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Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia (2016)
Journal Article
Gaskin, P. L., Toledo-Rodriguez, M., Alexander, S. P., & Fone, K. C. (in press). Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. International Journal of Neuropsychopharmacology, https://doi.org/10.1093/ijnp/pyw062

Background: Dysfunction of dopaminergic, GABAergic and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP) and post-weaning soci... Read More about Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands (2015)
Journal Article
Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P., …Davies, J. A. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44(D1), D1054-D1068. https://doi.org/10.1093/nar/gkv1037

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Bas... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.

Concentrating tripartite quantum information (2015)
Journal Article
Streltsov, A., Lee, S., & Adesso, G. (2015). Concentrating tripartite quantum information. Physical Review Letters, 115, Article 030505. https://doi.org/10.1103/PhysRevLett.115.030505

We introduce the concentrated information of tripartite quantum states. For three parties Alice, Bob, and Charlie, it is defined as the maximal mutual information achievable between Alice and Charlie via local operations and classical communication p... Read More about Concentrating tripartite quantum information.

Homotopy colimits and global observables in Abelian gauge theory (2015)
Journal Article
Benini, M., Schenkel, A., & Szabo, R. J. (2015). Homotopy colimits and global observables in Abelian gauge theory. Letters in Mathematical Physics, 105(9), https://doi.org/10.1007/s11005-015-0765-y

We study chain complexes of field configurations and observables for Abelian gauge theory on contractible manifolds, and show that they can be extended to non-contractible manifolds by using techniques from homotopy theory. The extension prescription... Read More about Homotopy colimits and global observables in Abelian gauge theory.

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells (2015)
Journal Article
Jean-Gilles, L., Braitch, M., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., …Constantinescu, C. S. (2015). Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta Physiologica, 214(1), 63-74. https://doi.org/10.1111/apha.12474

© 2015 The Authors. Aims: To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro-inflammatory cytokines and its potential relevance to the inflammatory neurological disease, multiple sclerosis (MS). CB1 and CB2 sign... Read More about Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

A potential role for cannabinoid receptors in the therapeutic action of fenofibrate (2014)
Journal Article
Priestley, R. S., Nickolls, S. A., Alexander, S. P. H., & Kendall, D. A. (2015). A potential role for cannabinoid receptors in the therapeutic action of fenofibrate. FASEB Journal, 29(4), 1446-1455. https://doi.org/10.1096/fj.14-263053

Cannabinoids are reported to have actions through peroxisome proliferator-activated receptors (PPARs), which led us to investigate PPAR agonists for activity at the cannabinoid receptors. Radio-ligand binding and functional assays were conducted usin... Read More about A potential role for cannabinoid receptors in the therapeutic action of fenofibrate.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article
Alefishat, E., Alexander, S. P., & Ralevic, V. (2015). Effects of NAD at purine receptors in isolated blood vessels. Purinergic Signalling, 11(1), https://doi.org/10.1007/s11302-014-9428-1

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (2014)
Journal Article
Cable, J. C., Tan, G. D., Alexander, S. P., & O'Sullivan, S. E. (2014). The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. Lipids in Health and Disease, 13(1), Article 43. https://doi.org/10.1186/1476-511X-13-43

Background: Circulating endocannabinoid levels are increased in obesity and diabetes. We have shown that fatty acid amide hydrolase (FAAH, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with BMI in healthy... Read More about The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes.

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat (2014)
Journal Article
Gaskin, P. L., Fone, K., & Alexander, S. (2014). Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology, 231(12), 2533-2545. https://doi.org/10.1007/s00213-013-3424-y

Rationale: Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improve... Read More about Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands (2013)
Journal Article
Pawson, A. J., Sharman, J. L., Benson, H. E., Faccenda, E., Alexander, S. P., Buneman, O. P., …Harmar, A. J. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Research, 42(D1), Article D1098-D1106. https://doi.org/10.1093/nar/gkt1143

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands.

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition (2013)
Journal Article
Zachariou, M., Alexander, S. P., Coombes, S., & Christodoulou, C. (2013). A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition. PLoS ONE, 8(3), Article e58296. https://doi.org/10.1371/journal.pone.0058926

Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of lea... Read More about A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204

In this article, we highlight an issue that arises when using multiple b?values in a model?based analysis of diffusion MR data for tractography. The non?monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

Fundamental properties of Ca²⁺ signals (2011)
Journal Article
Thurley, K., Skupin, A., Thul, R., & Falcke, M. (2011). Fundamental properties of Ca²⁺ signals. BBA - General Subjects, 1820(8), https://doi.org/10.1016/j.bbagen.2011.10.007

Background Ca²⁺ is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca²⁺ concentration. Recent investigations changed basic ideas on the dynamic character of Ca²⁺ signals and challenge tradition... Read More about Fundamental properties of Ca²⁺ signals.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S., Norris, L. M., Pearson, R. G., …Chapman, V. (2010). Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis and Rheumatism, 62(12), https://doi.org/10.1002/art.27698

Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.

Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo (2006)
Journal Article
Harper, L. K., Beckett, S. R., Marsden, C. A., McCreary, A. C., & Alexander, S. P. (2006). Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo. Pharmacology Biochemistry and Behavior, 83(1), 114-121. https://doi.org/10.1016/j.pbb.2005.12.014

In this study, we have used the selective A2A adenosine receptor antagonist KW6002 to investigate the function of A2A receptors in the Lister hooded rat nucleus accumbens in vitro and in vivo. Radioligand binding studies confirmed a greater than 50-f... Read More about Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.

A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening (2005)
Journal Article
De Bank, P. A., Kendall, D. A., & Alexander, S. P. (2005). A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. Biochemical Pharmacology, 69(8), 1187-1193. https://doi.org/10.1016/j.bcp.2005.01.012

Signalling via the endocannabinoids anandamide and 2-arachidonylglycerol appears to be terminated largely through the action of the enzyme fatty acid amide hydrolase (FAAH). In this report, we describe a simple spectrophotometric assay to detect FAAH... Read More about A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening.

The cellular localization of adenosine receptors in rat neostriatum (1989)
Journal Article
Alexander, S. P., & Reddington, M. (1989). The cellular localization of adenosine receptors in rat neostriatum. Neuroscience, 28(3), 645-651. https://doi.org/10.1016/0306-4522%2889%2990011-0

Using quantitative autoradiography of ligand binding sites combined with lesions of specific neuronal pathways, the cellular locations of A1 and A2 adenosine receptors, as well as a third binding site for the adenosine receptor ligand, [3H]N-ethylcar... Read More about The cellular localization of adenosine receptors in rat neostriatum.

Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography (1982)
Journal Article
Gill, R., Alexander, S. P., & Moffat, A. C. (1982). Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 247(1), 39-45. https://doi.org/10.1016/S0021-9673%2800%2984854-2

Chromatographic retention and peak shapes for a group of five 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography have been examined with a series of eluents containing various amines as part of the buffer system. An ODS... Read More about Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography.