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Rapid conversion of highly porous borate glass microspheres into hydroxyapatite (2021)
Journal Article
Islam, M. T., Macri-Pellizzeri, L., Sottile, V., & Ahmed, I. (2021). Rapid conversion of highly porous borate glass microspheres into hydroxyapatite. Biomaterials Science, https://doi.org/10.1039/d0bm01776k

This paper reports on the rapid development of porous hydroxyapatite (HA) microspheres with large external pores and fully interconnected porosity. These porous microspheres were produced by converting borates glasses (namely 45B5, B53P4 and 13-93B)... Read More about Rapid conversion of highly porous borate glass microspheres into hydroxyapatite.

The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It (2020)
Journal Article
Keidser, G., Naylor, G., Brungart, D., Caduff, A., Campos, J., Carlile, S., …Smeds, K. (2020). The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It. Ear and Hearing, 41(Supplement 1), 5S-19S. https://doi.org/10.1097/AUD.0000000000000944

Ecological validity is a relatively new concept in hearing science. It has been cited as relevant with increasing frequency in publications over the past 20 years, but without any formal conceptual basis or clear motive. The sixth Eriksholm Workshop... Read More about The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It.

Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma (2020)
Journal Article
McCrorie, P., Vasey, C. E., Smith, S. J., Marlow, M., Alexander, C., & Rahman, R. (2020). Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma. Journal of Controlled Release, 328, 917-931. https://doi.org/10.1016/j.jconrel.2020.11.022

© 2020 We review the challenges of next-generation therapeutics for both systemic and localised delivery to brain tumours and discuss how recent engineering advances may be used to enhance brain penetration of systemic delivery therapies. The unmet c... Read More about Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma.

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis (2020)
Journal Article
Meng, D., Welton, T., Elsarraj, A., Morgan, P. S., das Nair, R., Constantinescu, C. S., …Dineen, R. A. (2020). Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis. Human Brain Mapping, https://doi.org/10.1002/hbm.25239

Fasting and surgery timing (FaST) audit (2020)
Journal Article
El-Sharkawy, A. M., Daliya, P., Lewis-Lloyd, C., Adiamah, A., Malcolm, F. L., Boyd-Carson, H., …Wolff, J. (2021). Fasting and surgery timing (FaST) audit. Clinical Nutrition, 40(3), 1405-1412. https://doi.org/10.1016/j.clnu.2020.08.033

Background & aims International guidance advocates the avoidance of prolonged preoperative fasting due to its negative impact on perioperative hydration. This study aimed to assess the adherence to these guidelines for fasting in patients undergoi... Read More about Fasting and surgery timing (FaST) audit.

Insights into conducting audiological research with clinical databases (2020)
Journal Article
Dillard, L. K., Saunders, G. H., Zobay, O., & Naylor, G. (2020). Insights into conducting audiological research with clinical databases. American Journal of Audiology, 29(3S), 676-681. https://doi.org/10.1044/2020_AJA-19-00067

The clinical data stored in electronic health records (EHRs) provide unique opportunities for audiological clinical research. In this viewpoint article, we share insights from our experience of working with a large clinical database of over 730,00... Read More about Insights into conducting audiological research with clinical databases.

Effect of short-term integrated palliative care on patient-reported outcomes among people with advanced long-term neurological conditions : A randomized clinical trial (2020)
Journal Article
Gao, W., Wilson, R., Hepgul, N., Yi, D., Evans, C., Bajwah, S., …Higginson, I. J. (2020). Effect of short-term integrated palliative care on patient-reported outcomes among people with advanced long-term neurological conditions : A randomized clinical trial. JAMA Network Open, 3(8), Article e2015061. https://doi.org/10.1001/jamanetworkopen.2020.15061

Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier (2020)
Journal Article
Alelwani, W., Elmorsy, E., Kattan, S. W., Babteen, N. A., Alnajeebi, A. M., Al-Ghafari, A., & Carter, W. G. (2020). Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier. Toxicology Letters, 333, 184-191. https://doi.org/10.1016/j.toxlet.2020.08.006

Carbamazepine (CBZ) is a widely employed anti-seizure medication that crosses the blood-brain barrier (BBB) to exert its anti-convulsant action. The effects of CBZ on components of the BBB have yet to be completely delineated. Hence the current study... Read More about Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier.

Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets (2020)
Journal Article
Kurozumi, S., Alsaleem, M., Monteiro, C. J., Bhardwaj, K., Joosten, S. E., Fujii, T., …Johnston, S. J. (2020). Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets. Breast Cancer Research, 22, Article 85. https://doi.org/10.1186/s13058-020-01324-4

© 2020 The Author(s). Background: Invasive lobular carcinoma (ILC) accounts for 10-15% of primary breast cancers and is typically estrogen receptor alpha positive (ER+) and ERBB2 non-amplified. Somatic mutations in ERBB2/3 are emerging as a tractable... Read More about Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.

Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy (2020)
Journal Article
Bass, J. J., Nakhuda, A., Deane, C. S., Brook, M. S., Wilkinson, D. J., Phillips, B. E., …Atherton, P. J. (2020). Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy. Molecular Metabolism, 42, Article 101059. https://doi.org/10.1016/j.molmet.2020.101059

Objective The Vitamin D receptor (VDR) has been positively associated with skeletal muscle mass, function and regeneration. Mechanistic studies have focused upon loss of the receptor, with in vivo whole-body knockout models demonstrating reduced myo... Read More about Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy.

Covid-19 Lockdown Affects Hearing Disability and Handicap in Diverse Ways: A Rapid Online Survey Study (2020)
Journal Article
Naylor, G., Burke, L., & Holman, J. (2020). Covid-19 Lockdown Affects Hearing Disability and Handicap in Diverse Ways: A Rapid Online Survey Study. Ear and Hearing, 41(6), 1442-1449. https://doi.org/10.1097/AUD.0000000000000948

Objectives: The aim of this study was to explore the perceived effects of Covid-19 social distancing restrictions and safety measures on people with hearing loss. Design: Participants were 129 adults (48.1% female, mean age 64.4 years) wit... Read More about Covid-19 Lockdown Affects Hearing Disability and Handicap in Diverse Ways: A Rapid Online Survey Study.

The Effect of Hearing Loss and Hearing Device Fitting on Fatigue in Adults: A Systematic Review (2020)
Journal Article
Holman, J. A., Drummond, A., & Naylor, G. (2021). The Effect of Hearing Loss and Hearing Device Fitting on Fatigue in Adults: A Systematic Review. Ear and Hearing, 42(1), 1-11

Objectives: To conduct a systematic review to address two research questions: (Q1) Does hearing loss have an effect on fatigue? (Q2) Does hearing device fitting have an effect on fatigue? It was hypothesized that hearing loss would increase fatigue... Read More about The Effect of Hearing Loss and Hearing Device Fitting on Fatigue in Adults: A Systematic Review.

An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification (2020)
Journal Article
Millar, S. A., John, S. G., McIntyre, C. W., Ralevic, V., Anderson, S. I., & O'Sullivan, S. E. (2020). An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification. Frontiers in Endocrinology, 11, https://doi.org/10.3389/fendo.2020.00369

© Copyright © 2020 Millar, John, McIntyre, Ralevic, Anderson and O'Sullivan. Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD)... Read More about An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification.

A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion (2020)
Journal Article
Canales Coutino, B., Cornhill, Z. E., Couto, A., Mack, N. A., Rusu, A. D., Nagarajan, U., …Georgiou, M. (2020). A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion. iScience, 23(6), Article 101237. https://doi.org/10.1016/j.isci.2020.101237

© 2020 The Authors Metastasis is the leading cause of death for patients with cancer. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumor growth toward malignancy. Advances in... Read More about A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion.

Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing (2020)
Journal Article
Astbury, S., Nunes Soares, M. M. D. C., Peprah, E., King, B., Jardim, A. C. G., Shimizu, J. F., …McClure, P. (2020). Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing. Journal of Clinical Virology, 129, Article 104483. https://doi.org/10.1016/j.jcv.2020.104483

© 2020 Background: Effective drug regimens for the treatment of hepatitis B virus (HBV) infections are essential to achieve the World Health Organisation commitment to eliminate viral hepatitis by 2030. Lamivudine (3TC) is widely used in countries wi... Read More about Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing.