Skip to main content

Research Repository

Advanced Search

All Outputs (1362)

The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence (2023)
Journal Article
Liang, Q. L., Nie, L. B., Elsheikha, H. M., Li, T. T., Sun, L. X., Zhang, Z. W., …Wang, J. L. (2023). The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence. PLoS Pathogens, 19(12), Article e1011831. https://doi.org/10.1371/journal.ppat.1011831

Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation, tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein phosphatase 6 (TgPP6) subunits of T. gondii and elucidate their... Read More about The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence.

Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. (2023)
Journal Article
Leach, K. A., Holsey, H. J., Bradley, A. J., & Green, M. J. (2023). Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. Veterinary Record, Article e3605. https://doi.org/10.1002/vetr.3605

Background: Achieving a reduction in mastitis in dairy cows is a common industry goal, but there is no recent peer-reviewed record of progress in the UK. Methods: A convenience sample of 125 herds in England and Scotland was recruited based on the qu... Read More about Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021..

The splicing factor SR2 is an important virulence factor of Toxoplasma gondii (2023)
Journal Article
Wu, X., Nanzheng, X., Elsheikha, H. M., Li, T., Kou, Y., & Zhu, X. (2023). The splicing factor SR2 is an important virulence factor of Toxoplasma gondii. Frontiers in Microbiology, 14, Article 1302512. https://doi.org/10.3389/fmicb.2023.1302512

Serine/arginine-rich (SR) proteins are key factors with important roles in constitutive and alternative splicing (AS) of pre-mRNAs. However, the role of SR splicing factors in the pathogenicity of T. gondii remains largely unexplored. Here, we invest... Read More about The splicing factor SR2 is an important virulence factor of Toxoplasma gondii.

Incorporating biodiversity responses to land use change scenarios for preventing emerging zoonotic diseases in areas of unknown host-pathogen interactions (2023)
Journal Article
Roque, F. D. O., Bellón, B., Guerra, A., Valente-Neto, F., Santos, C. C., Melo, I., …Ochoa-Quintero, J. M. (2023). Incorporating biodiversity responses to land use change scenarios for preventing emerging zoonotic diseases in areas of unknown host-pathogen interactions. Frontiers in Veterinary Science, 10, Article 1229676. https://doi.org/10.3389/fvets.2023.1229676

The need to reconcile food production, the safeguarding of nature, and the protection of public health is imperative in a world of continuing global change, particularly in the context of risks of emerging zoonotic disease (EZD). In this paper, we ex... Read More about Incorporating biodiversity responses to land use change scenarios for preventing emerging zoonotic diseases in areas of unknown host-pathogen interactions.

Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study (2023)
Journal Article
Gibson, J., Brennan, M. L., Oxtoby, C., Mossop, L., & White, K. (2023). Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study. Veterinary Record, 193(12), Article e3601. https://doi.org/10.1002/vetr.3601

Background Understanding ethical challenges experienced in relation to adverse events is necessary to inform strategies that optimise patient safety and practitioner wellbeing. Methods A qualitative exploration of UK veterinary practitioners’ ex... Read More about Ethical challenges experienced by veterinary practitioners in relation to adverse events: Insights from a qualitative study.

Pseudomonas spp. in Canine Otitis Externa (2023)
Journal Article
Secker, B., Shaw, S., & Atterbury, R. J. (2023). Pseudomonas spp. in Canine Otitis Externa. Microorganisms, 11(11), Article 2650. https://doi.org/10.3390/microorganisms11112650

Canine otitis externa (OE) is a commonly diagnosed condition seen in veterinary practice worldwide. In this review, we discuss the mechanisms of the disease, with a particular focus on the biological characteristics of Pseudomonas aeruginosa and the... Read More about Pseudomonas spp. in Canine Otitis Externa.

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., …Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection (2023)
Journal Article
Occhiuto, F., Vázquez-Diosdado, J. A., King, A. J., & Kaler, J. (2023). Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection. Scientific Reports, 13, Article 18243. https://doi.org/10.1038/s41598-023-44957-z

Individual consistency in behaviour, known as animal personality, and behavioural plasticity in response to environmental changes are important factors shaping individual behaviour. Correlations between them, called personality-dependent plasticity,... Read More about Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection.

A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii (2023)
Journal Article
Zheng, X., Sun, L., Elsheikha, H. M., Li, T., Gao, J., Wu, X., …Wang, J. (2024). A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii. International Journal for Parasitology, 54(2), 109-121. https://doi.org/10.1016/j.ijpara.2023.09.001

Pathogenicity of the zoonotic pathogen Toxoplasma gondii largely depends on the secretion of effector proteins into the extracellular milieu and host cell cytosol, including the dense granule proteins (GRAs). The protein-encoding gene TGME49_299780 w... Read More about A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii.

Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers (2023)
Journal Article
Doidge, C., Palczynski, L., Zhou, X., Bearth, A., van Schaik, G., & Kaler, J. (2023). Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers. Preventive Veterinary Medicine, 220, Article 106030. https://doi.org/10.1016/j.prevetmed.2023.106030

Appropriate management decisions are key for sustainable and profitable beef and dairy farming. Data-driven technologies aim to provide information which can improve farmers’ decision-making practices. However, data-driven technologies have resulted... Read More about Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers.

Antiviral activity of salt-coated materials against SARS-CoV-2 (2023)
Journal Article
Coleman, C. M., Wang, B., Wang, Y., Tapia-Brito, E., Chen, Z., Riffat, J., …Ghaemmaghami, A. (2023). Antiviral activity of salt-coated materials against SARS-CoV-2. Access Microbiology, 5(9), Article 000492. https://doi.org/10.1099/acmi.0.000492.v5

The SARS-CoV-2 pandemic demonstrated the importance of human coronaviruses and the need to develop materials to prevent the spread of emergent respiratory viruses. Coating of surfaces with antiviral materials is a major interest in controlling spread... Read More about Antiviral activity of salt-coated materials against SARS-CoV-2.

Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions (2023)
Journal Article
Dlamini, S. B., Gigante, A. M., Hooton, S. P. T., & Atterbury, R. J. (2023). Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions. Microorganisms, 11(10), Article 2389. https://doi.org/10.3390/microorganisms11102389

Salmonella causes a range of diseases in humans and livestock of considerable public health and economic importance. Widespread antimicrobial use, particularly in intensively produced livestock (e.g., poultry and pigs) may contribute to the rise of m... Read More about Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions.

Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level (2023)
Journal Article
Atallah, N. M., Alsaleem, M., Toss, M. S., Mongan, N. P., & Rakha, E. (2023). Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level. British Journal of Cancer, https://doi.org/10.1038/s41416-023-02426-4

Background: Increasing data indicate that HER2-positive (HER2 +) breast cancer (BC) subtypes exhibit differential responses to targeted anti-HER2 therapy. This study aims to investigate these differences and the potential underlying molecular mechani... Read More about Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level.

Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses (2023)
Journal Article
Mohd Jaafar, F., Belhouchet, M., Monsion, B., Bell-Sakyi, L., Mertens, P. P. C., & Attoui, H. (2023). Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses. Viruses, 15(9), Article 1908. https://doi.org/10.3390/v15091908

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the inter... Read More about Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.

Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study (2023)
Journal Article
Nunney, E., Crotta, M., van Winden, S., Bond, K., Green, M., & Guitian, J. (2023). Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study. Preventive Veterinary Medicine, 219, Article 106022. https://doi.org/10.1016/j.prevetmed.2023.106022

Johne's disease (JD) is a chronic disease of ruminants endemic in the UK and other countries and responsible for large economic losses for the dairy sector. JD is caused by Mycobacterium avium subspecies paratuberculosis (MAP), which typically infect... Read More about Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study.

Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display (2023)
Book Chapter
Tsoumpeli, M. T., Varghese, A., Owen, J. P., Maddison, B. C., Daly, J. M., & Gough, K. C. (2023). Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display. In M. Hust, & T. S. Lim (Eds.), Phage Display (467-487). Springer US. https://doi.org/10.1007/978-1-0716-3381-6_25

Peptide phage display has historically been used to epitope map monoclonal antibodies. More recently, by coupling this method with next-generation sequencing (so-called next-generation phage display, NGPD) to mass screen peptide binding events, the m... Read More about Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display.

Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets (2023)
Journal Article
Sun, H., Li, H., Tong, Q., Han, Q., Liu, J., Yu, H., …Liu, J. (2023). Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. Cell, 186(19), 4074-4084.e11. https://doi.org/10.1016/j.cell.2023.08.011

H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses are widespread in chicken flocks; however, the zoonotic features of H3N8 viruses are poorly understood... Read More about Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets.

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep (2023)
Journal Article
Evans, N. P., Bellingham, M., Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D., & Padmanabhan, V. (2023). Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology, 102, Article 104257. https://doi.org/10.1016/j.etap.2023.104257

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed t... Read More about Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.