Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study. Primary Health Care Research and Development, 16(6), 607-617. https://doi.org/10.1017/S1463423615000122

Aim: This study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to participants. Background: Coronary heart disease (CHD) genetic... Read More about Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study.

Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study (2015)
Journal Article
Cross-Bardell, L., George, T., Bhoday, M., Tuomainen, H., Qureshi, N., & Kai, J. (2015). Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study. BMJ Open, 5(2), Article e007317. https://doi.org/10.1136/bmjopen-2014-007317

Objectives To explore perspectives on enhancing physical activity and diet among South Asians in urban deprived communities at high risk of chronic disease and to inform development of culturally appropriate health promotion intervention. Des... Read More about Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study.

Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT) (2014)
Journal Article
Weng, S. F., Kai, J., Neil, H. A., Humphries, S. E., & Qureshi, N. (2015). Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT). Atherosclerosis, 238(2), https://doi.org/10.1016/j.atherosclerosis.2014.12.034

Objective: Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant disorder. The vast majority of affected individuals remain undiagnosed, resulting in lost opportunities for preventing premature heart disease. Better use of r... Read More about Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT).

Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening (2014)
Journal Article
Qureshi, N., Ulph, F., Cullinan, T., & Kai, J. (2015). Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening. European Journal of Human Genetics, 23(4), 459–465. https://doi.org/10.1038/ejhg.2014.126

Universal newborn screening for sickle cell disorders and cystic fibrosis aims to enable the early identification and treatment of affected babies. Screening can also identify infants who are healthy carriers, with carrier results being the commonest... Read More about Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening.