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The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing (2018)
Journal Article
Labisso, W., Raulin, A., Nwidu, L., Kocon, A., Wayne, D., Erdozain, A., …Carter, W. (2018). The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing. Brain Sciences, 8(9), Article 175. https://doi.org/10.3390/brainsci8090175

Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals w... Read More about The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing.

Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae) (2018)
Journal Article
Lucky, L., Yibali, O., Ekramy, E., & Wayne, C. (2018). Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae). Journal of Basic and Clinical Physiology and Pharmacology, 29(6), 609-619. https://doi.org/10.1515/jbcpp-2017-0058

Background Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims. Methods A hepato-protective role of G. brevis hydromet... Read More about Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae).

In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., Aprioku, J., Siminialayi, I., & Carter, W. (2018). In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria. Medicines, 5(3), Article 71. https://doi.org/10.3390/medicines5030071

This study evaluated Moringa oleifera extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of Moringa oleifera were evaluated for inhibition of acetylcholin... Read More about In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria.

Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress (2018)
Journal Article
Nwidu, L. L., Oboma, Y. I., Elmorsy, E., & Carter, W. G. (2018). Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress. Journal of Taibah University Medical Sciences, 13(4), https://doi.org/10.1016/j.jtumed.2018.04.006

Objective: Natural antioxidant products are gaining popularity as treatments for various pathological liver injuries. Musanga cecropioides (Urticaceae) leaf extract is used in ethnomedicine for the management of jaundice and other hepatic ailments in... Read More about Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress.

In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., & Carter, W. (2018). In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria. Malaysian Journal of Medical Sciences, 25(2), https://doi.org/10.21315/mjms2018.25.2.4

Background: Polyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases and anti-oxidant properties. Methods: Anti-cholinesterase, anti-oxidant, and total phenolic and f... Read More about In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria.

Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., Yibala, O. I., & Carter, W. (2018). Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity. Journal of Taibah University Medical Sciences, 13(3), https://doi.org/10.1016/j.jtumed.2018.03.006

Objective Spondias mombin L. is a tree used in folk medicine in Nigeria for the treatment of hepatitis. This study was carried out to comparatively evaluate the hepatoprotective and antioxidant effects of S. mombin leaf and stem (SML and SMS) meth... Read More about Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity.

Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Almutairi, F. M., Aggour, A. M., & Carter, W. (2017). Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.011

Antidepressants are commonly employed for the treatment of major depressive disorders and other psychiatric conditions. We investigated the relatively acute cytotoxic effects of three commonly prescribed antidepressants: fluoxetine, sertraline, and c... Read More about Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations.

Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea (2017)
Journal Article
Nwidu, L. L., Elmorsy, E., Thornton, J., Wijamunige, B., Wijesekara, A., Tarbox, R., …Carter, W. (2017). Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea. Pharmaceutical Biology, 55(1), https://doi.org/10.1080/13880209.2017.1339283

Context: There is an unmet need to discover new treatments for Alzheimer’s disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae)... Read More about Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea.

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics (2016)
Journal Article
Elmorsy, E., Attalla, S., Fikry, E., Kocon, A., Turner, R., Christie, D., …Carter, W. (in press). Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics. Human and Experimental Toxicology, https://doi.org/10.1177/0960327116660751

Tuberculosis (TB) is an intractable chronic infection. Disease treatment with anti-TB drugs remains challenging due to drug-induced hepatotoxicity. The toxicity of the anti-TB drugs rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) either alon... Read More about Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics.

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury (2016)
Journal Article
Osna, N., Carter, W., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., …Kharbanda, K. (2016). Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), 6192-6200. https://doi.org/10.3748/wjg.v22.i27.6192

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cel... Read More about Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury (2016)
Journal Article
Carter, W., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., …Kharbanda, K. (2016). Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochemical and Biophysical Research Communications, 458(3), https://doi.org/10.1016/j.bbrc.2015.01.158

We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein damage. To furt... Read More about Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.

Alcohol-related brain damage in humans (2014)
Journal Article
Quintas, L. E. M., Erdozain, A. M., Morentin, B., Bedford, L., King, E., Tooth, D., …Carter, W. G. (2014). Alcohol-related brain damage in humans. PLoS ONE, 9(4), Article e93586. https://doi.org/10.1371/journal.pone.0093586

Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann’s area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining a... Read More about Alcohol-related brain damage in humans.

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article
Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. (2013). Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms. PLoS ONE, 8(4), Article e61442. https://doi.org/10.1371/journal.pone.0061442

Abnormal ?-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and ?-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More about Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms.

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides (2008)
Journal Article
Tarhoni, M. H., Lister, T., Ray, D. E., & Carter, W. G. (2008). Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers, 13(4), https://doi.org/10.1080/13547500801973563

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. Rat or human plasma... Read More about Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.