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All Outputs (485)

Metabolic modeling-based drug repurposing in Glioblastoma (2022)
Journal Article
Tomi-Andrino, C., Pandele, A., Winzer, K., King, J., Rahman, R., & Kim, D. (2022). Metabolic modeling-based drug repurposing in Glioblastoma. Scientific Reports, 12, Article 11189. https://doi.org/10.1038/s41598-022-14721-w

The manifestation of intra- and inter-tumor heterogeneity hinders the development of ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type. Specifically, the reprogramming of cellular metabolism has been identified as a... Read More about Metabolic modeling-based drug repurposing in Glioblastoma.

Wheeze in the time of COVID-19: overcoming obstacles to an unusual diagnosis (2022)
Journal Article
Barclay, M., Buderi, S., Bush, A., Daniel, M., Jordan, S., Rice, A., …Smyth, A. R. (2022). Wheeze in the time of COVID-19: overcoming obstacles to an unusual diagnosis. Thorax, 77(10), 1050-1053. https://doi.org/10.1136/thoraxjnl-2021-218526

This case is an example of a rare cause of a common clinical presentation (persistent lobar collapse with wheeze). We describe patient management from primary care through to a national thoracic referral centre. We highlight the importance of objecti... Read More about Wheeze in the time of COVID-19: overcoming obstacles to an unusual diagnosis.

Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion (2022)
Journal Article
Bishop, E., Dimitrova, M., Froggatt, A., Estevez-Cebrero, M., Storer, L. C. D., Mussai, F., …Dandapani, M. (2022). Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion. BioMed Research International, 2022, Article 9008685. https://doi.org/10.1155/2022/9008685

Despite significant improvements in treatment and survival in paediatric cancers, outcomes for children with brain tumours remain poor. Novel therapeutic approaches are needed to improve survival and quality of survival. Extracellular arginine depend... Read More about Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion.

EPCT-03. Working together to accelerate the preclinical to clinical translation of drug delivery systems for children’s brain tumours (2022)
Journal Article
Campbell, E., Aquilina, K., Dandapani, M., Walker, D., & Rahman, R. (2022). EPCT-03. Working together to accelerate the preclinical to clinical translation of drug delivery systems for children’s brain tumours. Neuro-Oncology, 24(Supplement 1), i36-i36. https://doi.org/10.1093/neuonc/noac079.131

Children's brain tumours are the biggest cancer killer in children and young adults. Several techniques, such as intra-cerebrospinal fluid chemotherapy, ultrasound-mediated blood-brain barrier disruption, convection enhanced delivery, polymer deliver... Read More about EPCT-03. Working together to accelerate the preclinical to clinical translation of drug delivery systems for children’s brain tumours.

EPEN-21. Developing a sensitive method for detection of minimal residual disease in ependymoma using metabolomic analysis of cerebrospinal fluid (2022)
Journal Article
Woodward, A., Amugi, L., Patel, K., Kilpatrick, C., Kim, D., & Dandapani, M. (2022). EPEN-21. Developing a sensitive method for detection of minimal residual disease in ependymoma using metabolomic analysis of cerebrospinal fluid. Neuro-Oncology, 24(Supplement 1), i43-i43. https://doi.org/10.1093/neuonc/noac079.719

Ependymoma (EPN) is the second most common malignant paediatric brain tumour with poor survival and significant neuro-cognitive impairment from current treatments (surgery and radiotherapy). Relapse occurs in 50% of patients within 2 years, despite n... Read More about EPEN-21. Developing a sensitive method for detection of minimal residual disease in ependymoma using metabolomic analysis of cerebrospinal fluid.

Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol (2022)
Journal Article
Leblond, P., Massimino, M., English, M., Ritzmann, T. A., Gandola, L., Calaminus, G., …Frappaz, D. (2022). Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol. Frontiers in Neurology, 13, Article 887544. https://doi.org/10.3389/fneur.2022.887544

Background: The clinical management of ependymoma in childhood and adolescence is complex and the clinicobiopathological correlates of outcome remain poorly understood. This international SIOP Ependymoma II (SIOP EPII) trial aims to improve the outco... Read More about Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol.

Industry influence in healthcare harms patients: myth or maxim? (2022)
Journal Article
Trayer, J., Rowbotham, N. J., Boyle, R. J., & Smyth, A. R. (2022). Industry influence in healthcare harms patients: myth or maxim?. Breathe, 18(2), Article 220010. https://doi.org/10.1183/20734735.0010-2022

Healthcare is a major global industry accounting for a significant proportion of government spending. Drug and medical device manufacturers are publicly traded companies with a responsibility to their shareholders to maximise profits by increasing sa... Read More about Industry influence in healthcare harms patients: myth or maxim?.

Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic (2022)
Journal Article
Hanley, S. J., Jones, A. B., Oberman, J., Baxter, E., Sharkey, D., Gray, J., & Walker, K. F. (2022). Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.018

Background: This study aimed to explore the successes and barriers to the implementation of Public Health England (PHE) infection prevention and control guidance in English maternity units during the COVID-19 pandemic. Methods: Qualitative semi-struc... Read More about Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic.

Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice (2022)
Journal Article
Hanley, S., Raybould, G., Baxter, E., Gray, J., Sharkey, D., & Walker, K. F. (2022). Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.019

Introduction: The rapidly evolving COVID-19 pandemic required systemic change in how healthcare was delivered to minimize virus transmission whilst maintaining safe service delivery. Deemed at ‘moderate-high risk’, maternity patients are an important... Read More about Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice.

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT (2022)
Journal Article
Maheshwari, A., Bari, V., Bell, J. L., Bhattacharya, S., Bhide, P., Bowler, U., …Troup, S. (2022). Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT. Health Technology Assessment, 26(25), 1-142. https://doi.org/10.3310/AEFU1104

Background Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisa... Read More about Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT.

Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening (2022)
Journal Article
Schiemer, R., Furniss, D., Phang, S., Seddon, A. B., Atiomo, W., & Gajjar, K. B. (2022). Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening. International Journal of Molecular Sciences, 23(9), Article 4859. https://doi.org/10.3390/ijms23094859

Endometrial cancer (EC) is the sixth most common cancer and the fourth leading cause of death among women worldwide. Early detection and treatment are associated with a favourable prognosis and reduction in mortality. Unlike other common cancers, how... Read More about Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening.

Application and potential of artificial intelligence in neonatal medicine (2022)
Journal Article
Chang Kwok, T., Henry, C., Saffaran, S., Meeus, M., Bates, D., Van Laere, D., …Sharkey, D. (2022). Application and potential of artificial intelligence in neonatal medicine. Seminars in Fetal and Neonatal Medicine, 27(5), Article 101346. https://doi.org/10.1016/j.siny.2022.101346

Neonatal care is becoming increasingly complex with large amounts of rich, routinely recorded physiological, diagnostic and outcome data. Artificial intelligence (AI) has the potential to harness this vast quantity and range of information and become... Read More about Application and potential of artificial intelligence in neonatal medicine.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article
Mistry, A., Shipley, L., Ojha, S., & Sharkey, D. (2022). Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(6), 597-602. https://doi.org/10.1136/archdischild-2021-322906

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04) (2022)
Journal Article
Apps, J. R., Maycock, S., Ellison, D. W., Jaspan, T., Ritzmann, T. A., Macarthur, D., …Picton, S. (2022). Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04). Neuro-Oncology Advances, 4(1), Article vdac053. https://doi.org/10.1093/noajnl/vdac053

Background Relapsed ependymoma has a dismal prognosis, and the role of chemotherapy at relapse remains unclear. This study prospectively evaluated the efficacy of intensive intravenous (IV) etoposide in patients less than 21 years of age with relaps... Read More about Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04).

Impacted fetal head during second stage Caesarean birth: A prospective observational study (2022)
Journal Article
Wyn Jones, N., Mitchell, E. J., Wakefield, N., Knight, M., Dorling, J., Thornton, J. G., & Walker, K. F. (2022). Impacted fetal head during second stage Caesarean birth: A prospective observational study. European Journal of Obstetrics and Gynecology and Reproductive Biology, 272, 77-81. https://doi.org/10.1016/j.ejogrb.2022.03.004

Objective: To determine the incidence of, and complication rates from, impacted fetal head at full dilatation Caesarean birth in the UK, and record what techniques were used. Design: Prospective observational study using the UK Obstetric Surveillance... Read More about Impacted fetal head during second stage Caesarean birth: A prospective observational study.

Detection of Label-Free Drugs within Brain Tissue Using Orbitrap Secondary Ion Mass Spectrometry as a Complement to Neuro-Oncological Drug Delivery (2022)
Journal Article
McCrorie, P., Rowlinson, J., Scurr, D. J., Marlow, M., & Rahman, R. (2022). Detection of Label-Free Drugs within Brain Tissue Using Orbitrap Secondary Ion Mass Spectrometry as a Complement to Neuro-Oncological Drug Delivery. Pharmaceutics, 14(3), Article 571. https://doi.org/10.3390/pharmaceutics14030571

Historically, pre-clinical neuro-oncological drug delivery studies have exhaustively relied upon overall animal survival as an exclusive measure of efficacy. However, with no adopted methodology to both image and quantitate brain parenchyma penetrati... Read More about Detection of Label-Free Drugs within Brain Tissue Using Orbitrap Secondary Ion Mass Spectrometry as a Complement to Neuro-Oncological Drug Delivery.

The natural history of ataxia-telangiectasia (A-T): A systematic review (2022)
Journal Article
Petley, E., Yule, A., Alexander, S., Ojha, S., & Whitehouse, W. P. (2022). The natural history of ataxia-telangiectasia (A-T): A systematic review. PLoS ONE, 17(3), Article e0264177. https://doi.org/10.1371/journal.pone.0264177

Background: Ataxia-telangiectasia is an autosomal recessive, multi-system, and life-shortening disease caused by mutations in the ataxia-telangiectasia mutated gene. Although widely reported, there are no studies that give a comprehensive picture of... Read More about The natural history of ataxia-telangiectasia (A-T): A systematic review.

What is new in migraine management in children and young people? (2022)
Journal Article
Loh, N. R., Whitehouse, W. P., & Howells, R. (2022). What is new in migraine management in children and young people?. Archives of Disease in Childhood, 107(12), 1067-1072. https://doi.org/10.1136/archdischild-2021-322373

For this narrative review, we found recent publications on the use and effectiveness of old therapies including nutraceuticals, such as riboflavin, vitamin D, magnesium, melatonin and talking therapies.Recent large trials of established conventional... Read More about What is new in migraine management in children and young people?.