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Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis (2017)
Journal Article
Millar, S. A., Patel, H., Anderson, S. I., England, T. J., & O'Sullivan, S. (2017). Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis. Frontiers in Endocrinology, 8, Article 183. https://doi.org/10.3389/fendo.2017.00183

Background: Osteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far reaching extra-osseous effects... Read More about Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis.

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study (2017)
Journal Article
Jadoon, K. A., Tan, G. D., & O'Sullivan, S. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI insight, 2(11), Article e93760. https://doi.org/10.1172/jci.insight.93760

BACKGROUND. Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress.... Read More about A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.

In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats (2017)
Journal Article
Wheal, A. J., Jadoon, K., Randall, M. D., & O'Sullivan, S. (2017). In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats. Frontiers in Pharmacology, 8, Article 248. https://doi.org/10.3389/fphar.2017.00248

Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present... Read More about In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats.

The role of CB1 in intestinal permeability and inflammation (2017)
Journal Article
Karwad, M. A., Couch, D. G., Theophilidou, E., Sarmad, S., Barrett, D. A., Larvin, M., …O'Sullivan, S. (2017). The role of CB1 in intestinal permeability and inflammation. FASEB Journal, 31(8), 3267-3277. https://doi.org/10.1096/fj.201601346R

The endocannabinoid system has previously been shown to play a role in the permeability and inflammatory response of the human gut. The goal of our study was to determine the effects of endogenous anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) o... Read More about The role of CB1 in intestinal permeability and inflammation.

Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015) (2017)
Journal Article
England, T. J., Hedstrom, A., O'Sullivan, S., Donnelly, R., Barrett, D. A., Sarmad, S., …Bath, P. M. (2017). Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015). Stroke, 48(5), https://doi.org/10.1161/STROKEAHA.116.016429

Background: Repeated episodes of limb ischaemia and reperfusion (remote ischaemic conditioning, RIC) may improve outcome after acute stroke. Methods: We performed a pilot blinded placebo-controlled trial in patients with acute ischaemic stroke, ra... Read More about Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015).

A systematic review and meta-analysis of the haemodynamic effects of cannabidiol (2017)
Journal Article
Sultan, S. R., Millar, S. A., England, T. J., & O'Sullivan, S. (2017). A systematic review and meta-analysis of the haemodynamic effects of cannabidiol. Frontiers in Pharmacology, 8, Article 81. https://doi.org/10.3389/fphar.2017.00081

Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread. The aim of this systematic review was to establish... Read More about A systematic review and meta-analysis of the haemodynamic effects of cannabidiol.

Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPAR? (2016)
Journal Article
Karwad, M. A., Macpherson, T., Wang, B., Theophilidou, E., Sarmad, S., Barrett, D. A., …O'Sullivan, S. (2017). Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα. FASEB Journal, 31(2), 469-481. https://doi.org/10.1096/fj.201500132

Cannabinoids modulate intestinal permeability through cannabinoid receptor 1 (CB1). The endocannabinoid-like compounds oleoylethanolamine (OEA) and palmitoylethanolamine (PEA) play an important role in digestive regulation, and we hypothesized they w... Read More about Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPAR?.

The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries (2016)
Journal Article
Stanley, C. P., Hind, W. H., Tufarelli, C., & O'Sullivan, S. (2016). The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries. Pharmacological Research, 113(A), 356-363. https://doi.org/10.1016/j.phrs.2016.08.028

The endocannabinoid anandamide (AEA) causes vasorelaxation in animal studies. Although circulating AEA levels are increased in many pathologies, little is known about its vascular effects in humans. The aim of this work was to characterise the effect... Read More about The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries.

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study (2016)
Journal Article
Jadoon, K. A., Ratcliffe, S. H., Barrett, D. A., Thomas, E. L., Stott, C., Bell, J. D., …Tan, G. D. (2016). Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care, 39(10), 1777-1786. https://doi.org/10.2337/dc16-0650

OBJECTIVE Cannabidiol (CBD) and Δ9-tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids affecting lipid and glucose metabolism in animal models. This study set out to examine the effects of these compounds in patients with type 2 diabe... Read More about Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., …Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite (2016)
Journal Article
Shang, V., O'Sullivan, S., Kendall, D., & Roberts, R. E. (2016). The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacological Research, 105, https://doi.org/10.1016/j.phrs.2016.01.023

Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the lossof barrier function and an elevated sensitivity to environmental insults. An increased release of theendogenous cannabinoid, anandamide in response... Read More about The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.

Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygen-glucose deprivation via PPAR? and 5-HT1A (2015)
Journal Article
Hind, W. H., England, T. J., & O'Sullivan, S. E. (2016). Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygen-glucose deprivation via PPAR? and 5-HT1A. British Journal of Pharmacology, 173(5), 815-825. doi:10.1111/bph.13368

Background and Purpose: In vivo and in vitro studies have demonstrated a protective effect of cannabidiol (CBD) in reducing infarct size in stroke models and against epithelial barrier damage in numerous disease models. We aimed to investigate whethe... Read More about Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygen-glucose deprivation via PPAR? and 5-HT1A.

Endocannabinoids modulate human blood-brain barrier permeability in vitro (2015)
Journal Article
Hind, W. H., Tufarelli, C., Neophytou, M., Anderson, S. I., England, T. J., & O'Sullivan, S. (2015). Endocannabinoids modulate human blood-brain barrier permeability in vitro. British Journal of Pharmacology, 172(12), 3015-3027. https://doi.org/10.1111/bph.13106

Background and Purpose Endocannabinoids alter permeability at various epithelial barriers, and cannabinoid receptors and endocannabinoid levels are elevated by stroke, with potential neuroprotective effects. We therefore explored the role of endoc... Read More about Endocannabinoids modulate human blood-brain barrier permeability in vitro.

Cannabinoids in experimental stroke: a systematic review and meta-analysis (2014)
Journal Article
England, T. J., Hind, W. H., Rasid, N. A., & O'Sullivan, S. (2015). Cannabinoids in experimental stroke: a systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.218

Cannabinoids (CBs) show promise as neuroprotectants with some agents already licensed in humans for other conditions. We systematically reviewed CBs in preclinical stroke to guide further experimental protocols. We selected controlled studies assessi... Read More about Cannabinoids in experimental stroke: a systematic review and meta-analysis.

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism? (2014)
Journal Article
Gardner, D. S., Welham, S. J., Dunford, L. J., McCulloch, T. A., Hodi, Z., Sleeman, P., …Devonald, M. A. (2014). Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?. AJP - Renal Physiology, 306(8), F873-F884. https://doi.org/10.1152/ajprenal.00576.2013

Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renop... Read More about Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?.